Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review
Focal active colitis (FAC) is described as a histolopathological term indicating the isolated finding of focal neutrophil infiltration in the colonic crypts. Currently, there exist numerous debates regarding the clinical significance of diagnosing FAC, which may or may not have clinical relevance as...
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| Aineistotyyppi: | Artikkeli |
| Kieli: | English |
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MDPI AG
2023-09-01
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| Sarja: | Biomedicines |
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| Linkit: | https://www.mdpi.com/2227-9059/11/10/2631 |
| _version_ | 1827721629280501760 |
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| author | Emanuele Sinagra Francesco Vito Mandarino Marcello Maida Daniela Cabibi Francesca Rossi Dario Raimondo Guido Manfredi |
| author_facet | Emanuele Sinagra Francesco Vito Mandarino Marcello Maida Daniela Cabibi Francesca Rossi Dario Raimondo Guido Manfredi |
| author_sort | Emanuele Sinagra |
| collection | DOAJ |
| description | Focal active colitis (FAC) is described as a histolopathological term indicating the isolated finding of focal neutrophil infiltration in the colonic crypts. Currently, there exist numerous debates regarding the clinical significance of diagnosing FAC, which may or may not have clinical relevance as it is frequently detected in colorectal biopsies without any other microscopic abnormalities. The objective of this narrative review is to provide an overview of the available evidence concerning the clinical implications of FAC, both in the adult population (among five studies available in the scientific literature) and in the pediatric context (based on two available studies). |
| first_indexed | 2024-03-10T21:25:45Z |
| format | Article |
| id | doaj.art-afdab648f3564ee5af6130299444080b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T21:25:45Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-afdab648f3564ee5af6130299444080b2023-11-19T15:44:50ZengMDPI AGBiomedicines2227-90592023-09-011110263110.3390/biomedicines11102631Focal Active Colitis: What Are Its Clinical Implications? A Narrative ReviewEmanuele Sinagra0Francesco Vito Mandarino1Marcello Maida2Daniela Cabibi3Francesca Rossi4Dario Raimondo5Guido Manfredi6Gastroenterology and Endoscopy Unit, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, ItalyDivision of Gastroenterology and Gastrointestinal Endoscopy, Department of Experimental Oncology, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, 20132 Milan, ItalyGastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, 93100 Caltanissetta, ItalyPathology Unit, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, ItalyGastroenterology and Endoscopy Unit, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, ItalyGastroenterology and Endoscopy Unit, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, ItalyGastroenterology and Digestive Endoscopy Department, ASST-Crema Maggiore Hospital, 26013 Crema, ItalyFocal active colitis (FAC) is described as a histolopathological term indicating the isolated finding of focal neutrophil infiltration in the colonic crypts. Currently, there exist numerous debates regarding the clinical significance of diagnosing FAC, which may or may not have clinical relevance as it is frequently detected in colorectal biopsies without any other microscopic abnormalities. The objective of this narrative review is to provide an overview of the available evidence concerning the clinical implications of FAC, both in the adult population (among five studies available in the scientific literature) and in the pediatric context (based on two available studies).https://www.mdpi.com/2227-9059/11/10/2631focal active colitisCrohn’s diseaseulcerative colitisself-limiting colitisindeterminate colitis |
| spellingShingle | Emanuele Sinagra Francesco Vito Mandarino Marcello Maida Daniela Cabibi Francesca Rossi Dario Raimondo Guido Manfredi Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review Biomedicines focal active colitis Crohn’s disease ulcerative colitis self-limiting colitis indeterminate colitis |
| title | Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review |
| title_full | Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review |
| title_fullStr | Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review |
| title_full_unstemmed | Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review |
| title_short | Focal Active Colitis: What Are Its Clinical Implications? A Narrative Review |
| title_sort | focal active colitis what are its clinical implications a narrative review |
| topic | focal active colitis Crohn’s disease ulcerative colitis self-limiting colitis indeterminate colitis |
| url | https://www.mdpi.com/2227-9059/11/10/2631 |
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