Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats

Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats

IntroductionHuman zona pellucida (ZP) plays an important role in reproductive process. Several rare mutations in the encoding genes (ZP1, ZP2, and ZP3) have been demonstrated to cause women infertility. Mutations in ZP2 have been reported to cause ZP defects or empty follicle syndrome. We aimed to i...

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Bibliographic Details
Main Authors: Jun Zeng, Ying Sun, Jing Zhang, Xiaozhu Wu, Yan Wang, Ruping Quan, Wanjuan Song, Dan Guo, Shengran Wang, Jianlin Chen, Hongmei Xiao, Hua-Lin Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Endocrinology
Subjects:
ZP2
female infertility
rat model
single-cell RNA sequencing
TGF-β signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1169378/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1169378/full

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