Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) Pignatti
<i>Vinca sardoa</i> (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblas...
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5639 |
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| author | Daniela De Vita Claudio Frezza Fabio Sciubba Chiara Toniolo Camilla Badiali Rita Petrucci Martina Bortolami Paola Di Matteo Daniele Rocco Annarita Stringaro Marisa Colone Andrea Maxia Maria Teresa Petrucci Mauro Serafini Sebastiano Foddai |
| author_facet | Daniela De Vita Claudio Frezza Fabio Sciubba Chiara Toniolo Camilla Badiali Rita Petrucci Martina Bortolami Paola Di Matteo Daniele Rocco Annarita Stringaro Marisa Colone Andrea Maxia Maria Teresa Petrucci Mauro Serafini Sebastiano Foddai |
| author_sort | Daniela De Vita |
| collection | DOAJ |
| description | <i>Vinca sardoa</i> (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of <i>V. sardoa</i> alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations. |
| first_indexed | 2024-03-11T00:22:44Z |
| format | Article |
| id | doaj.art-afc6519233754df6ae1e6125db96e102 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:22:44Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-afc6519233754df6ae1e6125db96e1022023-11-18T23:16:53ZengMDPI AGMolecules1420-30492023-07-012815563910.3390/molecules28155639Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) PignattiDaniela De Vita0Claudio Frezza1Fabio Sciubba2Chiara Toniolo3Camilla Badiali4Rita Petrucci5Martina Bortolami6Paola Di Matteo7Daniele Rocco8Annarita Stringaro9Marisa Colone10Andrea Maxia11Maria Teresa Petrucci12Mauro Serafini13Sebastiano Foddai14Department of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, ItalyDepartment of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, ItalyDepartment of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, ItalyDepartment of Basic and Applied Sciences for Engineering, “Sapienza” University of Rome, Via Castro Laurenziano 7, 00161 Rome, ItalyNational Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyNational Center for Drug Research and Evaluation, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, ItalyLaboratory of Economic and Pharmaceutical Botany, Department of Life and Environmental Sciences, University of Cagliari, Viale S. Ignazio da Laconi 13, 09123 Cagliari, ItalyDepartment of Cellular Biotechnologies and Hematology, “Sapienza” University of Rome, Via Benevento 6, 00161 Rome, ItalyDepartment of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, ItalyDepartment of Environmental Biology, “Sapienza” University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy<i>Vinca sardoa</i> (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of <i>V. sardoa</i> alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 µg/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.https://www.mdpi.com/1420-3049/28/15/5639<i>Vinca sardoa</i> (Stearn) Pignatti<i>Vinca difformis</i> subsp. <i>sardoa</i> StearnSardinian periwinklealkaloidsantileukemic activityESI-MS/MS characterization |
| spellingShingle | Daniela De Vita Claudio Frezza Fabio Sciubba Chiara Toniolo Camilla Badiali Rita Petrucci Martina Bortolami Paola Di Matteo Daniele Rocco Annarita Stringaro Marisa Colone Andrea Maxia Maria Teresa Petrucci Mauro Serafini Sebastiano Foddai Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) Pignatti Molecules <i>Vinca sardoa</i> (Stearn) Pignatti <i>Vinca difformis</i> subsp. <i>sardoa</i> Stearn Sardinian periwinkle alkaloids antileukemic activity ESI-MS/MS characterization |
| title | Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) Pignatti |
| title_full | Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) Pignatti |
| title_fullStr | Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) Pignatti |
| title_full_unstemmed | Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) Pignatti |
| title_short | Phytochemical Analysis and <i>In Vitro</i> Antileukemic Activity of Alkaloid-Enriched Extracts from <i>Vinca sardoa</i> (Stearn) Pignatti |
| title_sort | phytochemical analysis and i in vitro i antileukemic activity of alkaloid enriched extracts from i vinca sardoa i stearn pignatti |
| topic | <i>Vinca sardoa</i> (Stearn) Pignatti <i>Vinca difformis</i> subsp. <i>sardoa</i> Stearn Sardinian periwinkle alkaloids antileukemic activity ESI-MS/MS characterization |
| url | https://www.mdpi.com/1420-3049/28/15/5639 |
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