Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda.
Recently the use of indoor residual spraying of insecticide (IRS) has greatly increased in Africa; however, limited data exist on the quantitative impacts of IRS on health outcomes in highly malaria endemic areas.Routine data were collected on more than 90,000 patient visits at a single health facil...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3412792?pdf=render |
| _version_ | 1818362835025002496 |
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| author | Ruth Kigozi Sanjiv M Baxi Anne Gasasira Asadu Sserwanga Stella Kakeeto Sussann Nasr Denis Rubahika Gunawardena Dissanayake Moses R Kamya Scott Filler Grant Dorsey |
| author_facet | Ruth Kigozi Sanjiv M Baxi Anne Gasasira Asadu Sserwanga Stella Kakeeto Sussann Nasr Denis Rubahika Gunawardena Dissanayake Moses R Kamya Scott Filler Grant Dorsey |
| author_sort | Ruth Kigozi |
| collection | DOAJ |
| description | Recently the use of indoor residual spraying of insecticide (IRS) has greatly increased in Africa; however, limited data exist on the quantitative impacts of IRS on health outcomes in highly malaria endemic areas.Routine data were collected on more than 90,000 patient visits at a single health facility over a 56 month period covering five rounds of IRS using three different insecticides. Temporal associations between the timing of IRS and the probability of a patient referred for microscopy having laboratory confirmed malaria were estimated controlling for seasonality and age. Considering patients less than five years of age there was a modest decrease in the odds of malaria following the 1(st) round of IRS using DDT (OR = 0.76, p<0.001) and the 2(nd) round using alpha-cypermethrin (OR = 0.83, p = 0.002). Following rounds 3-5 using bendiocarb there was a much greater decrease in the odds of malaria (ORs 0.34, 0.16, 0.17 respectively, p<0.001 for all comparisons). Overall, the impact of IRS was less pronounced among patients 5 years or older.IRS was associated with a reduction in malaria morbidity in an area of high transmission intensity in Uganda and the benefits appeared to be greatest after switching to a carbamate class of insecticide. |
| first_indexed | 2024-12-13T21:38:53Z |
| format | Article |
| id | doaj.art-afdf0ee2fa594b9b97beec6e9c99537d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T21:38:53Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-afdf0ee2fa594b9b97beec6e9c99537d2022-12-21T23:30:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4285710.1371/journal.pone.0042857Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda.Ruth KigoziSanjiv M BaxiAnne GasasiraAsadu SserwangaStella KakeetoSussann NasrDenis RubahikaGunawardena DissanayakeMoses R KamyaScott FillerGrant DorseyRecently the use of indoor residual spraying of insecticide (IRS) has greatly increased in Africa; however, limited data exist on the quantitative impacts of IRS on health outcomes in highly malaria endemic areas.Routine data were collected on more than 90,000 patient visits at a single health facility over a 56 month period covering five rounds of IRS using three different insecticides. Temporal associations between the timing of IRS and the probability of a patient referred for microscopy having laboratory confirmed malaria were estimated controlling for seasonality and age. Considering patients less than five years of age there was a modest decrease in the odds of malaria following the 1(st) round of IRS using DDT (OR = 0.76, p<0.001) and the 2(nd) round using alpha-cypermethrin (OR = 0.83, p = 0.002). Following rounds 3-5 using bendiocarb there was a much greater decrease in the odds of malaria (ORs 0.34, 0.16, 0.17 respectively, p<0.001 for all comparisons). Overall, the impact of IRS was less pronounced among patients 5 years or older.IRS was associated with a reduction in malaria morbidity in an area of high transmission intensity in Uganda and the benefits appeared to be greatest after switching to a carbamate class of insecticide.http://europepmc.org/articles/PMC3412792?pdf=render |
| spellingShingle | Ruth Kigozi Sanjiv M Baxi Anne Gasasira Asadu Sserwanga Stella Kakeeto Sussann Nasr Denis Rubahika Gunawardena Dissanayake Moses R Kamya Scott Filler Grant Dorsey Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda. PLoS ONE |
| title | Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda. |
| title_full | Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda. |
| title_fullStr | Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda. |
| title_full_unstemmed | Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda. |
| title_short | Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda. |
| title_sort | indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of uganda |
| url | http://europepmc.org/articles/PMC3412792?pdf=render |
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