Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats
Introduction: Pathogenic role of free radicals are well known in various metabolic diseases. They originate from internal and external sources of body. Essential roles of antioxidant defense system for cellular redox regulation and free radical scavenging activity were described in this study. Many...
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| Format: | Article |
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Tabriz University of Medical Sciences
2012-07-01
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| Series: | BioImpacts |
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| Online Access: | http://dx.doi.org/10.5681/bi.2012.020 |
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| author | Adel Rezaei-Moghadam Daryoush Mohajeri Behnam Rafiei Rana Dizaji Asghar Azhdari Mahdi Yeganehzad Maryamossadat Shahidi Mohammad Mazani |
| author_facet | Adel Rezaei-Moghadam Daryoush Mohajeri Behnam Rafiei Rana Dizaji Asghar Azhdari Mahdi Yeganehzad Maryamossadat Shahidi Mohammad Mazani |
| author_sort | Adel Rezaei-Moghadam |
| collection | DOAJ |
| description | Introduction: Pathogenic role of free radicals are well known in various metabolic diseases. They originate from internal and external sources of body. Essential roles of antioxidant defense system for cellular redox regulation and free radical scavenging activity were described in this study. Many in vitro investigations have shown that turmeric (TE) and carrot seed extract (CSE) exhibits to possess antioxidant activities. In this study, we evaluated the antioxidant potentials of ethanolic TE and CSE based on in vivo experiment in the rats. Methods: Animals were assigned to six groups: the 1st and 2nd groups were control groups and 2nd group received 0.2 ml dimethyl sulphoxide as vehicle treated group; other four experimental groups received different doses of TE (100, 200 mg/kg b.w.) and CSE (200, 400 mg/kg b.w.) by gavages, respectively for a period of one month. The indicators of oxidative stress, lipids peroxidation, markers of hepatocyte injury and biliary function markers were measured. Results: The levels of superoxide dismutase, catalase, and glutathione peroxidase were significantly stimulated in the hepatic tissue of treatment groups. The malondialdehyde contents of liver tissue were significantly reduced in the groups fed with TE and CSE. Serum levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase, in treated groups were found to be significantly decreased, whereas albumin and total protein increased as compared to the control groups (P<0.05). Conclusion: this study showed that the regular intake of TE and CSE through the diet can improve antioxidant status and inhibit peroxidation activity in the liver tissue so that using these extracts may protect tissue oxidative stress. |
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| language | English |
| last_indexed | 2024-12-12T06:00:07Z |
| publishDate | 2012-07-01 |
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| record_format | Article |
| series | BioImpacts |
| spelling | doaj.art-afdbe1782b9c47d8a23943dee5c140e32022-12-22T00:35:26ZengTabriz University of Medical SciencesBioImpacts2228-56522228-56602012-07-0123151157Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in RatsAdel Rezaei-MoghadamDaryoush MohajeriBehnam RafieiRana DizajiAsghar AzhdariMahdi YeganehzadMaryamossadat ShahidiMohammad MazaniIntroduction: Pathogenic role of free radicals are well known in various metabolic diseases. They originate from internal and external sources of body. Essential roles of antioxidant defense system for cellular redox regulation and free radical scavenging activity were described in this study. Many in vitro investigations have shown that turmeric (TE) and carrot seed extract (CSE) exhibits to possess antioxidant activities. In this study, we evaluated the antioxidant potentials of ethanolic TE and CSE based on in vivo experiment in the rats. Methods: Animals were assigned to six groups: the 1st and 2nd groups were control groups and 2nd group received 0.2 ml dimethyl sulphoxide as vehicle treated group; other four experimental groups received different doses of TE (100, 200 mg/kg b.w.) and CSE (200, 400 mg/kg b.w.) by gavages, respectively for a period of one month. The indicators of oxidative stress, lipids peroxidation, markers of hepatocyte injury and biliary function markers were measured. Results: The levels of superoxide dismutase, catalase, and glutathione peroxidase were significantly stimulated in the hepatic tissue of treatment groups. The malondialdehyde contents of liver tissue were significantly reduced in the groups fed with TE and CSE. Serum levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase, in treated groups were found to be significantly decreased, whereas albumin and total protein increased as compared to the control groups (P<0.05). Conclusion: this study showed that the regular intake of TE and CSE through the diet can improve antioxidant status and inhibit peroxidation activity in the liver tissue so that using these extracts may protect tissue oxidative stress.http://dx.doi.org/10.5681/bi.2012.020Turmeric ExtractCarrot Seed ExtractTotal Antioxidant StatusLipid PeroxidationAntioxidant EnzymesSerum Liver Biomarkers |
| spellingShingle | Adel Rezaei-Moghadam Daryoush Mohajeri Behnam Rafiei Rana Dizaji Asghar Azhdari Mahdi Yeganehzad Maryamossadat Shahidi Mohammad Mazani Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats BioImpacts Turmeric Extract Carrot Seed Extract Total Antioxidant Status Lipid Peroxidation Antioxidant Enzymes Serum Liver Biomarkers |
| title | Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats |
| title_full | Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats |
| title_fullStr | Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats |
| title_full_unstemmed | Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats |
| title_short | Effect of Turmeric and Carrot Seed Extracts on Serum Liver Biomarkers and Hepatic Lipid Peroxidation, Antioxidant Enzymes and Total Antioxidant Status in Rats |
| title_sort | effect of turmeric and carrot seed extracts on serum liver biomarkers and hepatic lipid peroxidation antioxidant enzymes and total antioxidant status in rats |
| topic | Turmeric Extract Carrot Seed Extract Total Antioxidant Status Lipid Peroxidation Antioxidant Enzymes Serum Liver Biomarkers |
| url | http://dx.doi.org/10.5681/bi.2012.020 |
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