Non-Coding RNAs and Prediction of Preeclampsia in the First Trimester of Pregnancy
Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality. The only fundamental treatment for PE is the termination of pregnancy. Therefore, not only severe maternal complications but also perinatal complications due to immaturity of the infant associated with early delive...
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MDPI AG
2022-08-01
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| author | Manabu Ogoyama Hironori Takahashi Hirotada Suzuki Akihide Ohkuchi Hiroyuki Fujiwara Toshihiro Takizawa |
| author_facet | Manabu Ogoyama Hironori Takahashi Hirotada Suzuki Akihide Ohkuchi Hiroyuki Fujiwara Toshihiro Takizawa |
| author_sort | Manabu Ogoyama |
| collection | DOAJ |
| description | Preeclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality. The only fundamental treatment for PE is the termination of pregnancy. Therefore, not only severe maternal complications but also perinatal complications due to immaturity of the infant associated with early delivery are serious issues. The treatment and prevention of preterm onset preeclampsia (POPE) are challenging. In 2017, the ASPRE trial showed that a low oral dose of aspirin administered to POPE high-risk women in early pregnancy reduced POPE by 62%. A prediction algorithm at 11–13 weeks of gestation identifies POPE with 75% sensitivity when the false positive rate is set at 10%. New biomarkers to increase the accuracy of the prediction model for POPE high-risk women in early pregnancy are needed. In this review, we focused on non-coding RNAs (ncRNAs) as potential biomarkers for the prediction of POPE. Highly expressed ncRNAs in the placenta in early pregnancy may play crucial roles in placentation. Furthermore, placenta-specific ncRNAs have been detected in maternal blood. In this review, we summarized ncRNAs that were highly expressed in the primary human placenta in early pregnancy. We also presented highly expressed ncRNAs in the placenta that were associated with or predictive of the development of PE in an expression analysis of maternal blood during the first trimester of pregnancy. These previous studies showed that the chromosome 19 microRNA (miRNA) -derived miRNAs (e.g., <i>miR-517-5p</i>, <i>miR-518b</i>, and <i>miR-520h</i>), the hypoxia-inducible miRNA (<i>miR-210</i>), and long non-coding RNA <i>H19</i>, were not only highly expressed in the early placenta but were also significantly up-regulated in the blood at early gestation in pregnant women who later developed PE. These maternal circulating ncRNAs in early pregnancy are expected to be possible biomarkers for POPE. |
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| series | Cells |
| spelling | doaj.art-afe17d15840449b4b505ea08235d7de12023-12-01T22:53:13ZengMDPI AGCells2073-44092022-08-011115242810.3390/cells11152428Non-Coding RNAs and Prediction of Preeclampsia in the First Trimester of PregnancyManabu Ogoyama0Hironori Takahashi1Hirotada Suzuki2Akihide Ohkuchi3Hiroyuki Fujiwara4Toshihiro Takizawa5Department of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke 329-0498, JapanDepartment of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke 329-0498, JapanDepartment of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke 329-0498, JapanDepartment of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke 329-0498, JapanDepartment of Obstetrics and Gynecology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke 329-0498, JapanDepartment of Molecular Medicine and Anatomy, Nippon Medical School, 1-1-5 Sendagi, Tokyo 113-8602, JapanPreeclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality. The only fundamental treatment for PE is the termination of pregnancy. Therefore, not only severe maternal complications but also perinatal complications due to immaturity of the infant associated with early delivery are serious issues. The treatment and prevention of preterm onset preeclampsia (POPE) are challenging. In 2017, the ASPRE trial showed that a low oral dose of aspirin administered to POPE high-risk women in early pregnancy reduced POPE by 62%. A prediction algorithm at 11–13 weeks of gestation identifies POPE with 75% sensitivity when the false positive rate is set at 10%. New biomarkers to increase the accuracy of the prediction model for POPE high-risk women in early pregnancy are needed. In this review, we focused on non-coding RNAs (ncRNAs) as potential biomarkers for the prediction of POPE. Highly expressed ncRNAs in the placenta in early pregnancy may play crucial roles in placentation. Furthermore, placenta-specific ncRNAs have been detected in maternal blood. In this review, we summarized ncRNAs that were highly expressed in the primary human placenta in early pregnancy. We also presented highly expressed ncRNAs in the placenta that were associated with or predictive of the development of PE in an expression analysis of maternal blood during the first trimester of pregnancy. These previous studies showed that the chromosome 19 microRNA (miRNA) -derived miRNAs (e.g., <i>miR-517-5p</i>, <i>miR-518b</i>, and <i>miR-520h</i>), the hypoxia-inducible miRNA (<i>miR-210</i>), and long non-coding RNA <i>H19</i>, were not only highly expressed in the early placenta but were also significantly up-regulated in the blood at early gestation in pregnant women who later developed PE. These maternal circulating ncRNAs in early pregnancy are expected to be possible biomarkers for POPE.https://www.mdpi.com/2073-4409/11/15/2428preeclampsianon-coding RNAplacentationfirst trimesterprediction |
| spellingShingle | Manabu Ogoyama Hironori Takahashi Hirotada Suzuki Akihide Ohkuchi Hiroyuki Fujiwara Toshihiro Takizawa Non-Coding RNAs and Prediction of Preeclampsia in the First Trimester of Pregnancy Cells preeclampsia non-coding RNA placentation first trimester prediction |
| title | Non-Coding RNAs and Prediction of Preeclampsia in the First Trimester of Pregnancy |
| title_full | Non-Coding RNAs and Prediction of Preeclampsia in the First Trimester of Pregnancy |
| title_fullStr | Non-Coding RNAs and Prediction of Preeclampsia in the First Trimester of Pregnancy |
| title_full_unstemmed | Non-Coding RNAs and Prediction of Preeclampsia in the First Trimester of Pregnancy |
| title_short | Non-Coding RNAs and Prediction of Preeclampsia in the First Trimester of Pregnancy |
| title_sort | non coding rnas and prediction of preeclampsia in the first trimester of pregnancy |
| topic | preeclampsia non-coding RNA placentation first trimester prediction |
| url | https://www.mdpi.com/2073-4409/11/15/2428 |
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