Maternal common mental disorders and infant development in Ethiopia: the P-MaMiE Birth Cohort
<p>Abstract</p> <p>Background</p> <p>Chronicity and severity of early exposure to maternal common mental disorders (CMD) has been associated with poorer infant development in high-income countries. In low- and middle-income countries (LAMICs), perinatal CMD is inconsist...
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| Format: | Article |
| Language: | English |
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BMC
2010-11-01
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| Series: | BMC Public Health |
| Online Access: | http://www.biomedcentral.com/1471-2458/10/693 |
| _version_ | 1818483744451854336 |
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| author | Baheretibeb Yonas Worku Bogale Tomlinson Mark Hanlon Charlotte Medhin Girmay Servili Chiara Dewey Michael Alem Atalay Prince Martin |
| author_facet | Baheretibeb Yonas Worku Bogale Tomlinson Mark Hanlon Charlotte Medhin Girmay Servili Chiara Dewey Michael Alem Atalay Prince Martin |
| author_sort | Baheretibeb Yonas |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Chronicity and severity of early exposure to maternal common mental disorders (CMD) has been associated with poorer infant development in high-income countries. In low- and middle-income countries (LAMICs), perinatal CMD is inconsistently associated with infant development, but the impact of severity and persistence has not been examined.</p> <p>Methods</p> <p>A nested population-based cohort of 258 pregnant women was identified from the Perinatal Maternal Mental Disorder in Ethiopia (<it>P-MaMiE</it>) study, and 194 (75.2%) were successfully followed up until the infants were 12 months of age. Maternal CMD was measured in pregnancy and at two and 12 months postnatal using the WHO Self-Reporting Questionnaire, validated for use in this setting. Infant outcomes were evaluated using the Bayley Scales of Infant Development.</p> <p>Results</p> <p>Antenatal maternal CMD symptoms were associated with poorer infant motor development (<inline-formula><m:math name="1471-2458-10-693-i1" xmlns:m="http://www.w3.org/1998/Math/MathML"><m:mover accent="true"><m:mi>β</m:mi><m:mo>^</m:mo></m:mover></m:math></inline-formula> -0.20; 95% CI: -0.37 to -0.03), but this became non-significant after adjusting for confounders. Postnatal CMD symptoms were not associated with any domain of infant development. There was evidence of a dose-response relationship between the number of time-points at which the mother had high levels of CMD symptoms (SRQ ≥ 6) and impaired infant motor development (<inline-formula><m:math xmlns:m="http://www.w3.org/1998/Math/MathML" name="1471-2458-10-693-i1"><m:mover accent="true"><m:mi>β</m:mi><m:mo>^</m:mo></m:mover></m:math></inline-formula> = -0.80; 95%CI -2.24, 0.65 for ante- or postnatal CMD only, <inline-formula><m:math xmlns:m="http://www.w3.org/1998/Math/MathML" name="1471-2458-10-693-i1"><m:mover accent="true"><m:mi>β</m:mi><m:mo>^</m:mo></m:mover></m:math></inline-formula> = -4.19; 95%CI -8.60, 0.21 for ante- and postnatal CMD, compared to no CMD; test-for-trend χ<sup>2</sup>13.08(1), p < 0.001). Although this association became non-significant in the fully adjusted model, the <inline-formula><m:math xmlns:m="http://www.w3.org/1998/Math/MathML" name="1471-2458-10-693-i1"><m:mover accent="true"><m:mi>β</m:mi><m:mo>^</m:mo></m:mover></m:math></inline-formula> coefficients were unchanged indicating that the relationship was not confounded. In multivariable analyses, lower socio-economic status and lower infant weight-for-age were associated with significantly lower scores on both motor and cognitive developmental scales. Maternal experience of physical violence was significantly associated with impaired cognitive development.</p> <p>Conclusions</p> <p>The study supports the hypothesis that it is the accumulation of risk exposures across time rather than early exposure to maternal CMD per se that is more likely to affect child development. Further investigation of the impact of chronicity of maternal CMD upon child development in LAMICs is indicated. In the Ethiopian setting, poverty, interpersonal violence and infant undernutrition should be targets for interventions to reduce the loss of child developmental potential.</p> |
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| id | doaj.art-afcda46828264c2ca5eca435f1f9ce7a |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-10T15:46:00Z |
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| spelling | doaj.art-afcda46828264c2ca5eca435f1f9ce7a2022-12-22T01:42:57ZengBMCBMC Public Health1471-24582010-11-0110169310.1186/1471-2458-10-693Maternal common mental disorders and infant development in Ethiopia: the P-MaMiE Birth CohortBaheretibeb YonasWorku BogaleTomlinson MarkHanlon CharlotteMedhin GirmayServili ChiaraDewey MichaelAlem AtalayPrince Martin<p>Abstract</p> <p>Background</p> <p>Chronicity and severity of early exposure to maternal common mental disorders (CMD) has been associated with poorer infant development in high-income countries. In low- and middle-income countries (LAMICs), perinatal CMD is inconsistently associated with infant development, but the impact of severity and persistence has not been examined.</p> <p>Methods</p> <p>A nested population-based cohort of 258 pregnant women was identified from the Perinatal Maternal Mental Disorder in Ethiopia (<it>P-MaMiE</it>) study, and 194 (75.2%) were successfully followed up until the infants were 12 months of age. Maternal CMD was measured in pregnancy and at two and 12 months postnatal using the WHO Self-Reporting Questionnaire, validated for use in this setting. Infant outcomes were evaluated using the Bayley Scales of Infant Development.</p> <p>Results</p> <p>Antenatal maternal CMD symptoms were associated with poorer infant motor development (<inline-formula><m:math name="1471-2458-10-693-i1" xmlns:m="http://www.w3.org/1998/Math/MathML"><m:mover accent="true"><m:mi>β</m:mi><m:mo>^</m:mo></m:mover></m:math></inline-formula> -0.20; 95% CI: -0.37 to -0.03), but this became non-significant after adjusting for confounders. Postnatal CMD symptoms were not associated with any domain of infant development. There was evidence of a dose-response relationship between the number of time-points at which the mother had high levels of CMD symptoms (SRQ ≥ 6) and impaired infant motor development (<inline-formula><m:math xmlns:m="http://www.w3.org/1998/Math/MathML" name="1471-2458-10-693-i1"><m:mover accent="true"><m:mi>β</m:mi><m:mo>^</m:mo></m:mover></m:math></inline-formula> = -0.80; 95%CI -2.24, 0.65 for ante- or postnatal CMD only, <inline-formula><m:math xmlns:m="http://www.w3.org/1998/Math/MathML" name="1471-2458-10-693-i1"><m:mover accent="true"><m:mi>β</m:mi><m:mo>^</m:mo></m:mover></m:math></inline-formula> = -4.19; 95%CI -8.60, 0.21 for ante- and postnatal CMD, compared to no CMD; test-for-trend χ<sup>2</sup>13.08(1), p < 0.001). Although this association became non-significant in the fully adjusted model, the <inline-formula><m:math xmlns:m="http://www.w3.org/1998/Math/MathML" name="1471-2458-10-693-i1"><m:mover accent="true"><m:mi>β</m:mi><m:mo>^</m:mo></m:mover></m:math></inline-formula> coefficients were unchanged indicating that the relationship was not confounded. In multivariable analyses, lower socio-economic status and lower infant weight-for-age were associated with significantly lower scores on both motor and cognitive developmental scales. Maternal experience of physical violence was significantly associated with impaired cognitive development.</p> <p>Conclusions</p> <p>The study supports the hypothesis that it is the accumulation of risk exposures across time rather than early exposure to maternal CMD per se that is more likely to affect child development. Further investigation of the impact of chronicity of maternal CMD upon child development in LAMICs is indicated. In the Ethiopian setting, poverty, interpersonal violence and infant undernutrition should be targets for interventions to reduce the loss of child developmental potential.</p>http://www.biomedcentral.com/1471-2458/10/693 |
| spellingShingle | Baheretibeb Yonas Worku Bogale Tomlinson Mark Hanlon Charlotte Medhin Girmay Servili Chiara Dewey Michael Alem Atalay Prince Martin Maternal common mental disorders and infant development in Ethiopia: the P-MaMiE Birth Cohort BMC Public Health |
| title | Maternal common mental disorders and infant development in Ethiopia: the P-MaMiE Birth Cohort |
| title_full | Maternal common mental disorders and infant development in Ethiopia: the P-MaMiE Birth Cohort |
| title_fullStr | Maternal common mental disorders and infant development in Ethiopia: the P-MaMiE Birth Cohort |
| title_full_unstemmed | Maternal common mental disorders and infant development in Ethiopia: the P-MaMiE Birth Cohort |
| title_short | Maternal common mental disorders and infant development in Ethiopia: the P-MaMiE Birth Cohort |
| title_sort | maternal common mental disorders and infant development in ethiopia the p mamie birth cohort |
| url | http://www.biomedcentral.com/1471-2458/10/693 |
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