Insights into Gradient and Anisotropic Pore Structures of Capiox<sup>®</sup> Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 Permeability
When using the extracorporeal capillary membrane oxygenator (sample A) for ECMO treatments of COVID-19 severely ill patients, which is dominantly used in Japan and worldwide, there is a concern about the risk of SARS-CoV-2 scattering from the gas outlet port of the membrane oxygenator. Terumo has la...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/12/3/314 |
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| author | Makoto Fukuda Ryo Tanaka Kazunori Sadano Asako Tokumine Tomohiro Mori Hitoshi Saomoto Kiyotaka Sakai |
| author_facet | Makoto Fukuda Ryo Tanaka Kazunori Sadano Asako Tokumine Tomohiro Mori Hitoshi Saomoto Kiyotaka Sakai |
| author_sort | Makoto Fukuda |
| collection | DOAJ |
| description | When using the extracorporeal capillary membrane oxygenator (sample A) for ECMO treatments of COVID-19 severely ill patients, which is dominantly used in Japan and worldwide, there is a concern about the risk of SARS-CoV-2 scattering from the gas outlet port of the membrane oxygenator. Terumo has launched two types of membranes (sample A and sample B), both of which are produced by the microphase separation processes using polymethylpentene (PMP) and polypropylene (PP), respectively. However, the pore structures of these membranes and the SARS-CoV-2 permeability through the membrane wall have not been clarified. In this study, we analyzed the pore structures of these gas exchange membranes using our previous approach and verified the SARS-CoV-2 permeation through the membrane wall. Both have the unique gradient and anisotropic pore structure which gradually become denser from the inside to the outside of the membrane wall, and the inner and outer surfaces of the membrane have completely different pore structures. The pore structure of sample A is also completely different from the other membrane made by the melt-extruded stretch process. From this, the pore structure of the ECMO membrane is controlled by designing various membrane-forming processes using the appropriate materials. In sample A, water vapor permeates through the coating layer on the outer surface, but no pores that allow SARS-CoV-2 to penetrate are observed. Therefore, it is unlikely that SARS-CoV-2 permeates through the membrane wall and scatter from sample A, raising the possibility of secondary ECMO infection. These results provide new insights into the evolution of a next-generation ECMO membrane. |
| first_indexed | 2024-03-09T13:22:40Z |
| format | Article |
| id | doaj.art-afc35558811d4ec9b66688ecbeb50dda |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T13:22:40Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-afc35558811d4ec9b66688ecbeb50dda2023-11-30T21:28:43ZengMDPI AGMembranes2077-03752022-03-0112331410.3390/membranes12030314Insights into Gradient and Anisotropic Pore Structures of Capiox<sup>®</sup> Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 PermeabilityMakoto Fukuda0Ryo Tanaka1Kazunori Sadano2Asako Tokumine3Tomohiro Mori4Hitoshi Saomoto5Kiyotaka Sakai6Department of Biomedical Engineering, Kindai University, 930 Nishimitani, Kinokawa-City 649-6493, JapanDepartment of Biomedical Engineering, Kindai University, 930 Nishimitani, Kinokawa-City 649-6493, JapanDepartment of Biomedical Engineering, Kindai University, 930 Nishimitani, Kinokawa-City 649-6493, JapanDepartment of Biomedical Engineering, Kindai University, 930 Nishimitani, Kinokawa-City 649-6493, JapanIndustrial Technology Center of Wakayama Prefecture, 60 Ogura, Wakayama-City 649-6261, JapanIndustrial Technology Center of Wakayama Prefecture, 60 Ogura, Wakayama-City 649-6261, JapanDepartment of Applied Chemistry, School of Advance Science and Engineering, Waseda University, 3-4-1 Okubo, Tokyo 169-8555, JapanWhen using the extracorporeal capillary membrane oxygenator (sample A) for ECMO treatments of COVID-19 severely ill patients, which is dominantly used in Japan and worldwide, there is a concern about the risk of SARS-CoV-2 scattering from the gas outlet port of the membrane oxygenator. Terumo has launched two types of membranes (sample A and sample B), both of which are produced by the microphase separation processes using polymethylpentene (PMP) and polypropylene (PP), respectively. However, the pore structures of these membranes and the SARS-CoV-2 permeability through the membrane wall have not been clarified. In this study, we analyzed the pore structures of these gas exchange membranes using our previous approach and verified the SARS-CoV-2 permeation through the membrane wall. Both have the unique gradient and anisotropic pore structure which gradually become denser from the inside to the outside of the membrane wall, and the inner and outer surfaces of the membrane have completely different pore structures. The pore structure of sample A is also completely different from the other membrane made by the melt-extruded stretch process. From this, the pore structure of the ECMO membrane is controlled by designing various membrane-forming processes using the appropriate materials. In sample A, water vapor permeates through the coating layer on the outer surface, but no pores that allow SARS-CoV-2 to penetrate are observed. Therefore, it is unlikely that SARS-CoV-2 permeates through the membrane wall and scatter from sample A, raising the possibility of secondary ECMO infection. These results provide new insights into the evolution of a next-generation ECMO membrane.https://www.mdpi.com/2077-0375/12/3/314extracorporeal membrane oxygenator (ECMO)polymethylpentene (PMP)polypropylene (PP)SARS-CoV-2water vapor permeation |
| spellingShingle | Makoto Fukuda Ryo Tanaka Kazunori Sadano Asako Tokumine Tomohiro Mori Hitoshi Saomoto Kiyotaka Sakai Insights into Gradient and Anisotropic Pore Structures of Capiox<sup>®</sup> Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 Permeability Membranes extracorporeal membrane oxygenator (ECMO) polymethylpentene (PMP) polypropylene (PP) SARS-CoV-2 water vapor permeation |
| title | Insights into Gradient and Anisotropic Pore Structures of Capiox<sup>®</sup> Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 Permeability |
| title_full | Insights into Gradient and Anisotropic Pore Structures of Capiox<sup>®</sup> Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 Permeability |
| title_fullStr | Insights into Gradient and Anisotropic Pore Structures of Capiox<sup>®</sup> Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 Permeability |
| title_full_unstemmed | Insights into Gradient and Anisotropic Pore Structures of Capiox<sup>®</sup> Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 Permeability |
| title_short | Insights into Gradient and Anisotropic Pore Structures of Capiox<sup>®</sup> Gas Exchange Membranes for ECMO: Theoretically Verifying SARS-CoV-2 Permeability |
| title_sort | insights into gradient and anisotropic pore structures of capiox sup r sup gas exchange membranes for ecmo theoretically verifying sars cov 2 permeability |
| topic | extracorporeal membrane oxygenator (ECMO) polymethylpentene (PMP) polypropylene (PP) SARS-CoV-2 water vapor permeation |
| url | https://www.mdpi.com/2077-0375/12/3/314 |
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