Efficacy and Systemic Safety of Epidermal Growth Factor plus Silver Sulfadiazine Cream for the Treatment of Partial Thickness Burn Wounds
Objective: This clinical study was undertaken to investigate the efficacy and safety of topical Epidermal Growth Factor (EGF) plus silver sulfadiazine cream for the treatment of partial thickness burn wounds. Material and Methods: This investigation was a prospective clinical study in patients with...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2012-08-01
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| Series: | Journal of Health Science and Medical Research (JHSMR) |
| Subjects: | |
| Online Access: | https://www.jhsmr.org/index.php/jhsmr/article/view/291 |
| _version_ | 1818927962924253184 |
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| author | Nantaporn Namviriyachote Pornprom Muangman Pornanong Aramwit |
| author_facet | Nantaporn Namviriyachote Pornprom Muangman Pornanong Aramwit |
| author_sort | Nantaporn Namviriyachote |
| collection | DOAJ |
| description | Objective: This clinical study was undertaken to investigate the efficacy and safety of topical Epidermal Growth Factor (EGF) plus silver sulfadiazine cream for the treatment of partial thickness burn wounds.
Material and Methods: This investigation was a prospective clinical study in patients with partial thickness burn wounds. Patients eligible for this study must have burn area higher than 20% of total body surface area and be aged between 18 and 60 years. Total of 9 patients was recruited into this study and all patients were treated with EGF plus silver sulfadiazine cream once daily for consecutively 4 weeks. Pain score was evaluated using a visual analog scale and blood serum was used to evaluate liver and kidney function on the day of enrollment and on the 7th, 14th, 21st and 28th day of treatment.
Results: Average pain score was the highest at the first time of treatment and then significantly declined after that. Liver and kidney functions were almost in normal range except aspartate aminotransferase (AST) and alanine transaminase (ALT), which were a little over the upper limit at initial of treatment then subsided to normal in the second week. There was no abnormality at the wound site throughout the study.
Conclusion: It is concluded that EGF plus silver sulfadiazine cream is safe for the treatment of partial thickness burn wounds. |
| first_indexed | 2024-12-20T03:21:21Z |
| format | Article |
| id | doaj.art-afc5c517cbac40b99d59cbd206ef5348 |
| institution | Directory Open Access Journal |
| issn | 2586-9981 2630-0559 |
| language | English |
| last_indexed | 2024-12-20T03:21:21Z |
| publishDate | 2012-08-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Journal of Health Science and Medical Research (JHSMR) |
| spelling | doaj.art-afc5c517cbac40b99d59cbd206ef53482022-12-21T19:55:12ZengPrince of Songkla UniversityJournal of Health Science and Medical Research (JHSMR)2586-99812630-05592012-08-01304209220305Efficacy and Systemic Safety of Epidermal Growth Factor plus Silver Sulfadiazine Cream for the Treatment of Partial Thickness Burn WoundsNantaporn Namviriyachote0Pornprom Muangman1Pornanong Aramwit2Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330,Trauma Division, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok 10700,Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330,Objective: This clinical study was undertaken to investigate the efficacy and safety of topical Epidermal Growth Factor (EGF) plus silver sulfadiazine cream for the treatment of partial thickness burn wounds. Material and Methods: This investigation was a prospective clinical study in patients with partial thickness burn wounds. Patients eligible for this study must have burn area higher than 20% of total body surface area and be aged between 18 and 60 years. Total of 9 patients was recruited into this study and all patients were treated with EGF plus silver sulfadiazine cream once daily for consecutively 4 weeks. Pain score was evaluated using a visual analog scale and blood serum was used to evaluate liver and kidney function on the day of enrollment and on the 7th, 14th, 21st and 28th day of treatment. Results: Average pain score was the highest at the first time of treatment and then significantly declined after that. Liver and kidney functions were almost in normal range except aspartate aminotransferase (AST) and alanine transaminase (ALT), which were a little over the upper limit at initial of treatment then subsided to normal in the second week. There was no abnormality at the wound site throughout the study. Conclusion: It is concluded that EGF plus silver sulfadiazine cream is safe for the treatment of partial thickness burn wounds.https://www.jhsmr.org/index.php/jhsmr/article/view/291burn woundepidermal growth factorsafetysilver sulfadiazine |
| spellingShingle | Nantaporn Namviriyachote Pornprom Muangman Pornanong Aramwit Efficacy and Systemic Safety of Epidermal Growth Factor plus Silver Sulfadiazine Cream for the Treatment of Partial Thickness Burn Wounds Journal of Health Science and Medical Research (JHSMR) burn wound epidermal growth factor safety silver sulfadiazine |
| title | Efficacy and Systemic Safety of Epidermal Growth Factor plus Silver Sulfadiazine Cream for the Treatment of Partial Thickness Burn Wounds |
| title_full | Efficacy and Systemic Safety of Epidermal Growth Factor plus Silver Sulfadiazine Cream for the Treatment of Partial Thickness Burn Wounds |
| title_fullStr | Efficacy and Systemic Safety of Epidermal Growth Factor plus Silver Sulfadiazine Cream for the Treatment of Partial Thickness Burn Wounds |
| title_full_unstemmed | Efficacy and Systemic Safety of Epidermal Growth Factor plus Silver Sulfadiazine Cream for the Treatment of Partial Thickness Burn Wounds |
| title_short | Efficacy and Systemic Safety of Epidermal Growth Factor plus Silver Sulfadiazine Cream for the Treatment of Partial Thickness Burn Wounds |
| title_sort | efficacy and systemic safety of epidermal growth factor plus silver sulfadiazine cream for the treatment of partial thickness burn wounds |
| topic | burn wound epidermal growth factor safety silver sulfadiazine |
| url | https://www.jhsmr.org/index.php/jhsmr/article/view/291 |
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