Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans
Abstract Normal blood [glucose] regulation is critical to support metabolism, particularly in contexts of metabolic stressors (e.g., exercise, high altitude hypoxia). Data regarding blood [glucose] regulation in hypoxia are inconclusive. We aimed to characterize blood [glucose] over 80 min following...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.14932 |
| _version_ | 1818722612584382464 |
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| author | Jason S. Chan Alexandra E. Chiew Alexander N. Rimke Garrick Chan Zahrah H. Rampuri Mackenzie D. Kozak Normand G. Boulé Craig D. Steinback Margie H. Davenport Trevor A. Day |
| author_facet | Jason S. Chan Alexandra E. Chiew Alexander N. Rimke Garrick Chan Zahrah H. Rampuri Mackenzie D. Kozak Normand G. Boulé Craig D. Steinback Margie H. Davenport Trevor A. Day |
| author_sort | Jason S. Chan |
| collection | DOAJ |
| description | Abstract Normal blood [glucose] regulation is critical to support metabolism, particularly in contexts of metabolic stressors (e.g., exercise, high altitude hypoxia). Data regarding blood [glucose] regulation in hypoxia are inconclusive. We aimed to characterize blood [glucose] over 80 min following glucose ingestion during both normoxia and acute normobaric hypoxia. In a randomized cross‐over design, on two separate days, 28 healthy participants (16 females; 21.8 ± 1.6 years; BMI 22.8 ± 2.5 kg/m2) were randomly exposed to either NX (room air; fraction of inspired [FI]O2 ~0.21) or HX (FIO2 ~0.148) in a normobaric hypoxia chamber. Measured FIO2 and peripheral oxygen saturation were both lower at baseline in hypoxia (p < 0.001), which was maintained over 80 min, confirming the hypoxic intervention. Following a 10‐min baseline (BL) under both conditions, participants consumed a standardized glucose beverage (75 g, 296 ml) and blood [glucose] and physiological variables were measured at BL intermittently over 80 min. Blood [glucose] was measured from finger capillary samples via glucometer. Initial fasted blood [glucose] was not different between trials (NX:4.8 ± 0.4 vs. HX:4.9 ± 0.4 mmol/L; p = 0.47). Blood [glucose] was sampled every 10 min (absolute, delta, and percent change) following glucose ingestion over 80 min, and was not different between conditions (p > 0.77). In addition, mean, peak, and time‐to‐peak responses during the 80 min were not different between conditions (p > 0.14). There were also no sex differences in these blood [glucose] responses in hypoxia. We conclude that glucose regulation is unchanged in young, healthy participants with exposure to acute steady‐state normobaric hypoxia, likely due to counterbalancing mechanisms underlying blood [glucose] regulation in hypoxia. |
| first_indexed | 2024-12-17T20:57:24Z |
| format | Article |
| id | doaj.art-afdbd931606e4292acfafcc6cb036d54 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-17T20:57:24Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
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| series | Physiological Reports |
| spelling | doaj.art-afdbd931606e4292acfafcc6cb036d542022-12-21T21:32:50ZengWileyPhysiological Reports2051-817X2021-08-01915n/an/a10.14814/phy2.14932Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humansJason S. Chan0Alexandra E. Chiew1Alexander N. Rimke2Garrick Chan3Zahrah H. Rampuri4Mackenzie D. Kozak5Normand G. Boulé6Craig D. Steinback7Margie H. Davenport8Trevor A. Day9Department of Biology Faculty of Science and Technology Mount Royal University Calgary AB CanadaDepartment of Biology Faculty of Science and Technology Mount Royal University Calgary AB CanadaDepartment of Biology Faculty of Science and Technology Mount Royal University Calgary AB CanadaDepartment of Biology Faculty of Science and Technology Mount Royal University Calgary AB CanadaDepartment of Biology Faculty of Science and Technology Mount Royal University Calgary AB CanadaDepartment of Biology Faculty of Science and Technology Mount Royal University Calgary AB CanadaAlberta Diabetes Institute Faculty of Kinesiology, Sport, and Recreation University of Alberta Edmonton AB CanadaAlberta Diabetes Institute Faculty of Kinesiology, Sport, and Recreation University of Alberta Edmonton AB CanadaAlberta Diabetes Institute Faculty of Kinesiology, Sport, and Recreation University of Alberta Edmonton AB CanadaDepartment of Biology Faculty of Science and Technology Mount Royal University Calgary AB CanadaAbstract Normal blood [glucose] regulation is critical to support metabolism, particularly in contexts of metabolic stressors (e.g., exercise, high altitude hypoxia). Data regarding blood [glucose] regulation in hypoxia are inconclusive. We aimed to characterize blood [glucose] over 80 min following glucose ingestion during both normoxia and acute normobaric hypoxia. In a randomized cross‐over design, on two separate days, 28 healthy participants (16 females; 21.8 ± 1.6 years; BMI 22.8 ± 2.5 kg/m2) were randomly exposed to either NX (room air; fraction of inspired [FI]O2 ~0.21) or HX (FIO2 ~0.148) in a normobaric hypoxia chamber. Measured FIO2 and peripheral oxygen saturation were both lower at baseline in hypoxia (p < 0.001), which was maintained over 80 min, confirming the hypoxic intervention. Following a 10‐min baseline (BL) under both conditions, participants consumed a standardized glucose beverage (75 g, 296 ml) and blood [glucose] and physiological variables were measured at BL intermittently over 80 min. Blood [glucose] was measured from finger capillary samples via glucometer. Initial fasted blood [glucose] was not different between trials (NX:4.8 ± 0.4 vs. HX:4.9 ± 0.4 mmol/L; p = 0.47). Blood [glucose] was sampled every 10 min (absolute, delta, and percent change) following glucose ingestion over 80 min, and was not different between conditions (p > 0.77). In addition, mean, peak, and time‐to‐peak responses during the 80 min were not different between conditions (p > 0.14). There were also no sex differences in these blood [glucose] responses in hypoxia. We conclude that glucose regulation is unchanged in young, healthy participants with exposure to acute steady‐state normobaric hypoxia, likely due to counterbalancing mechanisms underlying blood [glucose] regulation in hypoxia.https://doi.org/10.14814/phy2.14932acute hyperglycemiaacute hypoxiablood [glucose] regulationinsulin sensitivity |
| spellingShingle | Jason S. Chan Alexandra E. Chiew Alexander N. Rimke Garrick Chan Zahrah H. Rampuri Mackenzie D. Kozak Normand G. Boulé Craig D. Steinback Margie H. Davenport Trevor A. Day Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans Physiological Reports acute hyperglycemia acute hypoxia blood [glucose] regulation insulin sensitivity |
| title | Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans |
| title_full | Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans |
| title_fullStr | Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans |
| title_full_unstemmed | Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans |
| title_short | Blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans |
| title_sort | blood glucose concentration is unchanged during exposure to acute normobaric hypoxia in healthy humans |
| topic | acute hyperglycemia acute hypoxia blood [glucose] regulation insulin sensitivity |
| url | https://doi.org/10.14814/phy2.14932 |
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