In vitro and in situ study on characterization and mechanism of the intestinal absorption of 2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside

In vitro and in situ study on characterization and mechanism of the intestinal absorption of 2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside

Abstract Background 2,3,5,4′-tetrahydroxystilbence-2-O-β-D-glucoside (TSG) is a polyhydroxyphenolic compound, which exhibited a broad spectrum of pharmacological activities, such as anti-inflammatory, anti-depression, anti-oxidation and anti-atherosclerosis. However, the compound had poor bioavailab...

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Bibliographic Details
Main Authors: Cheng Wang, Yimeng Zhou, Xiaohong Gong, Li Zheng, Yunxia Li
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Pharmacology and Toxicology
Subjects:
2,3,5,4′-tetrahydroxystilbence-2-O-β-D-glucoside
Absorption mechanism
Caco-2 cell
Intestinal perfusion
P-gp
MRP2
Online Access:https://doi.org/10.1186/s40360-020-0384-9

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