Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series
Prurigo simplex or “itchy red bump” disease is a controversial pruritic papular eruption. The objective of this study was to delineate the diagnostic criteria for this disease. A PubMed search was performed for: “prurigo simplex”, “prurigo simplex subacuta”, “subacute prurigo”, “chronic papular derm...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2021-09-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3912
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| _version_ | 1828128263718830080 |
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| author | Joanna Wallengren |
| author_facet | Joanna Wallengren |
| author_sort | Joanna Wallengren |
| collection | DOAJ |
| description | Prurigo simplex or “itchy red bump” disease is a controversial pruritic papular eruption. The objective of this study was to delineate the diagnostic criteria for this disease. A PubMed search was performed for: “prurigo simplex”, “prurigo simplex subacuta”, “subacute prurigo”, “chronic papular dermatitis in adults” and “itchy red bump disease”. Medical charts of patients with prurigo diagnoses in a university setting were analysed. The literature search revealed 32 relevant studies (431 patients) on different aspects of the disease. Out of 50 patients with prurigo diagnoses, 5 patients (4 women, mean age at onset 54 years) matched the description in literature. Small, severely itchy papules without secondary skin lesions continued to appear for years (mean 5.6 years). Skin biopsies revealed lymphocytic perivascular infiltrates, few eosinophils and occasionally spongiosis. Treatment with long-term methotrexate or cyclosporine cleared the symptoms. Some major and minor diagnostic criteria for prurigo simplex are proposed and compared with chronic prurigo. |
| first_indexed | 2024-04-11T16:01:47Z |
| format | Article |
| id | doaj.art-afe5d7adc05843bf8e0dc9a6a9e1c03a |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-04-11T16:01:47Z |
| publishDate | 2021-09-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-afe5d7adc05843bf8e0dc9a6a9e1c03a2022-12-22T04:15:00ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572021-09-011019adv0053910.2340/00015555-39127056Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case SeriesJoanna Wallengren0 Department of Clinical Sciences Lund, Dermatology and Venereology, Lund University, Skane University Hospital, SE-221 85 Lund, Sweden. Prurigo simplex or “itchy red bump” disease is a controversial pruritic papular eruption. The objective of this study was to delineate the diagnostic criteria for this disease. A PubMed search was performed for: “prurigo simplex”, “prurigo simplex subacuta”, “subacute prurigo”, “chronic papular dermatitis in adults” and “itchy red bump disease”. Medical charts of patients with prurigo diagnoses in a university setting were analysed. The literature search revealed 32 relevant studies (431 patients) on different aspects of the disease. Out of 50 patients with prurigo diagnoses, 5 patients (4 women, mean age at onset 54 years) matched the description in literature. Small, severely itchy papules without secondary skin lesions continued to appear for years (mean 5.6 years). Skin biopsies revealed lymphocytic perivascular infiltrates, few eosinophils and occasionally spongiosis. Treatment with long-term methotrexate or cyclosporine cleared the symptoms. Some major and minor diagnostic criteria for prurigo simplex are proposed and compared with chronic prurigo. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3912 prurigo simplex itchy red bump disease chronic prurigo pruritus itch immunosuppressants |
| spellingShingle | Joanna Wallengren Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series Acta Dermato-Venereologica prurigo simplex itchy red bump disease chronic prurigo pruritus itch immunosuppressants |
| title | Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series |
| title_full | Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series |
| title_fullStr | Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series |
| title_full_unstemmed | Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series |
| title_short | Prurigo Simplex or “Itchy Red Bump” Disease: Review and Case Series |
| title_sort | prurigo simplex or itchy red bump disease review and case series |
| topic | prurigo simplex itchy red bump disease chronic prurigo pruritus itch immunosuppressants |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3912
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| work_keys_str_mv | AT joannawallengren prurigosimplexoritchyredbumpdiseasereviewandcaseseries |