Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia
Objectives Muscle soreness occurs after exercise and also in musculoskeletal diseases, such as fibromyalgia (FM). However, the nosography and pathoetiology of morbid soreness in FM remain unknown. This study aimed to investigate the morbid soreness of FM, evaluate its therapeutic responses and probe...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-03-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/9/1/e002741.full |
| _version_ | 1797867476553302016 |
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| author | Fu-Wen Liang Chih-Hsien Hung Cheng-Han Lee Ming-Hsien Tsai Chung-Yao Hsu Chiou-Lian Lai Chih-Cheng Chen Der-Sheng Han Po-Sheng Wang Kuo-Wei Lee Yi-On Fong |
| author_facet | Fu-Wen Liang Chih-Hsien Hung Cheng-Han Lee Ming-Hsien Tsai Chung-Yao Hsu Chiou-Lian Lai Chih-Cheng Chen Der-Sheng Han Po-Sheng Wang Kuo-Wei Lee Yi-On Fong |
| author_sort | Fu-Wen Liang |
| collection | DOAJ |
| description | Objectives Muscle soreness occurs after exercise and also in musculoskeletal diseases, such as fibromyalgia (FM). However, the nosography and pathoetiology of morbid soreness in FM remain unknown. This study aimed to investigate the morbid soreness of FM, evaluate its therapeutic responses and probe its pathophysiology with metabolomics profiling.Methods Patients with newly diagnosed FM were prospectively recruited and completed self-report questionnaires pertaining to musculoskeletal symptoms. The phenotypes and metabotypes were assessed with variance, classification and correlation analyses.Results Fifty-one patients and 41 healthy controls were included. Soreness symptoms were prevalent in FM individuals (92.2%). In terms of manifestations and metabolomic features, phenotypes diverged between patients with mixed pain and soreness symptoms (FM-PS) and those with pain dominant symptoms. Conventional treatment for FM did not ameliorate soreness severity despite its efficacy on pain. Moreover, despite the salient therapeutic efficacy on pain relief in FM-PS cases, conventional treatment did not improve their general disease severity. Metabolomics analyses suggested oxidative metabolism dysregulation in FM, and high malondialdehyde level indicated excessive oxidative stress in FM individuals as compared with controls (p=0.009). Contrary to exercise-induced soreness, lactate levels were significantly lower in FM individuals than controls, especially in FM-PS. Moreover, FM-PS cases exclusively featured increased malondialdehyde level (p=0.008) and a correlative trend between malondialdehyde expression and soreness intensity (r=0.337, p=0.086).Conclusions Morbid soreness symptoms were prevalent in FM, with the presentation and therapeutic responses different from FM pain conditions. Oxidative stress rather than lactate accumulation involved phenotype modulation of the morbid soreness in FM.Trial registration number NCT04832100. |
| first_indexed | 2024-04-09T23:41:53Z |
| format | Article |
| id | doaj.art-afdc149684364573b3328b71ddc95de9 |
| institution | Directory Open Access Journal |
| issn | 2056-5933 |
| language | English |
| last_indexed | 2024-04-09T23:41:53Z |
| publishDate | 2023-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj.art-afdc149684364573b3328b71ddc95de92023-03-18T17:30:06ZengBMJ Publishing GroupRMD Open2056-59332023-03-019110.1136/rmdopen-2022-002741Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgiaFu-Wen Liang0Chih-Hsien Hung1Cheng-Han Lee2Ming-Hsien Tsai3Chung-Yao Hsu4Chiou-Lian Lai5Chih-Cheng Chen6Der-Sheng Han7Po-Sheng Wang8Kuo-Wei Lee9Yi-On Fong10Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanInstitute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanDepartment of Child Care, National Pingtung University of Science and Technology, Pingtung, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanInstitute of Biomedical Sciences, Academia Sinica, Taipei, TaiwanDepartment of Physical Medicine and Rehabilitation, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Nutrition and Health Sciences, Fooyin University, Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanObjectives Muscle soreness occurs after exercise and also in musculoskeletal diseases, such as fibromyalgia (FM). However, the nosography and pathoetiology of morbid soreness in FM remain unknown. This study aimed to investigate the morbid soreness of FM, evaluate its therapeutic responses and probe its pathophysiology with metabolomics profiling.Methods Patients with newly diagnosed FM were prospectively recruited and completed self-report questionnaires pertaining to musculoskeletal symptoms. The phenotypes and metabotypes were assessed with variance, classification and correlation analyses.Results Fifty-one patients and 41 healthy controls were included. Soreness symptoms were prevalent in FM individuals (92.2%). In terms of manifestations and metabolomic features, phenotypes diverged between patients with mixed pain and soreness symptoms (FM-PS) and those with pain dominant symptoms. Conventional treatment for FM did not ameliorate soreness severity despite its efficacy on pain. Moreover, despite the salient therapeutic efficacy on pain relief in FM-PS cases, conventional treatment did not improve their general disease severity. Metabolomics analyses suggested oxidative metabolism dysregulation in FM, and high malondialdehyde level indicated excessive oxidative stress in FM individuals as compared with controls (p=0.009). Contrary to exercise-induced soreness, lactate levels were significantly lower in FM individuals than controls, especially in FM-PS. Moreover, FM-PS cases exclusively featured increased malondialdehyde level (p=0.008) and a correlative trend between malondialdehyde expression and soreness intensity (r=0.337, p=0.086).Conclusions Morbid soreness symptoms were prevalent in FM, with the presentation and therapeutic responses different from FM pain conditions. Oxidative stress rather than lactate accumulation involved phenotype modulation of the morbid soreness in FM.Trial registration number NCT04832100.https://rmdopen.bmj.com/content/9/1/e002741.full |
| spellingShingle | Fu-Wen Liang Chih-Hsien Hung Cheng-Han Lee Ming-Hsien Tsai Chung-Yao Hsu Chiou-Lian Lai Chih-Cheng Chen Der-Sheng Han Po-Sheng Wang Kuo-Wei Lee Yi-On Fong Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia RMD Open |
| title | Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia |
| title_full | Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia |
| title_fullStr | Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia |
| title_full_unstemmed | Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia |
| title_short | Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia |
| title_sort | oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia |
| url | https://rmdopen.bmj.com/content/9/1/e002741.full |
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