Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis
Statement of the Problem: Periodontal diseases are complex oral diseases characterized by bacterial-induced inflammatory destruction of tooth-supporting tissues. Porphyromonas gingivalis (P. gingivalis) is a common gram-negative anaerobic oral bacteria strongly associated with periodontal disease....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2018-09-01
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| Series: | Journal of Dentistry |
| Subjects: | |
| Online Access: | http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1779/1136 |
| _version_ | 1818358974417731584 |
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| author | Mohammad Rafiei Faezeh Kiani Kourosh Sayehmiri Fatemeh Sayehmiri Mostafa Tavirani Majid Dousti Abdolkarim Sheikhi |
| author_facet | Mohammad Rafiei Faezeh Kiani Kourosh Sayehmiri Fatemeh Sayehmiri Mostafa Tavirani Majid Dousti Abdolkarim Sheikhi |
| author_sort | Mohammad Rafiei |
| collection | DOAJ |
| description | Statement of the Problem: Periodontal diseases are complex oral diseases characterized by bacterial-induced inflammatory destruction of tooth-supporting tissues. Porphyromonas gingivalis (P. gingivalis) is a common gram-negative anaerobic oral bacteria strongly associated with periodontal disease.
Purpose: The present study was conducted to estimate prevalence of P. gingivalis in patients with periodontal diseases by using meta-analysis method.
Martials and Method: Different databases including PubMed, EmBase, Scopus, the Institute for Scientific Information (ISI) Web of Science, and the Cochrane Library were searched to identify original English-language studies addressing prevalence of P. gingivalis in periodontal diseases up to December 2014. The random effects model was applied in the meta-analysis and the heterogeneity between studies was assessed using a Cochran test and the I2 index. Funnel plots and Egger test were used to examine publication bias. Statistical analyses were performed using STATA version 12.
Results: Forty-two eligible studies published during 1993- 2016 were selected for meta-analysis. Considering all the included studies, the total sample size was 5,884 individuals containing 2,576 healthy people with a mean age of 37.21±7.45 years and 3,308 periodontal patients with a mean age of 44.16±8.35 years. Overall, the prevalence of P. gingivalis was 78% [95% CI: 74-81] in periodontal diseases group and 34% [95% CI: 26-41] in healthy individuals. There was a significantly higher prevalence of P.gingivalis in individuals with periodontal diseases compared to healthy subjects [78% versus 34%, respectively].
Conclusion: This study indicates that P. gingivalis is highly present in subjects with periodontal diseases and it also appears in periodontally healthy people, although to a lesser extent. Thus, the presence of P. gingivalis increases the chance of periodontal disease and it can be considered as a main potential risk factor. |
| first_indexed | 2024-12-13T20:37:31Z |
| format | Article |
| id | doaj.art-afc2341eb1bb4cac9e0e5ae374310f5b |
| institution | Directory Open Access Journal |
| issn | 2345-6485 2345-6418 |
| language | English |
| last_indexed | 2024-12-13T20:37:31Z |
| publishDate | 2018-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Dentistry |
| spelling | doaj.art-afc2341eb1bb4cac9e0e5ae374310f5b2022-12-21T23:32:15ZengShiraz University of Medical SciencesJournal of Dentistry2345-64852345-64182018-09-01193232242Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysisMohammad Rafiei 0Faezeh Kiani 1Kourosh Sayehmiri 2Fatemeh Sayehmiri 3Mostafa Tavirani 4Majid Dousti 5Abdolkarim Sheikhi 6Dept. of Biostatistics and Epidemiology, Arak University of Medical Sciences, Arak, Iran.Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.Dept. of Social Medicine, Dept. of Biostatistics, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranProteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDept. of Parasitology, School of Medicine, Shiraz University of Medical Sciences, Fars, Iran. Dept. of Immunology, School of Medicine, Dezful University of Medical Sciences, Dezful, Khuzestan, Iran. Statement of the Problem: Periodontal diseases are complex oral diseases characterized by bacterial-induced inflammatory destruction of tooth-supporting tissues. Porphyromonas gingivalis (P. gingivalis) is a common gram-negative anaerobic oral bacteria strongly associated with periodontal disease. Purpose: The present study was conducted to estimate prevalence of P. gingivalis in patients with periodontal diseases by using meta-analysis method. Martials and Method: Different databases including PubMed, EmBase, Scopus, the Institute for Scientific Information (ISI) Web of Science, and the Cochrane Library were searched to identify original English-language studies addressing prevalence of P. gingivalis in periodontal diseases up to December 2014. The random effects model was applied in the meta-analysis and the heterogeneity between studies was assessed using a Cochran test and the I2 index. Funnel plots and Egger test were used to examine publication bias. Statistical analyses were performed using STATA version 12. Results: Forty-two eligible studies published during 1993- 2016 were selected for meta-analysis. Considering all the included studies, the total sample size was 5,884 individuals containing 2,576 healthy people with a mean age of 37.21±7.45 years and 3,308 periodontal patients with a mean age of 44.16±8.35 years. Overall, the prevalence of P. gingivalis was 78% [95% CI: 74-81] in periodontal diseases group and 34% [95% CI: 26-41] in healthy individuals. There was a significantly higher prevalence of P.gingivalis in individuals with periodontal diseases compared to healthy subjects [78% versus 34%, respectively]. Conclusion: This study indicates that P. gingivalis is highly present in subjects with periodontal diseases and it also appears in periodontally healthy people, although to a lesser extent. Thus, the presence of P. gingivalis increases the chance of periodontal disease and it can be considered as a main potential risk factor.http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1779/1136Porphyromonas gingivalis ● Periodontal diseases ● Chronic periodontitis ● Aggressive periodontitis ● Gingivitis |
| spellingShingle | Mohammad Rafiei Faezeh Kiani Kourosh Sayehmiri Fatemeh Sayehmiri Mostafa Tavirani Majid Dousti Abdolkarim Sheikhi Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis Journal of Dentistry Porphyromonas gingivalis ● Periodontal diseases ● Chronic periodontitis ● Aggressive periodontitis ● Gingivitis |
| title | Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis |
| title_full | Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis |
| title_fullStr | Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis |
| title_full_unstemmed | Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis |
| title_short | Prevalence of Anaerobic Bacteria (P.gingivalis) as Major Microbial Agent in the Incidence Periodontal Diseases by Meta-analysis |
| title_sort | prevalence of anaerobic bacteria p gingivalis as major microbial agent in the incidence periodontal diseases by meta analysis |
| topic | Porphyromonas gingivalis ● Periodontal diseases ● Chronic periodontitis ● Aggressive periodontitis ● Gingivitis |
| url | http://dentjods.sums.ac.ir/index.php/JDSUMS/article/view/1779/1136 |
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