Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults
BackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese. Here, we aimed to examine the association between serum furin and fasting glucose in Chinese adults.MethodsSerum furin and fasting p...
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| Format: | Article |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.781890/full |
| _version_ | 1818732681205121024 |
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| author | Yan He Hanyun Zhu Min Zhang Jing Li Shengqi Ma Yin Lu Linan Chen Mingzhi Zhang Hao Peng Hao Peng |
| author_facet | Yan He Hanyun Zhu Min Zhang Jing Li Shengqi Ma Yin Lu Linan Chen Mingzhi Zhang Hao Peng Hao Peng |
| author_sort | Yan He |
| collection | DOAJ |
| description | BackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese. Here, we aimed to examine the association between serum furin and fasting glucose in Chinese adults.MethodsSerum furin and fasting plasma glucose were assayed for 2,172 participants (mean aged 53 years, 38% men) in the Gusu cohort. A median regression model was applied to examine the association between serum furin and fasting glucose, adjusting for age, sex, education level, cigarette smoking, alcohol drinking, obesity, blood pressure, and lipids. To facilitate data interpretation, the association between serum furin and prevalent diabetes was also examined.ResultsSerum furin was negatively associated with fasting glucose (β=-0.18, P<0.001 for log-furin). In participants with diabetes, serum furin was significantly lower than those with normal glucose (median: 0.90 ng/mL vs. 1.05 ng/mL, P=0.001). Compared with participants in the highest quartile of serum furin, those in the lowest quartile had 42% and 80% increased risk of prevalent prediabetes (OR=1.42, 95%CI: 1.05-1.92, P=0.023) and diabetes (OR=1.80, 95%CI: 1.13-2.91, P=0.015), respectively.ConclusionsSerum furin was negatively associated with prediabetes and diabetes in Chinese adults. Our findings suggest that serum furin may be a risk factor or a biomarker of diabetes. |
| first_indexed | 2024-12-17T23:37:26Z |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-17T23:37:26Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-afc82794059b42eb896895997f98482d2022-12-21T21:28:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-01-011210.3389/fendo.2021.781890781890Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese AdultsYan He0Hanyun Zhu1Min Zhang2Jing Li3Shengqi Ma4Yin Lu5Linan Chen6Mingzhi Zhang7Hao Peng8Hao Peng9Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, ChinaDepartment of Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, ChinaCentral Office, Suzhou National New and Hi-Tech Industrial Development Zone Center for Disease Control and Prevention, Suzhou, ChinaDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, ChinaDepartment of Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, ChinaDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, ChinaDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, ChinaDepartment of Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, ChinaDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, ChinaJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Suzhou, ChinaBackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese. Here, we aimed to examine the association between serum furin and fasting glucose in Chinese adults.MethodsSerum furin and fasting plasma glucose were assayed for 2,172 participants (mean aged 53 years, 38% men) in the Gusu cohort. A median regression model was applied to examine the association between serum furin and fasting glucose, adjusting for age, sex, education level, cigarette smoking, alcohol drinking, obesity, blood pressure, and lipids. To facilitate data interpretation, the association between serum furin and prevalent diabetes was also examined.ResultsSerum furin was negatively associated with fasting glucose (β=-0.18, P<0.001 for log-furin). In participants with diabetes, serum furin was significantly lower than those with normal glucose (median: 0.90 ng/mL vs. 1.05 ng/mL, P=0.001). Compared with participants in the highest quartile of serum furin, those in the lowest quartile had 42% and 80% increased risk of prevalent prediabetes (OR=1.42, 95%CI: 1.05-1.92, P=0.023) and diabetes (OR=1.80, 95%CI: 1.13-2.91, P=0.015), respectively.ConclusionsSerum furin was negatively associated with prediabetes and diabetes in Chinese adults. Our findings suggest that serum furin may be a risk factor or a biomarker of diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2021.781890/fullfurindiabetesfasting plasma glucoseChinesecross-sectional studyrisk factor |
| spellingShingle | Yan He Hanyun Zhu Min Zhang Jing Li Shengqi Ma Yin Lu Linan Chen Mingzhi Zhang Hao Peng Hao Peng Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults Frontiers in Endocrinology furin diabetes fasting plasma glucose Chinese cross-sectional study risk factor |
| title | Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults |
| title_full | Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults |
| title_fullStr | Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults |
| title_full_unstemmed | Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults |
| title_short | Association Between Serum Furin and Fasting Glucose: A Cross-Sectional Study in Chinese Adults |
| title_sort | association between serum furin and fasting glucose a cross sectional study in chinese adults |
| topic | furin diabetes fasting plasma glucose Chinese cross-sectional study risk factor |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.781890/full |
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