A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants
Abstract Background The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaire...
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12916-018-1062-2 |
| _version_ | 1818591592953413632 |
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| author | Po-Wen Ku Andrew Steptoe Yung Liao Ming-Chun Hsueh Li-Jung Chen |
| author_facet | Po-Wen Ku Andrew Steptoe Yung Liao Ming-Chun Hsueh Li-Jung Chen |
| author_sort | Po-Wen Ku |
| collection | DOAJ |
| description | Abstract Background The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaired in adults aged 18–64 years old. We also examined whether there are differences between studies using self-report ST and those with device-based ST. Methods Prospective cohort studies providing effect estimates of daily ST (exposure) on all-cause mortality (outcome) were identified via MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar databases until January 2018. Dose-response relationships between daily ST and all-cause mortality were examined using random-effects meta-regression models. Results Based on the pooled data for more than 1 million participants from 19 studies, the results showed a log-linear dose-response association between daily ST and all-cause mortality. Overall, more time spent in sedentary behaviors is associated with increased mortality risks. However, the method of measuring ST moderated the association between daily ST and mortality risk (p < 0.05). The cut-off of daily ST in studies with self-report ST was 7 h/day in comparison with 9 h/day for those with device-based ST. Conclusions Higher amounts of daily ST are log-linearly associated with increased risk of all-cause mortality in adults. On the basis of a limited number of studies using device-based measures, the findings suggest that it may be appropriate to encourage adults to engage in less sedentary behaviors, with fewer than 9 h a day being relevant for all-cause mortality. |
| first_indexed | 2024-12-16T10:14:54Z |
| format | Article |
| id | doaj.art-afc1b9ffb22f46edba42cd122dc2d356 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-16T10:14:54Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-afc1b9ffb22f46edba42cd122dc2d3562022-12-21T22:35:28ZengBMCBMC Medicine1741-70152018-05-011611910.1186/s12916-018-1062-2A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participantsPo-Wen Ku0Andrew Steptoe1Yung Liao2Ming-Chun Hsueh3Li-Jung Chen4Graduate Institute of Sports and Health, National Changhua University of EducationDepartment of Behavioural Science and Health, University College LondonDepartment of Health Promotion and Health Education, National Taiwan Normal UniversityDepartment of Physical Education, National Taiwan Normal UniversityDepartment of Exercise Health Science, National Taiwan University of SportAbstract Background The appropriate limit to the amount of daily sedentary time (ST) required to minimize mortality is uncertain. This meta-analysis aimed to quantify the dose-response association between daily ST and all-cause mortality and to explore the cut-off point above which health is impaired in adults aged 18–64 years old. We also examined whether there are differences between studies using self-report ST and those with device-based ST. Methods Prospective cohort studies providing effect estimates of daily ST (exposure) on all-cause mortality (outcome) were identified via MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar databases until January 2018. Dose-response relationships between daily ST and all-cause mortality were examined using random-effects meta-regression models. Results Based on the pooled data for more than 1 million participants from 19 studies, the results showed a log-linear dose-response association between daily ST and all-cause mortality. Overall, more time spent in sedentary behaviors is associated with increased mortality risks. However, the method of measuring ST moderated the association between daily ST and mortality risk (p < 0.05). The cut-off of daily ST in studies with self-report ST was 7 h/day in comparison with 9 h/day for those with device-based ST. Conclusions Higher amounts of daily ST are log-linearly associated with increased risk of all-cause mortality in adults. On the basis of a limited number of studies using device-based measures, the findings suggest that it may be appropriate to encourage adults to engage in less sedentary behaviors, with fewer than 9 h a day being relevant for all-cause mortality.http://link.springer.com/article/10.1186/s12916-018-1062-2Sedentary behaviorSittingInactivityReviewCut-pointRecommendation |
| spellingShingle | Po-Wen Ku Andrew Steptoe Yung Liao Ming-Chun Hsueh Li-Jung Chen A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants BMC Medicine Sedentary behavior Sitting Inactivity Review Cut-point Recommendation |
| title | A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants |
| title_full | A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants |
| title_fullStr | A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants |
| title_full_unstemmed | A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants |
| title_short | A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants |
| title_sort | cut off of daily sedentary time and all cause mortality in adults a meta regression analysis involving more than 1 million participants |
| topic | Sedentary behavior Sitting Inactivity Review Cut-point Recommendation |
| url | http://link.springer.com/article/10.1186/s12916-018-1062-2 |
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