The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy
Purpose: Generalized spike and wave discharges (SWD) are generated within the cortico-thalamo-cortical system. However the exact interactions between cortex and different thalamic nuclei needed for the generation and maintenance of SWD are still to be elucidated. This study aims to shed more light o...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-07-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996112000940 |
| _version_ | 1818576280129372160 |
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| author | Annika Lüttjohann Gilles van Luijtelaar |
| author_facet | Annika Lüttjohann Gilles van Luijtelaar |
| author_sort | Annika Lüttjohann |
| collection | DOAJ |
| description | Purpose: Generalized spike and wave discharges (SWD) are generated within the cortico-thalamo-cortical system. However the exact interactions between cortex and different thalamic nuclei needed for the generation and maintenance of SWD are still to be elucidated. This study aims to shed more light on these interactions via multisite cortical and thalamic local-field-potential recordings. Methods: WAG/Rij rats were equipped with multiple electrodes targeting layers 4 to 6 of the somatosensory-cortex, rostral and caudal RTN, VPM, anterior (ATN)- and posterior (Po) thalamic nucleus. The maximal-association-strength between signals was calculated for pre-ictal→ictal transition periods and in control periods using non-linear-association-analysis. Dynamics of changes in coupling-direction and time-delays between channels were analyzed. Results: Earliest and strongest increases in coupling-strength were seen between cortical layers 5/6 and Po. Other thalamic nuclei became later involved in SWD activity. During the first 500 ms of SWDs the cortex guided most thalamic nuclei while cortex and Po kept a bidirectional crosstalk. Most thalamic nuclei started to guide the Po until the end of the SWD. While the rostral RTN showed increased coupling with Po, the caudal RTN decoupled. Instead, it directed its activity to the rostral RTN. Conclusions: Next to the focal cortical instigator zone of SWDs, the Po seems crucial for their occurrence. This nucleus shows early increases in coupling and is the only nucleus which keeps a bidirectional crosstalk to the cortex within the first 500 ms of SWDs. Other thalamic nuclei seem to have only a function in SWD maintenance. Rostral and caudal-RTN have opposite roles in SWD occurrence. |
| first_indexed | 2024-12-16T06:11:30Z |
| format | Article |
| id | doaj.art-afe095cf214045deaf8683f36870024e |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-16T06:11:30Z |
| publishDate | 2012-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-afe095cf214045deaf8683f36870024e2022-12-21T22:41:23ZengElsevierNeurobiology of Disease1095-953X2012-07-014714960The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsyAnnika Lüttjohann0Gilles van Luijtelaar1Corresponding author at: Donders Center for Cognition, Radboud University Nijmegen, PO Box 9104, 6500 HE Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, The NetherlandsDonders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognition, Radboud University Nijmegen, Nijmegen, The NetherlandsPurpose: Generalized spike and wave discharges (SWD) are generated within the cortico-thalamo-cortical system. However the exact interactions between cortex and different thalamic nuclei needed for the generation and maintenance of SWD are still to be elucidated. This study aims to shed more light on these interactions via multisite cortical and thalamic local-field-potential recordings. Methods: WAG/Rij rats were equipped with multiple electrodes targeting layers 4 to 6 of the somatosensory-cortex, rostral and caudal RTN, VPM, anterior (ATN)- and posterior (Po) thalamic nucleus. The maximal-association-strength between signals was calculated for pre-ictal→ictal transition periods and in control periods using non-linear-association-analysis. Dynamics of changes in coupling-direction and time-delays between channels were analyzed. Results: Earliest and strongest increases in coupling-strength were seen between cortical layers 5/6 and Po. Other thalamic nuclei became later involved in SWD activity. During the first 500 ms of SWDs the cortex guided most thalamic nuclei while cortex and Po kept a bidirectional crosstalk. Most thalamic nuclei started to guide the Po until the end of the SWD. While the rostral RTN showed increased coupling with Po, the caudal RTN decoupled. Instead, it directed its activity to the rostral RTN. Conclusions: Next to the focal cortical instigator zone of SWDs, the Po seems crucial for their occurrence. This nucleus shows early increases in coupling and is the only nucleus which keeps a bidirectional crosstalk to the cortex within the first 500 ms of SWDs. Other thalamic nuclei seem to have only a function in SWD maintenance. Rostral and caudal-RTN have opposite roles in SWD occurrence.http://www.sciencedirect.com/science/article/pii/S0969996112000940Somatosensory cortexCortico-thalamo-cortical systemNetwork interactionsNon-linear association analysesPosterior thalamic nucleusSpike–wave discharges |
| spellingShingle | Annika Lüttjohann Gilles van Luijtelaar The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy Neurobiology of Disease Somatosensory cortex Cortico-thalamo-cortical system Network interactions Non-linear association analyses Posterior thalamic nucleus Spike–wave discharges |
| title | The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy |
| title_full | The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy |
| title_fullStr | The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy |
| title_full_unstemmed | The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy |
| title_short | The dynamics of cortico-thalamo-cortical interactions at the transition from pre-ictal to ictal LFPs in absence epilepsy |
| title_sort | dynamics of cortico thalamo cortical interactions at the transition from pre ictal to ictal lfps in absence epilepsy |
| topic | Somatosensory cortex Cortico-thalamo-cortical system Network interactions Non-linear association analyses Posterior thalamic nucleus Spike–wave discharges |
| url | http://www.sciencedirect.com/science/article/pii/S0969996112000940 |
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