Aetiopathology of canine hepatitis in Kerala
Hepatitis in dogs could be due to infectious, toxic or metabolic causes. Among infectious causes, leptospira, canine adenovirus (CAV 1) and babesia are responsible at varying levels, depending on the local geo-climatic conditions. This study, conducted on 40 dogs with clinical signs of hepatitis...
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| Format: | Article |
| Language: | English |
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Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2023-06-01
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| Series: | Journal of Veterinary and Animal Sciences |
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| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_ry170f.pdf?t=ry170f |
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| author | Alphiya Joseph K. Vinodkumar P. V. Tresamol K. Vijayakumar I. S Sajitha |
| author_facet | Alphiya Joseph K. Vinodkumar P. V. Tresamol K. Vijayakumar I. S Sajitha |
| author_sort | Alphiya Joseph |
| collection | DOAJ |
| description | Hepatitis in dogs could be due to infectious, toxic or metabolic causes. Among infectious
causes, leptospira, canine adenovirus (CAV 1) and babesia are responsible at varying levels,
depending on the local geo-climatic conditions. This study, conducted on 40 dogs with clinical signs
of hepatitis in Thrissur, Kerala, revealed occurrence of 2.5 per cent (1/40) for CAV 1, 20 per cent
(8/40) for leptospirosis and 22.5 per cent (9/40) for babesiosis. The aetiologies were confirmed by
polymerase chain reaction (PCR) targeting the E3 gene for CAV 1, microscopic agglutination test
(MAT) for leptospirosis and peripheral blood smear examination for babesiosis. Haematological
profile of CAV 1 infected animals revealed thrombocytopaenia, lymphopaenia, monocytopaenia
and granulocytosis. Serum biochemical analysis divulged elevated alanine aminotransferase (ALT),
alkaline phosphatase (ALP), aspartate aminotransferase (AST), total bilirubin and creatinine, with
decreased total protein and albumin. Significant decrease in volume of packed red cells (VPRC),
haemoglobin (Hb) and total erythrocyte count (TEC), with significant increase in total leukocyte
count (TLC) were evident in dogs positive for leptospirosis. Serum biochemical analysis revealed
significant increase in ALP, AST and blood urea nitrogen (BUN) and significant decrease in total
protein. Severe anaemia and thrombocytopenia with mild leucocytosis and significant increase in
ALP and total bilirubin, with hypoproteinemia were noticed in animals with babesiosis. |
| first_indexed | 2024-03-12T22:40:35Z |
| format | Article |
| id | doaj.art-afe70d9d32304420b03d636535de450a |
| institution | Directory Open Access Journal |
| issn | 0971-0701 2582-0605 |
| language | English |
| last_indexed | 2024-03-12T22:40:35Z |
| publishDate | 2023-06-01 |
| publisher | Director of Academics and Research, Kerala Veterinary and Animal Sciences University |
| record_format | Article |
| series | Journal of Veterinary and Animal Sciences |
| spelling | doaj.art-afe70d9d32304420b03d636535de450a2023-07-21T09:42:47ZengDirector of Academics and Research, Kerala Veterinary and Animal Sciences UniversityJournal of Veterinary and Animal Sciences0971-07012582-06052023-06-0154247748510.51966/jvas.2023.54.2.477-485Aetiopathology of canine hepatitis in KeralaAlphiya Joseph0https://orcid.org/0009-0007-8667-1137K. Vinodkumar1https://orcid.org/0000-0001-9643-7976P. V. Tresamol2https://orcid.org/0000-0002-8270-2967K. Vijayakumar 3https://orcid.org/0000-0001-5550-2620I. S Sajitha4https://orcid.org/0000-0002-0315-6081MVSc Scholar, Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy – 680651, Kerala Veterinary and Animal Sciences University, Kerala,IndiaAssistant Professor, Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy – 680651, Kerala Veterinary and Animal Sciences University, Kerala,IndiaProfessor and Head, Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences, Mannuthy – 680651, Kerala Veterinary and Animal Sciences University, Kerala,IndiaDean, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, India Assistant Professor, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680 651, Kerala Veterinary and Animal Sciences University, Kerala, India Hepatitis in dogs could be due to infectious, toxic or metabolic causes. Among infectious causes, leptospira, canine adenovirus (CAV 1) and babesia are responsible at varying levels, depending on the local geo-climatic conditions. This study, conducted on 40 dogs with clinical signs of hepatitis in Thrissur, Kerala, revealed occurrence of 2.5 per cent (1/40) for CAV 1, 20 per cent (8/40) for leptospirosis and 22.5 per cent (9/40) for babesiosis. The aetiologies were confirmed by polymerase chain reaction (PCR) targeting the E3 gene for CAV 1, microscopic agglutination test (MAT) for leptospirosis and peripheral blood smear examination for babesiosis. Haematological profile of CAV 1 infected animals revealed thrombocytopaenia, lymphopaenia, monocytopaenia and granulocytosis. Serum biochemical analysis divulged elevated alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), total bilirubin and creatinine, with decreased total protein and albumin. Significant decrease in volume of packed red cells (VPRC), haemoglobin (Hb) and total erythrocyte count (TEC), with significant increase in total leukocyte count (TLC) were evident in dogs positive for leptospirosis. Serum biochemical analysis revealed significant increase in ALP, AST and blood urea nitrogen (BUN) and significant decrease in total protein. Severe anaemia and thrombocytopenia with mild leucocytosis and significant increase in ALP and total bilirubin, with hypoproteinemia were noticed in animals with babesiosis.https://jvas.in/public_html/upload/article_file/article_file_ry170f.pdf?t=ry170finfectious canine hepatitiscanine adenovirus 1leptospirosisbabesiosis |
| spellingShingle | Alphiya Joseph K. Vinodkumar P. V. Tresamol K. Vijayakumar I. S Sajitha Aetiopathology of canine hepatitis in Kerala Journal of Veterinary and Animal Sciences infectious canine hepatitis canine adenovirus 1 leptospirosis babesiosis |
| title | Aetiopathology of canine hepatitis in Kerala |
| title_full | Aetiopathology of canine hepatitis in Kerala |
| title_fullStr | Aetiopathology of canine hepatitis in Kerala |
| title_full_unstemmed | Aetiopathology of canine hepatitis in Kerala |
| title_short | Aetiopathology of canine hepatitis in Kerala |
| title_sort | aetiopathology of canine hepatitis in kerala |
| topic | infectious canine hepatitis canine adenovirus 1 leptospirosis babesiosis |
| url | https://jvas.in/public_html/upload/article_file/article_file_ry170f.pdf?t=ry170f |
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