Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease
The brain's cholinergic arousal pathways decline in parallel with the brain's executive functions in aging and Alzheimer's Disease. The frontline and currently most effective approach to treating Alzheimer's disease is the administration of cholinesterase inhibitors, which, in a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-11-01
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| Series: | Communicative & Integrative Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19420889.2017.1389359 |
| _version_ | 1819182333389963264 |
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| author | David T. Blake Alvin V. Terry Marc Plagenhoef Christos Constantinidis Ruifeng Liu |
| author_facet | David T. Blake Alvin V. Terry Marc Plagenhoef Christos Constantinidis Ruifeng Liu |
| author_sort | David T. Blake |
| collection | DOAJ |
| description | The brain's cholinergic arousal pathways decline in parallel with the brain's executive functions in aging and Alzheimer's Disease. The frontline and currently most effective approach to treating Alzheimer's disease is the administration of cholinesterase inhibitors, which, in a dose dependent manner, improve the symptoms of cognitive decline over the first months of treatment before further decline occurs. We recently showed that intermittent deep brain stimulation of the nucleus basalis of Meynert improves working memory function in young adult monkeys, and that this improvement depended on cholinergic function. Within minutes, the monkeys’ ability to remember stimuli over a delay period improved. Over months, the monkeys performed the working memory task better even in the absence of stimulation. Here, we show historical data from our monkey colony in which more than two dozen animals have performed the same behavioral task to asymptotic performance levels. Using a distribution based on our historical data, we estimate that the monkeys receiving intermittent stimulation leapt over the performance level of 32–44 percent of peer animals in the first several months after stimulation was initiated. Implications for a parallel increase in cognitive function for early Alzheimer's patients are discussed. |
| first_indexed | 2024-12-22T22:44:28Z |
| format | Article |
| id | doaj.art-afd77f36e3e44501890eddfce3375176 |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-12-22T22:44:28Z |
| publishDate | 2017-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-afd77f36e3e44501890eddfce33751762022-12-21T18:10:07ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892017-11-01105-610.1080/19420889.2017.13893591389359Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's diseaseDavid T. Blake0Alvin V. Terry1Marc Plagenhoef2Christos Constantinidis3Ruifeng Liu4Brain and Behavior Discovery InstituteMedical College of Georgia, Augusta UniversityMedical College of Georgia, Augusta UniversityWake Forest School of MedicineState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen UniversityThe brain's cholinergic arousal pathways decline in parallel with the brain's executive functions in aging and Alzheimer's Disease. The frontline and currently most effective approach to treating Alzheimer's disease is the administration of cholinesterase inhibitors, which, in a dose dependent manner, improve the symptoms of cognitive decline over the first months of treatment before further decline occurs. We recently showed that intermittent deep brain stimulation of the nucleus basalis of Meynert improves working memory function in young adult monkeys, and that this improvement depended on cholinergic function. Within minutes, the monkeys’ ability to remember stimuli over a delay period improved. Over months, the monkeys performed the working memory task better even in the absence of stimulation. Here, we show historical data from our monkey colony in which more than two dozen animals have performed the same behavioral task to asymptotic performance levels. Using a distribution based on our historical data, we estimate that the monkeys receiving intermittent stimulation leapt over the performance level of 32–44 percent of peer animals in the first several months after stimulation was initiated. Implications for a parallel increase in cognitive function for early Alzheimer's patients are discussed.http://dx.doi.org/10.1080/19420889.2017.1389359Alzheimer's Diseaseacetylcholinedeep brain stimulation |
| spellingShingle | David T. Blake Alvin V. Terry Marc Plagenhoef Christos Constantinidis Ruifeng Liu Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease Communicative & Integrative Biology Alzheimer's Disease acetylcholine deep brain stimulation |
| title | Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease |
| title_full | Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease |
| title_fullStr | Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease |
| title_full_unstemmed | Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease |
| title_short | Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease |
| title_sort | potential for intermittent stimulation of nucleus basalis of meynert to impact treatment of alzheimer s disease |
| topic | Alzheimer's Disease acetylcholine deep brain stimulation |
| url | http://dx.doi.org/10.1080/19420889.2017.1389359 |
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