Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease
Several molecular technologies aimed at regulating gene expression that have been recently developed as a strategy to combat inflammatory and neoplastic diseases. Among these, antisense technology is a specific, rapid, and potentially high-throughput approach for inhibiting gene expression through r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00305/full |
| _version_ | 1818469185484750848 |
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| author | Davide Di Fusco Vincenzo Dinallo Irene Marafini Michele M. Figliuzzi Barbara Romano Giovanni Monteleone |
| author_facet | Davide Di Fusco Vincenzo Dinallo Irene Marafini Michele M. Figliuzzi Barbara Romano Giovanni Monteleone |
| author_sort | Davide Di Fusco |
| collection | DOAJ |
| description | Several molecular technologies aimed at regulating gene expression that have been recently developed as a strategy to combat inflammatory and neoplastic diseases. Among these, antisense technology is a specific, rapid, and potentially high-throughput approach for inhibiting gene expression through recognition of cellular RNAs. Advances in the understanding of the molecular mechanisms that drive tissue damage in different inflammatory diseases, including Crohn’s disease (CD) and ulcerative colitis (UC), the two major inflammatory bowel diseases (IBDs) in humans, have facilitated the identification of novel druggable targets and offered interesting therapeutic perspectives for the treatment of patients. This short review provides a comprehensive understanding of the basic concepts underlying the mechanism of action of the oligonucleotide therapeutics, and summarizes the available pre-clinical and clinical data for oligonucleotide-based therapy in IBD. |
| first_indexed | 2024-04-13T21:20:41Z |
| format | Article |
| id | doaj.art-afcc5fb47088448e942a33fe446ba1c7 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T21:20:41Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-afcc5fb47088448e942a33fe446ba1c72022-12-22T02:29:31ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-03-011010.3389/fphar.2019.00305440751Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel DiseaseDavide Di Fusco0Vincenzo Dinallo1Irene Marafini2Michele M. Figliuzzi3Barbara Romano4Giovanni Monteleone5Department of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, ItalyDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, ItalyDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, ItalyDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, ItalyDepartment of Pharmacy, School of Medicine and Surgery, University of Naples “Federico II”, Naples, ItalyDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, ItalySeveral molecular technologies aimed at regulating gene expression that have been recently developed as a strategy to combat inflammatory and neoplastic diseases. Among these, antisense technology is a specific, rapid, and potentially high-throughput approach for inhibiting gene expression through recognition of cellular RNAs. Advances in the understanding of the molecular mechanisms that drive tissue damage in different inflammatory diseases, including Crohn’s disease (CD) and ulcerative colitis (UC), the two major inflammatory bowel diseases (IBDs) in humans, have facilitated the identification of novel druggable targets and offered interesting therapeutic perspectives for the treatment of patients. This short review provides a comprehensive understanding of the basic concepts underlying the mechanism of action of the oligonucleotide therapeutics, and summarizes the available pre-clinical and clinical data for oligonucleotide-based therapy in IBD.https://www.frontiersin.org/article/10.3389/fphar.2019.00305/fullinflammatory bowel diseaseulcerative colitisCrohn’s diseaseantisense oligonucleotideRNA interference |
| spellingShingle | Davide Di Fusco Vincenzo Dinallo Irene Marafini Michele M. Figliuzzi Barbara Romano Giovanni Monteleone Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease Frontiers in Pharmacology inflammatory bowel disease ulcerative colitis Crohn’s disease antisense oligonucleotide RNA interference |
| title | Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease |
| title_full | Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease |
| title_fullStr | Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease |
| title_full_unstemmed | Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease |
| title_short | Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease |
| title_sort | antisense oligonucleotide basic concepts and therapeutic application in inflammatory bowel disease |
| topic | inflammatory bowel disease ulcerative colitis Crohn’s disease antisense oligonucleotide RNA interference |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00305/full |
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