Linking neuronal lineage and wiring specificity
Abstract Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching between pre- and post-synaptic partners. How neuronal lineage and birth timing inf...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-04-01
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| Series: | Neural Development |
| Online Access: | http://link.springer.com/article/10.1186/s13064-018-0102-0 |
| _version_ | 1811215791899541504 |
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| author | Hongjie Li S. Andrew Shuster Jiefu Li Liqun Luo |
| author_facet | Hongjie Li S. Andrew Shuster Jiefu Li Liqun Luo |
| author_sort | Hongjie Li |
| collection | DOAJ |
| description | Abstract Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching between pre- and post-synaptic partners. How neuronal lineage and birth timing influence wiring specificity remains an open question. Recent findings suggest that the relationships between lineage, birth timing, and wiring specificity vary in different neuronal circuits. In this review, we summarize our current understanding of the cellular, molecular, and developmental mechanisms linking neuronal lineage and birth timing to wiring specificity in a few specific systems in Drosophila and mice, and review different methods employed to explore these mechanisms. |
| first_indexed | 2024-04-12T06:28:27Z |
| format | Article |
| id | doaj.art-afc0b9e75c5d40728d5c041a88d06deb |
| institution | Directory Open Access Journal |
| issn | 1749-8104 |
| language | English |
| last_indexed | 2024-04-12T06:28:27Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Neural Development |
| spelling | doaj.art-afc0b9e75c5d40728d5c041a88d06deb2022-12-22T03:44:05ZengBMCNeural Development1749-81042018-04-0113111910.1186/s13064-018-0102-0Linking neuronal lineage and wiring specificityHongjie Li0S. Andrew Shuster1Jiefu Li2Liqun Luo3Department of Biology and Howard Hughes Medical Institute, Stanford UniversityDepartment of Biology and Howard Hughes Medical Institute, Stanford UniversityDepartment of Biology and Howard Hughes Medical Institute, Stanford UniversityDepartment of Biology and Howard Hughes Medical Institute, Stanford UniversityAbstract Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching between pre- and post-synaptic partners. How neuronal lineage and birth timing influence wiring specificity remains an open question. Recent findings suggest that the relationships between lineage, birth timing, and wiring specificity vary in different neuronal circuits. In this review, we summarize our current understanding of the cellular, molecular, and developmental mechanisms linking neuronal lineage and birth timing to wiring specificity in a few specific systems in Drosophila and mice, and review different methods employed to explore these mechanisms.http://link.springer.com/article/10.1186/s13064-018-0102-0 |
| spellingShingle | Hongjie Li S. Andrew Shuster Jiefu Li Liqun Luo Linking neuronal lineage and wiring specificity Neural Development |
| title | Linking neuronal lineage and wiring specificity |
| title_full | Linking neuronal lineage and wiring specificity |
| title_fullStr | Linking neuronal lineage and wiring specificity |
| title_full_unstemmed | Linking neuronal lineage and wiring specificity |
| title_short | Linking neuronal lineage and wiring specificity |
| title_sort | linking neuronal lineage and wiring specificity |
| url | http://link.springer.com/article/10.1186/s13064-018-0102-0 |
| work_keys_str_mv | AT hongjieli linkingneuronallineageandwiringspecificity AT sandrewshuster linkingneuronallineageandwiringspecificity AT jiefuli linkingneuronallineageandwiringspecificity AT liqunluo linkingneuronallineageandwiringspecificity |