A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances
Maheeba Abdulla,1 Nafeesa Mohammed2 1Internal Medicine Department, Ibn AlNafees Hospital, Arabian Gulf University, Manama, Bahrain; 2Salmaniya Medical Complex, Manama, BahrainCorrespondence: Maheeba Abdulla, Consultant Gastroenterologist, Internal Medicine Department, Ibn AlNafees Hospital, Arabian...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-09-01
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| Series: | Biologics: Targets & Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-review-on-inflammatory-bowel-diseases-recent-molecular-pathophysiolo-peer-reviewed-fulltext-article-BTT |
| _version_ | 1828145110459613184 |
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| author | Abdulla M Mohammed N |
| author_facet | Abdulla M Mohammed N |
| author_sort | Abdulla M |
| collection | DOAJ |
| description | Maheeba Abdulla,1 Nafeesa Mohammed2 1Internal Medicine Department, Ibn AlNafees Hospital, Arabian Gulf University, Manama, Bahrain; 2Salmaniya Medical Complex, Manama, BahrainCorrespondence: Maheeba Abdulla, Consultant Gastroenterologist, Internal Medicine Department, Ibn AlNafees Hospital, Arabian Gulf University, Manama, Bahrain, Email amaheeba@hotmail.comAbstract: Inflammatory bowel diseases are considered immune disorders with a complex genetic architecture involving constantly changing endogenous and exogenous factors. The rapid evolution of genomic technologies and the emergence of newly discovered molecular actors are compelling the research community to reevaluate the knowledge and molecular processes. The human intestinal tract contains intestinal human microbiota consisting of commensal, pathogenic, and symbiotic strains leading to immune responses that can contribute and lead to both systemic and intestinal disorders including IBD. In this review, we attempted to highlight some updates of the new IBD features related to genomics, microbiota, new emerging therapies and some major established IBD risk factors.Keywords: inflammatory bowel disease, immune disorders, genomics, ulcerative colitis, Crohn’s disease |
| first_indexed | 2024-04-11T20:28:26Z |
| format | Article |
| id | doaj.art-afcc78d324964065916acef06e526d24 |
| institution | Directory Open Access Journal |
| issn | 1177-5491 |
| language | English |
| last_indexed | 2024-04-11T20:28:26Z |
| publishDate | 2022-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Biologics: Targets & Therapy |
| spelling | doaj.art-afcc78d324964065916acef06e526d242022-12-22T04:04:36ZengDove Medical PressBiologics: Targets & Therapy1177-54912022-09-01Volume 1612914078150A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology AdvancesAbdulla MMohammed NMaheeba Abdulla,1 Nafeesa Mohammed2 1Internal Medicine Department, Ibn AlNafees Hospital, Arabian Gulf University, Manama, Bahrain; 2Salmaniya Medical Complex, Manama, BahrainCorrespondence: Maheeba Abdulla, Consultant Gastroenterologist, Internal Medicine Department, Ibn AlNafees Hospital, Arabian Gulf University, Manama, Bahrain, Email amaheeba@hotmail.comAbstract: Inflammatory bowel diseases are considered immune disorders with a complex genetic architecture involving constantly changing endogenous and exogenous factors. The rapid evolution of genomic technologies and the emergence of newly discovered molecular actors are compelling the research community to reevaluate the knowledge and molecular processes. The human intestinal tract contains intestinal human microbiota consisting of commensal, pathogenic, and symbiotic strains leading to immune responses that can contribute and lead to both systemic and intestinal disorders including IBD. In this review, we attempted to highlight some updates of the new IBD features related to genomics, microbiota, new emerging therapies and some major established IBD risk factors.Keywords: inflammatory bowel disease, immune disorders, genomics, ulcerative colitis, Crohn’s diseasehttps://www.dovepress.com/a-review-on-inflammatory-bowel-diseases-recent-molecular-pathophysiolo-peer-reviewed-fulltext-article-BTTinflammatory bowel diseaseimmune disordersgenomicsulcerative colitiscrohn’s disease. |
| spellingShingle | Abdulla M Mohammed N A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances Biologics: Targets & Therapy inflammatory bowel disease immune disorders genomics ulcerative colitis crohn’s disease. |
| title | A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances |
| title_full | A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances |
| title_fullStr | A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances |
| title_full_unstemmed | A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances |
| title_short | A Review on Inflammatory Bowel Diseases: Recent Molecular Pathophysiology Advances |
| title_sort | review on inflammatory bowel diseases recent molecular pathophysiology advances |
| topic | inflammatory bowel disease immune disorders genomics ulcerative colitis crohn’s disease. |
| url | https://www.dovepress.com/a-review-on-inflammatory-bowel-diseases-recent-molecular-pathophysiolo-peer-reviewed-fulltext-article-BTT |
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