Metformin attenuates diabetes-induced osteopenia in rats is associated with down-regulation of the RAGE-JAK2-STAT1 signal axis

Metformin attenuates diabetes-induced osteopenia in rats is associated with down-regulation of the RAGE-JAK2-STAT1 signal axis

Background: Osteopenia and fragile fractures are diabetes-associated complications. Many hypoglycemic drugs have effects on bone metabolism. Metformin, as is a prescribed medication for type 2 diabetes mellitus (T2DM), had been reported to have osteoprotective effects beyond its hypoglycemic effect,...

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Bibliographic Details
Main Authors: Rui Lin, Bilian Xu, Zhiqiang Ye, Yin Gao, Haiping Fang, Jintong Song, Dahong Liang, Lingna Liu, Zilong Hu, Min Zhang, Jinsong Wei, Feifu Deng, Xiangxin Zhong, Liao Cui, Yanzhi Liu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Orthopaedic Translation
Subjects:
Diabetes
Bone
Osteoporosis
Osteopenia
Metformin
Fragility
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000293

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http://www.sciencedirect.com/science/article/pii/S2214031X23000293

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