Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon
Malaria is still a threat to public health as it remains the first endemic disease in the world. It is a pervasive parasitic disease in tropical and subtropical regions where asymptomatic malaria infection among humans serves as a significant reservoir for transmission. A rapid and correct diagnosis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/11/960 |
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| author | Nji Mbuh Akindeh Lesley Ngum Ngum Peter Thelma Ngwa Niba Innocent Mbulli Ali Ornella Laetitia Oben Ayem Jean Paul Kengne Chedjou Calvino Tah Fomboh Aristid Herve Mbange Ekollo Cyrille Mbanwi Mbu’u Wilfred Fon Mbacham |
| author_facet | Nji Mbuh Akindeh Lesley Ngum Ngum Peter Thelma Ngwa Niba Innocent Mbulli Ali Ornella Laetitia Oben Ayem Jean Paul Kengne Chedjou Calvino Tah Fomboh Aristid Herve Mbange Ekollo Cyrille Mbanwi Mbu’u Wilfred Fon Mbacham |
| author_sort | Nji Mbuh Akindeh |
| collection | DOAJ |
| description | Malaria is still a threat to public health as it remains the first endemic disease in the world. It is a pervasive parasitic disease in tropical and subtropical regions where asymptomatic malaria infection among humans serves as a significant reservoir for transmission. A rapid and correct diagnosis is considered to be an important strategy in the control of the disease especially in children, who are the most vulnerable group. This study assessed the prevalence of asymptomatic malaria in children at the Nkolbisson health area in Yaoundé, Cameroon. A cross-sectional study design and a convenience sampling plan were used. A total of 127 participants were recruited after informed and signed consent from parents and/or guardians. Blood samples were collected by finger-pricking and venipuncture from children aged 6 months to 10 years and then screened for asymptomatic parasitemia by a rapid diagnostic test (RDT), light microscopy (LM) staining with Giemsa and 18S rRNA polymerase chain reaction (PCR) for speciation. The data were analyzed using SPSS version 20 software. The study identified 85 children who were positive from the PCR, 95 positive from the RDT and 71 from the LM, revealing a malaria prevalence of 66.9%, 74.8% and 55.9%, respectively. The prevalence was not observed to be dependent on the sex and age group of the participants. <i>Plasmodium falciparum</i> was the predominant species followed by <i>Plasmodium malariae</i> and then <i>Plasmodium ovale</i>. The RDT and LM had the same sensitivity (90.6%) with a slight difference in their specificity (RDT: 57.1%; LM: 54.8%). The RDT also demonstrated higher positive and negative predictive values compared with those of the LM. |
| first_indexed | 2024-03-10T05:36:36Z |
| format | Article |
| id | doaj.art-afd194362a77404fa4a2d70606da023a |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T05:36:36Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-afd194362a77404fa4a2d70606da023a2023-11-22T22:54:29ZengMDPI AGChildren2227-90672021-10-0181196010.3390/children8110960Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, CameroonNji Mbuh Akindeh0Lesley Ngum Ngum1Peter Thelma Ngwa Niba2Innocent Mbulli Ali3Ornella Laetitia Oben Ayem4Jean Paul Kengne Chedjou5Calvino Tah Fomboh6Aristid Herve Mbange Ekollo7Cyrille Mbanwi Mbu’u8Wilfred Fon Mbacham9Biotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonBiotechnology Center, University of Yaoundé I, Messa, Yaoundé P.O. Box 3851, CameroonMalaria is still a threat to public health as it remains the first endemic disease in the world. It is a pervasive parasitic disease in tropical and subtropical regions where asymptomatic malaria infection among humans serves as a significant reservoir for transmission. A rapid and correct diagnosis is considered to be an important strategy in the control of the disease especially in children, who are the most vulnerable group. This study assessed the prevalence of asymptomatic malaria in children at the Nkolbisson health area in Yaoundé, Cameroon. A cross-sectional study design and a convenience sampling plan were used. A total of 127 participants were recruited after informed and signed consent from parents and/or guardians. Blood samples were collected by finger-pricking and venipuncture from children aged 6 months to 10 years and then screened for asymptomatic parasitemia by a rapid diagnostic test (RDT), light microscopy (LM) staining with Giemsa and 18S rRNA polymerase chain reaction (PCR) for speciation. The data were analyzed using SPSS version 20 software. The study identified 85 children who were positive from the PCR, 95 positive from the RDT and 71 from the LM, revealing a malaria prevalence of 66.9%, 74.8% and 55.9%, respectively. The prevalence was not observed to be dependent on the sex and age group of the participants. <i>Plasmodium falciparum</i> was the predominant species followed by <i>Plasmodium malariae</i> and then <i>Plasmodium ovale</i>. The RDT and LM had the same sensitivity (90.6%) with a slight difference in their specificity (RDT: 57.1%; LM: 54.8%). The RDT also demonstrated higher positive and negative predictive values compared with those of the LM.https://www.mdpi.com/2227-9067/8/11/960asymptomatic malariachildren prevalence<i>Plasmodium</i> speciesYaoundéCameroon |
| spellingShingle | Nji Mbuh Akindeh Lesley Ngum Ngum Peter Thelma Ngwa Niba Innocent Mbulli Ali Ornella Laetitia Oben Ayem Jean Paul Kengne Chedjou Calvino Tah Fomboh Aristid Herve Mbange Ekollo Cyrille Mbanwi Mbu’u Wilfred Fon Mbacham Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon Children asymptomatic malaria children prevalence <i>Plasmodium</i> species Yaoundé Cameroon |
| title | Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon |
| title_full | Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon |
| title_fullStr | Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon |
| title_full_unstemmed | Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon |
| title_short | Assessing Asymptomatic Malaria Carriage of <i>Plasmodium falciparum</i> and Non-<i>falciparum</i> Species in Children Resident in Nkolbisson, Yaoundé, Cameroon |
| title_sort | assessing asymptomatic malaria carriage of i plasmodium falciparum i and non i falciparum i species in children resident in nkolbisson yaounde cameroon |
| topic | asymptomatic malaria children prevalence <i>Plasmodium</i> species Yaoundé Cameroon |
| url | https://www.mdpi.com/2227-9067/8/11/960 |
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