Uncommon Terpenoids from <i>Salvia</i> Species: Chemistry, Biosynthesis and Biological Activities
The search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/3/1128 |
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| author | Salar Hafez Ghoran Fatemeh Taktaz Ali Akbar Mozafari Murat Tunçtürk Nazim Sekeroglu Anake Kijjoa |
| author_facet | Salar Hafez Ghoran Fatemeh Taktaz Ali Akbar Mozafari Murat Tunçtürk Nazim Sekeroglu Anake Kijjoa |
| author_sort | Salar Hafez Ghoran |
| collection | DOAJ |
| description | The search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of methodologies and concepts, one intriguing aspect still persists, i.e., different species belonging to the same genus can produce different secondary metabolites, whereas taxonomically different genera can produce the same compounds. The genus <i>Salvia</i> L. (Family Lamiaceae) comprises myriad distinct medicinal herbs used in traditional medicine worldwide that show different pharmacological activities due to the presence of a variety of interesting specialized metabolites, including mono-, sesqui-, di-, sester-, tri-, tetra-, and higher terpenoids as well as phenylpropanoids, phenolic acid derivatives, lignans, flavonoids, and alkaloids. We herein summarize the research progress on some uncommon terpenoids, isolated from members of the genus <i>Salvia</i>, which are well recognized for their potential pharmacological activities. This review also provides a current knowledge on the biosynthesis and occurrence of some interesting phytochemicals from <i>Salvia</i> species, <i>viz.</i> C<sub>23</sub>-terpenoids, sesterterpenoids (C<sub>25</sub>), dammarane triterpenoids (C<sub>30</sub>), and uncommon triterpenoids (C<sub>20</sub>+C<sub>10</sub>). The study was carried out by searching various scientific databases, including Elsevier, ACS publications, Taylor and Francis, Wiley Online Library, MDPI, Springer, Thieme, and ProQuest. Therefore, 106 uncommon terpenoids were identified and summarized. Some of these compounds possessed a variety of pharmacological properties, such as antibacterial, antiviral, antiparasitic, cytotoxic and tubulin tyrosine ligase inhibitory activities. Due to the lack of pharmacological information for the presented compounds gathered from previous studies, biological investigation of these compounds should be reinvestigated. |
| first_indexed | 2024-03-09T23:26:39Z |
| format | Article |
| id | doaj.art-afdf03b303a94e7a8960e1da52608fc8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T23:26:39Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-afdf03b303a94e7a8960e1da52608fc82023-11-23T17:18:03ZengMDPI AGMolecules1420-30492022-02-01273112810.3390/molecules27031128Uncommon Terpenoids from <i>Salvia</i> Species: Chemistry, Biosynthesis and Biological ActivitiesSalar Hafez Ghoran0Fatemeh Taktaz1Ali Akbar Mozafari2Murat Tunçtürk3Nazim Sekeroglu4Anake Kijjoa5Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Biology, Faculty of Sciences, University of Hakim Sabzevari, Sabzevar 96179-76487, IranMedicinal Plant Breeding & Development Research Institute, University of Kurdistan, Sanandaj 66177-15175, IranField Crop Department, Agricultural Faculty, Van Yuzuncu Yil University, Van 65090, TurkeyPhytotherapy, Medicinal and Aromatic Plants Application & Research Center and Biology Department, Faculty of Arts and Science, Gaziantep University, Gaziantep 27310, TurkeyICBAS—Instituto de Ciências Biomédicas Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, PortugalThe search for new bioactive compounds from plant sources has been and continues to be one of the most important fields of research in drug discovery. However, Natural Products research has continuously evolved, and more and more has gained a multidisciplinary character. Despite new developments of methodologies and concepts, one intriguing aspect still persists, i.e., different species belonging to the same genus can produce different secondary metabolites, whereas taxonomically different genera can produce the same compounds. The genus <i>Salvia</i> L. (Family Lamiaceae) comprises myriad distinct medicinal herbs used in traditional medicine worldwide that show different pharmacological activities due to the presence of a variety of interesting specialized metabolites, including mono-, sesqui-, di-, sester-, tri-, tetra-, and higher terpenoids as well as phenylpropanoids, phenolic acid derivatives, lignans, flavonoids, and alkaloids. We herein summarize the research progress on some uncommon terpenoids, isolated from members of the genus <i>Salvia</i>, which are well recognized for their potential pharmacological activities. This review also provides a current knowledge on the biosynthesis and occurrence of some interesting phytochemicals from <i>Salvia</i> species, <i>viz.</i> C<sub>23</sub>-terpenoids, sesterterpenoids (C<sub>25</sub>), dammarane triterpenoids (C<sub>30</sub>), and uncommon triterpenoids (C<sub>20</sub>+C<sub>10</sub>). The study was carried out by searching various scientific databases, including Elsevier, ACS publications, Taylor and Francis, Wiley Online Library, MDPI, Springer, Thieme, and ProQuest. Therefore, 106 uncommon terpenoids were identified and summarized. Some of these compounds possessed a variety of pharmacological properties, such as antibacterial, antiviral, antiparasitic, cytotoxic and tubulin tyrosine ligase inhibitory activities. Due to the lack of pharmacological information for the presented compounds gathered from previous studies, biological investigation of these compounds should be reinvestigated.https://www.mdpi.com/1420-3049/27/3/1128<i>Salvia</i> L.Lamiaceaesesterterpenoidsdammarane-type triterpenoidsuncommon triterpenoidscytotoxicity |
| spellingShingle | Salar Hafez Ghoran Fatemeh Taktaz Ali Akbar Mozafari Murat Tunçtürk Nazim Sekeroglu Anake Kijjoa Uncommon Terpenoids from <i>Salvia</i> Species: Chemistry, Biosynthesis and Biological Activities Molecules <i>Salvia</i> L. Lamiaceae sesterterpenoids dammarane-type triterpenoids uncommon triterpenoids cytotoxicity |
| title | Uncommon Terpenoids from <i>Salvia</i> Species: Chemistry, Biosynthesis and Biological Activities |
| title_full | Uncommon Terpenoids from <i>Salvia</i> Species: Chemistry, Biosynthesis and Biological Activities |
| title_fullStr | Uncommon Terpenoids from <i>Salvia</i> Species: Chemistry, Biosynthesis and Biological Activities |
| title_full_unstemmed | Uncommon Terpenoids from <i>Salvia</i> Species: Chemistry, Biosynthesis and Biological Activities |
| title_short | Uncommon Terpenoids from <i>Salvia</i> Species: Chemistry, Biosynthesis and Biological Activities |
| title_sort | uncommon terpenoids from i salvia i species chemistry biosynthesis and biological activities |
| topic | <i>Salvia</i> L. Lamiaceae sesterterpenoids dammarane-type triterpenoids uncommon triterpenoids cytotoxicity |
| url | https://www.mdpi.com/1420-3049/27/3/1128 |
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