The Definitive Diagnosis of Tuberculous Meningitis (TBM) di RSUP dr. Kariadi Semarang Descriptive study in adult patients using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis
Tuberculous meningitis (TBM) is the most common cause of central nervous system infection and has very high morbidity and mortality. The definitive diagnosis of TBM in RSUP dr Kariadi Semarang has been insufficient. This study aimed at finding out the definitive diagnosis of TBM di RSUP dr Kariadi S...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Sultan Agung Semarang
2013-12-01
|
| Series: | Sains Medika |
| Subjects: | |
| Online Access: | http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/343 |
| _version_ | 1811314628289888256 |
|---|---|
| author | Masfiyah Masfiyah Aris Catur Bintoro Purnomo Hadi |
| author_facet | Masfiyah Masfiyah Aris Catur Bintoro Purnomo Hadi |
| author_sort | Masfiyah Masfiyah |
| collection | DOAJ |
| description | Tuberculous meningitis (TBM) is the most common cause of central nervous system infection and has very high morbidity and mortality. The definitive diagnosis of TBM in RSUP dr Kariadi Semarang has been insufficient. This study aimed at finding out the definitive diagnosis of TBM di RSUP dr Kariadi Semarang using IS6110 sensitive and specific primer. This was a descriptive study included all in-patients with meningitis and/or TBM of RSUP Dr Kariadi Semarang aged > 14 years with Thwaites’ Diagnostic Score ≤ 4 between March 1, 2013 and November, 30 2013. The devinitive diagnosis of TBM was made using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis complex conducted in microbiology clinic of FK UNDIP/RSUP dr. Kariadi Semarang. The secondary data was the basic and laboratory data from the medical records of the patients. Mean age was 39.59 ± 15.7. Six (35.3%) pasients were diagnosed with devinitive TBM, 3 (17.64%) were meningitis positive by NTM (Non Tuberculous Mycobacteria). Dual infection was found in 1 (5.8%) case between TBM and bacterial meningitis. Most patients were productive age. Some had devititive TBM. The pasient with meningitis and dual infection were also diagnosed with NTM (Non Tuberculous Mycobacteria). |
| first_indexed | 2024-04-13T11:14:42Z |
| format | Article |
| id | doaj.art-afdef5d07d5b4264baa20016a501d1a9 |
| institution | Directory Open Access Journal |
| issn | 2085-1545 2339-093X |
| language | English |
| last_indexed | 2024-04-13T11:14:42Z |
| publishDate | 2013-12-01 |
| publisher | Universitas Sultan Agung Semarang |
| record_format | Article |
| series | Sains Medika |
| spelling | doaj.art-afdef5d07d5b4264baa20016a501d1a92022-12-22T02:49:01ZengUniversitas Sultan Agung SemarangSains Medika2085-15452339-093X2013-12-0152626710.26532/sainsmed.v5i2.343339The Definitive Diagnosis of Tuberculous Meningitis (TBM) di RSUP dr. Kariadi Semarang Descriptive study in adult patients using IS6110-based PCR amplification for detecting Mycobacterium tuberculosisMasfiyah Masfiyah0Aris Catur Bintoro1Purnomo Hadi2Staf Bagian Mikrobiologi Klinik FK UNISSULA SemarangStaf Bagian Neurologi Fakultas Kedokteran Universitas Diponegoro/RSUP dr. Kariadi SemarangStaf Bagian Mikrobiologi Klinik Fakultas Kedokteran Universitas Diponegoro/RSUP dr. Kariadi SemarangTuberculous meningitis (TBM) is the most common cause of central nervous system infection and has very high morbidity and mortality. The definitive diagnosis of TBM in RSUP dr Kariadi Semarang has been insufficient. This study aimed at finding out the definitive diagnosis of TBM di RSUP dr Kariadi Semarang using IS6110 sensitive and specific primer. This was a descriptive study included all in-patients with meningitis and/or TBM of RSUP Dr Kariadi Semarang aged > 14 years with Thwaites’ Diagnostic Score ≤ 4 between March 1, 2013 and November, 30 2013. The devinitive diagnosis of TBM was made using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis complex conducted in microbiology clinic of FK UNDIP/RSUP dr. Kariadi Semarang. The secondary data was the basic and laboratory data from the medical records of the patients. Mean age was 39.59 ± 15.7. Six (35.3%) pasients were diagnosed with devinitive TBM, 3 (17.64%) were meningitis positive by NTM (Non Tuberculous Mycobacteria). Dual infection was found in 1 (5.8%) case between TBM and bacterial meningitis. Most patients were productive age. Some had devititive TBM. The pasient with meningitis and dual infection were also diagnosed with NTM (Non Tuberculous Mycobacteria).http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/343adultmeningitis TBPCRRSUP dr Kariadi Semarang |
| spellingShingle | Masfiyah Masfiyah Aris Catur Bintoro Purnomo Hadi The Definitive Diagnosis of Tuberculous Meningitis (TBM) di RSUP dr. Kariadi Semarang Descriptive study in adult patients using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis Sains Medika adult meningitis TB PCR RSUP dr Kariadi Semarang |
| title | The Definitive Diagnosis of Tuberculous Meningitis (TBM) di RSUP dr. Kariadi Semarang Descriptive study in adult patients using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis |
| title_full | The Definitive Diagnosis of Tuberculous Meningitis (TBM) di RSUP dr. Kariadi Semarang Descriptive study in adult patients using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis |
| title_fullStr | The Definitive Diagnosis of Tuberculous Meningitis (TBM) di RSUP dr. Kariadi Semarang Descriptive study in adult patients using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis |
| title_full_unstemmed | The Definitive Diagnosis of Tuberculous Meningitis (TBM) di RSUP dr. Kariadi Semarang Descriptive study in adult patients using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis |
| title_short | The Definitive Diagnosis of Tuberculous Meningitis (TBM) di RSUP dr. Kariadi Semarang Descriptive study in adult patients using IS6110-based PCR amplification for detecting Mycobacterium tuberculosis |
| title_sort | definitive diagnosis of tuberculous meningitis tbm di rsup dr kariadi semarang descriptive study in adult patients using is6110 based pcr amplification for detecting mycobacterium tuberculosis |
| topic | adult meningitis TB PCR RSUP dr Kariadi Semarang |
| url | http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/343 |
| work_keys_str_mv | AT masfiyahmasfiyah thedefinitivediagnosisoftuberculousmeningitistbmdirsupdrkariadisemarangdescriptivestudyinadultpatientsusingis6110basedpcramplificationfordetectingmycobacteriumtuberculosis AT ariscaturbintoro thedefinitivediagnosisoftuberculousmeningitistbmdirsupdrkariadisemarangdescriptivestudyinadultpatientsusingis6110basedpcramplificationfordetectingmycobacteriumtuberculosis AT purnomohadi thedefinitivediagnosisoftuberculousmeningitistbmdirsupdrkariadisemarangdescriptivestudyinadultpatientsusingis6110basedpcramplificationfordetectingmycobacteriumtuberculosis AT masfiyahmasfiyah definitivediagnosisoftuberculousmeningitistbmdirsupdrkariadisemarangdescriptivestudyinadultpatientsusingis6110basedpcramplificationfordetectingmycobacteriumtuberculosis AT ariscaturbintoro definitivediagnosisoftuberculousmeningitistbmdirsupdrkariadisemarangdescriptivestudyinadultpatientsusingis6110basedpcramplificationfordetectingmycobacteriumtuberculosis AT purnomohadi definitivediagnosisoftuberculousmeningitistbmdirsupdrkariadisemarangdescriptivestudyinadultpatientsusingis6110basedpcramplificationfordetectingmycobacteriumtuberculosis |