Mitochondrial transfer in hematological malignancies
Abstract Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondrial transfer improves mitochondrial defects, restores the biological functions of r...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-10-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-023-00529-x |
| _version_ | 1797451983300329472 |
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| author | Xiaodong Guo Can Can Wancheng Liu Yihong Wei Xinyu Yang Jinting Liu Hexiao Jia Wenbo Jia Hanyang Wu Daoxin Ma |
| author_facet | Xiaodong Guo Can Can Wancheng Liu Yihong Wei Xinyu Yang Jinting Liu Hexiao Jia Wenbo Jia Hanyang Wu Daoxin Ma |
| author_sort | Xiaodong Guo |
| collection | DOAJ |
| description | Abstract Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondrial transfer improves mitochondrial defects, restores the biological functions of recipient cells, and maintains the high metabolic requirements of tumor cells as well as drug resistance. In recent years, it has been reported mitochondrial transfer between cells of bone marrow microenvironment and hematological malignant cells play a critical role in the disease progression and resistance during chemotherapy. In this review, we discuss the patterns and mechanisms on mitochondrial transfer and their engagement in different pathophysiological contexts and outline the latest knowledge on intercellular transport of mitochondria in hematological malignancies. Besides, we briefly outline the drug resistance mechanisms caused by mitochondrial transfer in cells during chemotherapy. Our review demonstrates a theoretical basis for mitochondrial transfer as a prospective therapeutic target to increase the treatment efficiency in hematological malignancies and improve the prognosis of patients. |
| first_indexed | 2024-03-09T15:02:17Z |
| format | Article |
| id | doaj.art-afd8829e317f445e87aad5e31536ccb8 |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-03-09T15:02:17Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-afd8829e317f445e87aad5e31536ccb82023-11-26T13:52:35ZengBMCBiomarker Research2050-77712023-10-0111111610.1186/s40364-023-00529-xMitochondrial transfer in hematological malignanciesXiaodong Guo0Can Can1Wancheng Liu2Yihong Wei3Xinyu Yang4Jinting Liu5Hexiao Jia6Wenbo Jia7Hanyang Wu8Daoxin Ma9Department of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityDepartment of Hematology, Qilu Hospital of Shandong UniversityAbstract Mitochondria are energy-generated organelles and take an important part in biological metabolism. Mitochondria could be transferred between cells, which serves as a new intercellular communication. Mitochondrial transfer improves mitochondrial defects, restores the biological functions of recipient cells, and maintains the high metabolic requirements of tumor cells as well as drug resistance. In recent years, it has been reported mitochondrial transfer between cells of bone marrow microenvironment and hematological malignant cells play a critical role in the disease progression and resistance during chemotherapy. In this review, we discuss the patterns and mechanisms on mitochondrial transfer and their engagement in different pathophysiological contexts and outline the latest knowledge on intercellular transport of mitochondria in hematological malignancies. Besides, we briefly outline the drug resistance mechanisms caused by mitochondrial transfer in cells during chemotherapy. Our review demonstrates a theoretical basis for mitochondrial transfer as a prospective therapeutic target to increase the treatment efficiency in hematological malignancies and improve the prognosis of patients.https://doi.org/10.1186/s40364-023-00529-xMitochondrial transferTunneling nanotubesExtracellular vesiclesExtracellular mitochondriaHematological malignancies |
| spellingShingle | Xiaodong Guo Can Can Wancheng Liu Yihong Wei Xinyu Yang Jinting Liu Hexiao Jia Wenbo Jia Hanyang Wu Daoxin Ma Mitochondrial transfer in hematological malignancies Biomarker Research Mitochondrial transfer Tunneling nanotubes Extracellular vesicles Extracellular mitochondria Hematological malignancies |
| title | Mitochondrial transfer in hematological malignancies |
| title_full | Mitochondrial transfer in hematological malignancies |
| title_fullStr | Mitochondrial transfer in hematological malignancies |
| title_full_unstemmed | Mitochondrial transfer in hematological malignancies |
| title_short | Mitochondrial transfer in hematological malignancies |
| title_sort | mitochondrial transfer in hematological malignancies |
| topic | Mitochondrial transfer Tunneling nanotubes Extracellular vesicles Extracellular mitochondria Hematological malignancies |
| url | https://doi.org/10.1186/s40364-023-00529-x |
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