Proteomic Profiling of Burkholderia thailandensis During Host Infection Using Bio-Orthogonal Noncanonical Amino Acid Tagging (BONCAT)

Proteomic Profiling of Burkholderia thailandensis During Host Infection Using Bio-Orthogonal Noncanonical Amino Acid Tagging (BONCAT)

Burkholderia pseudomallei and B. mallei are the causative agents of melioidosis and glanders, respectively, and are often fatal to humans and animals. Owing to the high fatality rate, potential for spread by aerosolization, and the lack of efficacious therapeutics, B. pseudomallei and B. mallei are...

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Bibliographic Details
Main Authors: Magdalena Franco, Patrik M. D'haeseleer, Steven S. Branda, Megan J. Liou, Yasmeen Haider, Brent W. Segelke, Sahar H. El-Etr
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Burkholderia
BONCAT
orthogonal amino acid labeling
intracellular pathogen
host infection
protein enrichment
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00370/full

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