GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development

GRHL2 and AP2a coordinate early surface ectoderm lineage commitment during development

Summary: Ectodermal dysplasias including skin abnormalities and cleft lip/palate result from improper surface ectoderm (SE) patterning. However, the connection between SE gene regulatory networks and disease remains poorly understood. Here, we dissect human SE differentiation with multiomics and est...

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Bibliographic Details
Main Authors: Ann E. Collier, Samantha N. Piekos, Angela Liu, Jillian M. Pattison, Franco Felix, Alessandro A. Bailetti, Egor Sedov, Sadhana Gaddam, Hanson Zhen, Anthony E. Oro
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Biological sciences
Cell biology
Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422300202X

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