Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI)
Magnetic resonance imaging (MRI) is a useful tool for disease diagnosis and treatment monitoring. Superparamagnetic iron oxide nanoparticles (SPION) show good performance as transverse relaxation (T<sub>2</sub>) contrast agents, thus facilitating the interpretation of the acquired images...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/9/10/1364 |
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| author | Marina Llenas Stefania Sandoval Pedro M. Costa Judith Oró-Solé Silvia Lope-Piedrafita Belén Ballesteros Khuloud T. Al-Jamal Gerard Tobias |
| author_facet | Marina Llenas Stefania Sandoval Pedro M. Costa Judith Oró-Solé Silvia Lope-Piedrafita Belén Ballesteros Khuloud T. Al-Jamal Gerard Tobias |
| author_sort | Marina Llenas |
| collection | DOAJ |
| description | Magnetic resonance imaging (MRI) is a useful tool for disease diagnosis and treatment monitoring. Superparamagnetic iron oxide nanoparticles (SPION) show good performance as transverse relaxation (T<sub>2</sub>) contrast agents, thus facilitating the interpretation of the acquired images. Attachment of SPION onto nanocarriers prevents their agglomeration, improving the circulation time and efficiency. Graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (RGO), are appealing nanocarriers since they have both high surface area and functional moieties that make them ideal substrates for the attachment of nanoparticles. We have employed a fast, simple and environmentally friendly microwave-assisted approach for the synthesis of SPION-RGO hybrids. Different iron precursor/GO ratios were used leading to SPION, with a median diameter of 7.1 nm, homogeneously distributed along the RGO surface. Good relaxivity (r<sub>2</sub>*) values were obtained in MRI studies and no significant toxicity was detected within in vitro tests following GL261 glioma and J774 macrophage-like cells for 24 h with SPION-RGO, demonstrating the applicability of the hybrids as T<sub>2</sub>-weighted MRI contrast agents. |
| first_indexed | 2024-12-11T00:17:12Z |
| format | Article |
| id | doaj.art-afddcaa881b54f4e8888389a3cddad7d |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-11T00:17:12Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-afddcaa881b54f4e8888389a3cddad7d2022-12-22T01:27:54ZengMDPI AGNanomaterials2079-49912019-09-01910136410.3390/nano9101364nano9101364Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI)Marina Llenas0Stefania Sandoval1Pedro M. Costa2Judith Oró-Solé3Silvia Lope-Piedrafita4Belén Ballesteros5Khuloud T. Al-Jamal6Gerard Tobias7Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus de la UAB, 08193 Bellaterra (Barcelona), SpainInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus de la UAB, 08193 Bellaterra (Barcelona), SpainInstitute of Pharmaceutical Science, King’s College London, London SE1 9NH, UKInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus de la UAB, 08193 Bellaterra (Barcelona), SpainServei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, Campus UAB, 08193 Bellaterra (Barcelona), SpainCatalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and the Barcelona Institute of Science and Technology, Campus UAB, 08193 Bellaterra (Barcelona), SpainInstitute of Pharmaceutical Science, King’s College London, London SE1 9NH, UKInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus de la UAB, 08193 Bellaterra (Barcelona), SpainMagnetic resonance imaging (MRI) is a useful tool for disease diagnosis and treatment monitoring. Superparamagnetic iron oxide nanoparticles (SPION) show good performance as transverse relaxation (T<sub>2</sub>) contrast agents, thus facilitating the interpretation of the acquired images. Attachment of SPION onto nanocarriers prevents their agglomeration, improving the circulation time and efficiency. Graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (RGO), are appealing nanocarriers since they have both high surface area and functional moieties that make them ideal substrates for the attachment of nanoparticles. We have employed a fast, simple and environmentally friendly microwave-assisted approach for the synthesis of SPION-RGO hybrids. Different iron precursor/GO ratios were used leading to SPION, with a median diameter of 7.1 nm, homogeneously distributed along the RGO surface. Good relaxivity (r<sub>2</sub>*) values were obtained in MRI studies and no significant toxicity was detected within in vitro tests following GL261 glioma and J774 macrophage-like cells for 24 h with SPION-RGO, demonstrating the applicability of the hybrids as T<sub>2</sub>-weighted MRI contrast agents.https://www.mdpi.com/2079-4991/9/10/1364contrast agentsbiomedical imagingultrasmall superparamagnetic iron oxide nanoparticles |
| spellingShingle | Marina Llenas Stefania Sandoval Pedro M. Costa Judith Oró-Solé Silvia Lope-Piedrafita Belén Ballesteros Khuloud T. Al-Jamal Gerard Tobias Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI) Nanomaterials contrast agents biomedical imaging ultrasmall superparamagnetic iron oxide nanoparticles |
| title | Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI) |
| title_full | Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI) |
| title_fullStr | Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI) |
| title_full_unstemmed | Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI) |
| title_short | Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI) |
| title_sort | microwave assisted synthesis of spion reduced graphene oxide hybrids for magnetic resonance imaging mri |
| topic | contrast agents biomedical imaging ultrasmall superparamagnetic iron oxide nanoparticles |
| url | https://www.mdpi.com/2079-4991/9/10/1364 |
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