Perivascular adipose tissue in the pathogenesis of cardiovascular disease
Perivascular adipose tissue (PVAT) is an active regulator of vascular homeostasis. In physiological conditions, it maintains normal function of vessels, releasing antiatherogenic, anti-inflammatory and vasodilating biologically active substances. Dysfunctional PVAT secretes pro-inflammatory cytokine...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2021-12-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/4567 |
| _version_ | 1797856632723472384 |
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| author | O. T. Kim V. A. Dadaeva A. I. Korolev O. M. Drapkina |
| author_facet | O. T. Kim V. A. Dadaeva A. I. Korolev O. M. Drapkina |
| author_sort | O. T. Kim |
| collection | DOAJ |
| description | Perivascular adipose tissue (PVAT) is an active regulator of vascular homeostasis. In physiological conditions, it maintains normal function of vessels, releasing antiatherogenic, anti-inflammatory and vasodilating biologically active substances. Dysfunctional PVAT secretes pro-inflammatory cytokines and adipokines, which play an important role in the development of cardiovascular diseases. This review considers the PVAT function in health and disease, its contribution to the pathogenesis of atherosclerosis, hypertension, aortic aneurysm and vasculitis. In addition, novel methods of non-invasive PVAT assessment and potential strategies for targeted treatment of cardiovascular diseases are presented. |
| first_indexed | 2024-04-09T20:44:49Z |
| format | Article |
| id | doaj.art-afd6f2db88424003894e1b58f97600cf |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:44:49Z |
| publishDate | 2021-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-afd6f2db88424003894e1b58f97600cf2023-03-29T21:23:39Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202021-12-01261110.15829/1560-4071-2021-45673334Perivascular adipose tissue in the pathogenesis of cardiovascular diseaseO. T. Kim0V. A. Dadaeva1A. I. Korolev2O. M. Drapkina3National Research Center for Therapy and Preventive MedicineNational Research Center for Therapy and Preventive MedicineNational Research Center for Therapy and Preventive MedicineNational Research Center for Therapy and Preventive MedicinePerivascular adipose tissue (PVAT) is an active regulator of vascular homeostasis. In physiological conditions, it maintains normal function of vessels, releasing antiatherogenic, anti-inflammatory and vasodilating biologically active substances. Dysfunctional PVAT secretes pro-inflammatory cytokines and adipokines, which play an important role in the development of cardiovascular diseases. This review considers the PVAT function in health and disease, its contribution to the pathogenesis of atherosclerosis, hypertension, aortic aneurysm and vasculitis. In addition, novel methods of non-invasive PVAT assessment and potential strategies for targeted treatment of cardiovascular diseases are presented.https://russjcardiol.elpub.ru/jour/article/view/4567perivascular adipose tissueatherosclerosishypertensionaortic aneurysmvasculitischronic inflammation |
| spellingShingle | O. T. Kim V. A. Dadaeva A. I. Korolev O. M. Drapkina Perivascular adipose tissue in the pathogenesis of cardiovascular disease Российский кардиологический журнал perivascular adipose tissue atherosclerosis hypertension aortic aneurysm vasculitis chronic inflammation |
| title | Perivascular adipose tissue in the pathogenesis of cardiovascular disease |
| title_full | Perivascular adipose tissue in the pathogenesis of cardiovascular disease |
| title_fullStr | Perivascular adipose tissue in the pathogenesis of cardiovascular disease |
| title_full_unstemmed | Perivascular adipose tissue in the pathogenesis of cardiovascular disease |
| title_short | Perivascular adipose tissue in the pathogenesis of cardiovascular disease |
| title_sort | perivascular adipose tissue in the pathogenesis of cardiovascular disease |
| topic | perivascular adipose tissue atherosclerosis hypertension aortic aneurysm vasculitis chronic inflammation |
| url | https://russjcardiol.elpub.ru/jour/article/view/4567 |
| work_keys_str_mv | AT otkim perivascularadiposetissueinthepathogenesisofcardiovasculardisease AT vadadaeva perivascularadiposetissueinthepathogenesisofcardiovasculardisease AT aikorolev perivascularadiposetissueinthepathogenesisofcardiovasculardisease AT omdrapkina perivascularadiposetissueinthepathogenesisofcardiovasculardisease |