The biomechanical implications of neck position in cervical contusion animal models of SCI
Large animal contusion models of spinal cord injury are an essential precursor to developing and evaluating treatment options for human spinal cord injury. Reducing variability in these experiments has been a recent focus as it increases the sensitivity with which treatment effects can be detected w...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1152472/full |
| _version_ | 1827278281036005376 |
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| author | Numaira Obaid Numaira Obaid Kazuhito Morioka Kazuhito Morioka Eleni Sinopoulou Yvette S. Nout-Lomas Ernesto Salegio Jacqueline C. Bresnahan Michael S. Beattie Carolyn J. Sparrey Carolyn J. Sparrey |
| author_facet | Numaira Obaid Numaira Obaid Kazuhito Morioka Kazuhito Morioka Eleni Sinopoulou Yvette S. Nout-Lomas Ernesto Salegio Jacqueline C. Bresnahan Michael S. Beattie Carolyn J. Sparrey Carolyn J. Sparrey |
| author_sort | Numaira Obaid |
| collection | DOAJ |
| description | Large animal contusion models of spinal cord injury are an essential precursor to developing and evaluating treatment options for human spinal cord injury. Reducing variability in these experiments has been a recent focus as it increases the sensitivity with which treatment effects can be detected while simultaneously decreasing the number of animals required in a study. Here, we conducted a detailed review to explore if head and neck positioning in a cervical contusion model of spinal cord injury could be a factor impacting the biomechanics of a spinal cord injury, and thus, the resulting outcomes. By reviewing existing literature, we found evidence that animal head/neck positioning affects the exposed level of the spinal cord, morphology of the spinal cord, tissue mechanics and as a result the biomechanics of a cervical spinal cord injury. We posited that neck position could be a hidden factor contributing to variability. Our results indicate that neck positioning is an important factor in studying biomechanics, and that reporting these values can improve inter-study consistency and comparability and that further work needs to be done to standardize positioning for cervical spinal cord contusion injury models. |
| first_indexed | 2024-03-13T07:05:45Z |
| format | Article |
| id | doaj.art-afcd16c552a1459d80d3b80e17d4ac12 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-24T07:52:28Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-afcd16c552a1459d80d3b80e17d4ac122024-04-18T10:11:06ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-06-011410.3389/fneur.2023.11524721152472The biomechanical implications of neck position in cervical contusion animal models of SCINumaira Obaid0Numaira Obaid1Kazuhito Morioka2Kazuhito Morioka3Eleni Sinopoulou4Yvette S. Nout-Lomas5Ernesto Salegio6Jacqueline C. Bresnahan7Michael S. Beattie8Carolyn J. Sparrey9Carolyn J. Sparrey10Mechatronic Systems Engineering, Simon Fraser University, Surrey, BC, CanadaInternational Collaboration on Repair Discoveries (ICORD), Vancouver, BC, CanadaDepartment of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA, United StatesBrain and Spinal Injury Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United StatesCenter for Neural Repair, University of California, San Diego, San Diego, CA, United StatesDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO, United StatesUniversity of California, Davis, Davis, CA, United StatesBrain and Spinal Injury Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United StatesBrain and Spinal Injury Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United StatesMechatronic Systems Engineering, Simon Fraser University, Surrey, BC, CanadaInternational Collaboration on Repair Discoveries (ICORD), Vancouver, BC, CanadaLarge animal contusion models of spinal cord injury are an essential precursor to developing and evaluating treatment options for human spinal cord injury. Reducing variability in these experiments has been a recent focus as it increases the sensitivity with which treatment effects can be detected while simultaneously decreasing the number of animals required in a study. Here, we conducted a detailed review to explore if head and neck positioning in a cervical contusion model of spinal cord injury could be a factor impacting the biomechanics of a spinal cord injury, and thus, the resulting outcomes. By reviewing existing literature, we found evidence that animal head/neck positioning affects the exposed level of the spinal cord, morphology of the spinal cord, tissue mechanics and as a result the biomechanics of a cervical spinal cord injury. We posited that neck position could be a hidden factor contributing to variability. Our results indicate that neck positioning is an important factor in studying biomechanics, and that reporting these values can improve inter-study consistency and comparability and that further work needs to be done to standardize positioning for cervical spinal cord contusion injury models.https://www.frontiersin.org/articles/10.3389/fneur.2023.1152472/fullspinal cord injurysurgical positioningcontusion modelsanimal modelscontusion injury |
| spellingShingle | Numaira Obaid Numaira Obaid Kazuhito Morioka Kazuhito Morioka Eleni Sinopoulou Yvette S. Nout-Lomas Ernesto Salegio Jacqueline C. Bresnahan Michael S. Beattie Carolyn J. Sparrey Carolyn J. Sparrey The biomechanical implications of neck position in cervical contusion animal models of SCI Frontiers in Neurology spinal cord injury surgical positioning contusion models animal models contusion injury |
| title | The biomechanical implications of neck position in cervical contusion animal models of SCI |
| title_full | The biomechanical implications of neck position in cervical contusion animal models of SCI |
| title_fullStr | The biomechanical implications of neck position in cervical contusion animal models of SCI |
| title_full_unstemmed | The biomechanical implications of neck position in cervical contusion animal models of SCI |
| title_short | The biomechanical implications of neck position in cervical contusion animal models of SCI |
| title_sort | biomechanical implications of neck position in cervical contusion animal models of sci |
| topic | spinal cord injury surgical positioning contusion models animal models contusion injury |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1152472/full |
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