Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF

Culin5 aggravates hypoxic pulmonary hypertension by activating TRAF6/NF-κB/HIF-1α/VEGF

Summary: Hypoxic pulmonary hypertension (HPH) lacks effective pharmacologic treatments. Microarray-based gene expression indicates the crucial role of Cullin 5 (Cul 5) in HPH. This study showed that Cul 5 was upregulated in HPH patients and a murine model of HPH. In vitro, Cul 5 promoted the angioge...

Full description

Bibliographic Details
Main Authors: Lei Wang, Jing Huang, Ruoyang Zhang, Muzhi Zhang, Yu Guo, Yang Liu, Cong Li, Wei Wang, Sun Ying, Jie Liu, Chen Wang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:iScience
Subjects:
Cardiovascular medicine
Molecular physiology
Molecular medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223022769

Internet

http://www.sciencedirect.com/science/article/pii/S2589004223022769

Similar Items