The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review
Interferon-beta (IFN-β) for Multiple Sclerosis (MS) is turning 30. The COVID-19 pandemic rejuvenated the interest in interferon biology in health and disease, opening translational opportunities beyond neuroinflammation. The antiviral properties of this molecule are in accord with the hypothesis of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161849/full |
| _version_ | 1797813682634227712 |
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| author | Gianmarco Bellucci Angela Albanese Angela Albanese Caterina Rizzi Virginia Rinaldi Marco Salvetti Marco Salvetti Giovanni Ristori Giovanni Ristori |
| author_facet | Gianmarco Bellucci Angela Albanese Angela Albanese Caterina Rizzi Virginia Rinaldi Marco Salvetti Marco Salvetti Giovanni Ristori Giovanni Ristori |
| author_sort | Gianmarco Bellucci |
| collection | DOAJ |
| description | Interferon-beta (IFN-β) for Multiple Sclerosis (MS) is turning 30. The COVID-19 pandemic rejuvenated the interest in interferon biology in health and disease, opening translational opportunities beyond neuroinflammation. The antiviral properties of this molecule are in accord with the hypothesis of a viral etiology of MS, for which a credible culprit has been identified in the Epstein-Barr Virus. Likely, IFNs are crucial in the acute phase of SARS-CoV-2 infection, as demonstrated by inherited and acquired impairments of the interferon response that predispose to a severe COVID-19 course. Accordingly, IFN-β exerted protection against SARS-CoV-2 in people with MS (pwMS). In this viewpoint, we summarize the evidence on IFN-β mechanisms of action in MS with a focus on its antiviral properties, especially against EBV. We synopsize the role of IFNs in COVID-19 and the opportunities and challenges of IFN-β usage for this condition. Finally, we leverage the lessons learned in the pandemic to suggest a role of IFN-β in long-COVID-19 and in special MS subpopulations. |
| first_indexed | 2024-03-13T07:56:24Z |
| format | Article |
| id | doaj.art-afd28935dd1849e3a12eb0f6978abe8c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T07:56:24Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-afd28935dd1849e3a12eb0f6978abe8c2023-06-02T05:22:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.11618491161849The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature reviewGianmarco Bellucci0Angela Albanese1Angela Albanese2Caterina Rizzi3Virginia Rinaldi4Marco Salvetti5Marco Salvetti6Giovanni Ristori7Giovanni Ristori8Department of Neurosciences, Mental Health and Sensory Organs, Centre for Experimental Neurological Therapies (CENTERS), Sapienza University of Rome, Rome, ItalyMerck Serono S.p.A., An Affiliate of Merck KGaA, Rome, ItalyDepartment of Health Sciences, University of Genoa, Genoa, ItalyMerck Serono S.p.A., An Affiliate of Merck KGaA, Rome, ItalyDepartment of Neurosciences, Mental Health and Sensory Organs, Centre for Experimental Neurological Therapies (CENTERS), Sapienza University of Rome, Rome, ItalyDepartment of Neurosciences, Mental Health and Sensory Organs, Centre for Experimental Neurological Therapies (CENTERS), Sapienza University of Rome, Rome, ItalyIstituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Neurologico Mediterraneo Neuromed, Pozzilli, ItalyDepartment of Neurosciences, Mental Health and Sensory Organs, Centre for Experimental Neurological Therapies (CENTERS), Sapienza University of Rome, Rome, ItalyNeuroimmunology Unit, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Rome, ItalyInterferon-beta (IFN-β) for Multiple Sclerosis (MS) is turning 30. The COVID-19 pandemic rejuvenated the interest in interferon biology in health and disease, opening translational opportunities beyond neuroinflammation. The antiviral properties of this molecule are in accord with the hypothesis of a viral etiology of MS, for which a credible culprit has been identified in the Epstein-Barr Virus. Likely, IFNs are crucial in the acute phase of SARS-CoV-2 infection, as demonstrated by inherited and acquired impairments of the interferon response that predispose to a severe COVID-19 course. Accordingly, IFN-β exerted protection against SARS-CoV-2 in people with MS (pwMS). In this viewpoint, we summarize the evidence on IFN-β mechanisms of action in MS with a focus on its antiviral properties, especially against EBV. We synopsize the role of IFNs in COVID-19 and the opportunities and challenges of IFN-β usage for this condition. Finally, we leverage the lessons learned in the pandemic to suggest a role of IFN-β in long-COVID-19 and in special MS subpopulations.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161849/fullmultiple Sclerosisinterferon βSARS-CoV-2Epstein-Barr virusimmune cells |
| spellingShingle | Gianmarco Bellucci Angela Albanese Angela Albanese Caterina Rizzi Virginia Rinaldi Marco Salvetti Marco Salvetti Giovanni Ristori Giovanni Ristori The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review Frontiers in Immunology multiple Sclerosis interferon β SARS-CoV-2 Epstein-Barr virus immune cells |
| title | The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review |
| title_full | The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review |
| title_fullStr | The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review |
| title_full_unstemmed | The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review |
| title_short | The value of Interferon β in multiple sclerosis and novel opportunities for its anti-viral activity: a narrative literature review |
| title_sort | value of interferon β in multiple sclerosis and novel opportunities for its anti viral activity a narrative literature review |
| topic | multiple Sclerosis interferon β SARS-CoV-2 Epstein-Barr virus immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161849/full |
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