Involvement of hydrogen sulfide in the progression of renal fibrosis
Abstract. Objective. Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2019-12-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000000537 |
| _version_ | 1818821775162605568 |
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| author | Yu Wang Qi-Qi Xing Jing-Ke Tu Wen-Bin Tang Xiang-Ning Yuan Yan-Yun Xie Wei Wang Zhang-Zhe Peng Ling Huang Hui Xu Jiao Qin Xiang-Cheng Xiao Li-Jian Tao Qiong-Jing Yuan Xin Chen and Li-Min Chen |
| author_facet | Yu Wang Qi-Qi Xing Jing-Ke Tu Wen-Bin Tang Xiang-Ning Yuan Yan-Yun Xie Wei Wang Zhang-Zhe Peng Ling Huang Hui Xu Jiao Qin Xiang-Cheng Xiao Li-Jian Tao Qiong-Jing Yuan Xin Chen and Li-Min Chen |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | Abstract. Objective. Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered endogenous small gas signaling molecule exerting a wide range of biologic actions in our body. This review illustrates recent experimental findings on the mechanisms underlying the therapeutic effects of H2S against renal fibrosis and highlights its potential in future clinical application.
Data sources. Literature was collected from PubMed until February 2019, using the search terms including “Hydrogen sulfide,” “Chronic kidney disease,” “Renal interstitial fibrosis,” “Kidney disease,” “Inflammation factor,” “Oxidative stress,” “Epithelial-to-mesenchymal transition,” “H2S donor,” “Hypertensive kidney dysfunction,” “Myofibroblasts,” “Vascular remodeling,” “transforming growth factor (TGF)-beta/Smads signaling,” and “Sulfate potassium channels.”
Study selection. Literature was mainly derived from English articles or articles that could be obtained with English abstracts. Article type was not limited. References were also identified from the bibliographies of identified articles and the authors’ files.
Results. The experimental data confirmed that H2S is widely involved in various renal pathologies by suppressing inflammation and oxidative stress, inhibiting the activation of fibrosis-related cells and their cytokine expression, ameliorating vascular remodeling and high blood pressure, stimulating tubular cell regeneration, as well as reducing apoptosis, autophagy, and hypertrophy. Therefore, H2S represents an alternative or additional therapeutic approach for renal fibrosis.
Conclusions. We postulate that H2S may delay the occurrence and progress of renal fibrosis, thus protecting renal function. Further experiments are required to explore the precise role of H2S in renal fibrosis and its application in clinical treatment. |
| first_indexed | 2024-12-18T23:13:33Z |
| format | Article |
| id | doaj.art-afd2f6e680904671969b878bf85febdb |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-12-18T23:13:33Z |
| publishDate | 2019-12-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-afd2f6e680904671969b878bf85febdb2022-12-21T20:48:17ZengWolters KluwerChinese Medical Journal0366-69992542-56412019-12-01132232872288010.1097/CM9.0000000000000537201912050-00015Involvement of hydrogen sulfide in the progression of renal fibrosisYu WangQi-Qi XingJing-Ke TuWen-Bin TangXiang-Ning YuanYan-Yun XieWei WangZhang-Zhe PengLing HuangHui XuJiao QinXiang-Cheng XiaoLi-Jian TaoQiong-Jing YuanXin Chen and Li-Min ChenAbstract. Objective. Renal fibrosis is the most common manifestation of chronic kidney disease (CKD). Noting that existing treatments of renal fibrosis only slow disease progression but do not cure it, there is an urgent need to identify novel therapies. Hydrogen sulfide (H2S) is a newly discovered endogenous small gas signaling molecule exerting a wide range of biologic actions in our body. This review illustrates recent experimental findings on the mechanisms underlying the therapeutic effects of H2S against renal fibrosis and highlights its potential in future clinical application. Data sources. Literature was collected from PubMed until February 2019, using the search terms including “Hydrogen sulfide,” “Chronic kidney disease,” “Renal interstitial fibrosis,” “Kidney disease,” “Inflammation factor,” “Oxidative stress,” “Epithelial-to-mesenchymal transition,” “H2S donor,” “Hypertensive kidney dysfunction,” “Myofibroblasts,” “Vascular remodeling,” “transforming growth factor (TGF)-beta/Smads signaling,” and “Sulfate potassium channels.” Study selection. Literature was mainly derived from English articles or articles that could be obtained with English abstracts. Article type was not limited. References were also identified from the bibliographies of identified articles and the authors’ files. Results. The experimental data confirmed that H2S is widely involved in various renal pathologies by suppressing inflammation and oxidative stress, inhibiting the activation of fibrosis-related cells and their cytokine expression, ameliorating vascular remodeling and high blood pressure, stimulating tubular cell regeneration, as well as reducing apoptosis, autophagy, and hypertrophy. Therefore, H2S represents an alternative or additional therapeutic approach for renal fibrosis. Conclusions. We postulate that H2S may delay the occurrence and progress of renal fibrosis, thus protecting renal function. Further experiments are required to explore the precise role of H2S in renal fibrosis and its application in clinical treatment.http://journals.lww.com/10.1097/CM9.0000000000000537 |
| spellingShingle | Yu Wang Qi-Qi Xing Jing-Ke Tu Wen-Bin Tang Xiang-Ning Yuan Yan-Yun Xie Wei Wang Zhang-Zhe Peng Ling Huang Hui Xu Jiao Qin Xiang-Cheng Xiao Li-Jian Tao Qiong-Jing Yuan Xin Chen and Li-Min Chen Involvement of hydrogen sulfide in the progression of renal fibrosis Chinese Medical Journal |
| title | Involvement of hydrogen sulfide in the progression of renal fibrosis |
| title_full | Involvement of hydrogen sulfide in the progression of renal fibrosis |
| title_fullStr | Involvement of hydrogen sulfide in the progression of renal fibrosis |
| title_full_unstemmed | Involvement of hydrogen sulfide in the progression of renal fibrosis |
| title_short | Involvement of hydrogen sulfide in the progression of renal fibrosis |
| title_sort | involvement of hydrogen sulfide in the progression of renal fibrosis |
| url | http://journals.lww.com/10.1097/CM9.0000000000000537 |
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