Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia
Purpose: This article presents a case of panuveitis that occurred after unrelated allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a patient with lymphoma-type human T-cell leukemia virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL). Observations: A 45-year-old man develop...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993622004194 |
| _version_ | 1818513508479795200 |
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| author | Atsunobu Takeda Teppei Sakoda Nobuyo Yawata Koji Kato Eiichi Hasegawa Takahiro Shima Shinichi Hikita Keiko Yoshitomi Katsuto Takenaka Yoshinao Oda Koichi Akashi Koh-Hei Sonoda |
| author_facet | Atsunobu Takeda Teppei Sakoda Nobuyo Yawata Koji Kato Eiichi Hasegawa Takahiro Shima Shinichi Hikita Keiko Yoshitomi Katsuto Takenaka Yoshinao Oda Koichi Akashi Koh-Hei Sonoda |
| author_sort | Atsunobu Takeda |
| collection | DOAJ |
| description | Purpose: This article presents a case of panuveitis that occurred after unrelated allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a patient with lymphoma-type human T-cell leukemia virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL). Observations: A 45-year-old man developed unilateral panuveitis 18 months after undergoing allo-HSCT. He underwent vitrectomy, and depositions of grey-white granules localized on the retinal artery were observed in the eye. Cytological examination of the vitreous aspirates showed that the atypical lymphoid cells stained positive for CD3 and CD8, but negative for CD4, B-cell markers, and cytomegalovirus antigen. Interphase fluorescence in situ hybridization using X‐ and Y‐chromosome probes revealed complete donor chimerism in CD8+ T cells in the vitreous aspirates. Conclusions and importance: Donor-derived CD8+ T lymphocytes can induce panuveitis like HTLV-1-assiciated uveitis after allo-HSCT in patients with ATL. Pathological diagnosis of vitreous infiltration by vitrectomy is helpful in patients with ATL. Donor-derived CD8+ T lymphocytes-induced panuveitis is recurrent but susceptible to regional corticosteroid treatment. |
| first_indexed | 2024-12-11T00:02:27Z |
| format | Article |
| id | doaj.art-afe7286dc301400e8d256b4f9f88fb50 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-11T00:02:27Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-afe7286dc301400e8d256b4f9f88fb502022-12-22T01:28:25ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362022-09-0127101673Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemiaAtsunobu Takeda0Teppei Sakoda1Nobuyo Yawata2Koji Kato3Eiichi Hasegawa4Takahiro Shima5Shinichi Hikita6Keiko Yoshitomi7Katsuto Takenaka8Yoshinao Oda9Koichi Akashi10Koh-Hei Sonoda11Department of Ophthalmology, Japan; Corresponding author. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.Department of Medicine and Biosystemic Science, JapanDepartment of Ophthalmology, Japan; Department of Ocular Pathology and Imaging Science, JapanDepartment of Medicine and Biosystemic Science, JapanDepartment of Ophthalmology, JapanDepartment of Medicine and Biosystemic Science, JapanDepartment of Ophthalmology, JapanDepartment of Ophthalmology, JapanDepartment of Hematology, Clinical Immunology, and Infectious Diseases, Graduate School of Medicine, Ehime University, JapanDepartment of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Medicine and Biosystemic Science, JapanDepartment of Ophthalmology, Japan; Department of Ocular Pathology and Imaging Science, JapanPurpose: This article presents a case of panuveitis that occurred after unrelated allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a patient with lymphoma-type human T-cell leukemia virus type-1 (HTLV-1)-associated adult T-cell leukemia (ATL). Observations: A 45-year-old man developed unilateral panuveitis 18 months after undergoing allo-HSCT. He underwent vitrectomy, and depositions of grey-white granules localized on the retinal artery were observed in the eye. Cytological examination of the vitreous aspirates showed that the atypical lymphoid cells stained positive for CD3 and CD8, but negative for CD4, B-cell markers, and cytomegalovirus antigen. Interphase fluorescence in situ hybridization using X‐ and Y‐chromosome probes revealed complete donor chimerism in CD8+ T cells in the vitreous aspirates. Conclusions and importance: Donor-derived CD8+ T lymphocytes can induce panuveitis like HTLV-1-assiciated uveitis after allo-HSCT in patients with ATL. Pathological diagnosis of vitreous infiltration by vitrectomy is helpful in patients with ATL. Donor-derived CD8+ T lymphocytes-induced panuveitis is recurrent but susceptible to regional corticosteroid treatment.http://www.sciencedirect.com/science/article/pii/S2451993622004194Adult T cell leukemiaAllogeneic hematopoietic stem cell transplantationHuman T-cell lymphotropic virus type-1Donor-derived CD8+ T lymphocytesHTLV-1-Associated uveitis |
| spellingShingle | Atsunobu Takeda Teppei Sakoda Nobuyo Yawata Koji Kato Eiichi Hasegawa Takahiro Shima Shinichi Hikita Keiko Yoshitomi Katsuto Takenaka Yoshinao Oda Koichi Akashi Koh-Hei Sonoda Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia American Journal of Ophthalmology Case Reports Adult T cell leukemia Allogeneic hematopoietic stem cell transplantation Human T-cell lymphotropic virus type-1 Donor-derived CD8+ T lymphocytes HTLV-1-Associated uveitis |
| title | Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia |
| title_full | Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia |
| title_fullStr | Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia |
| title_full_unstemmed | Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia |
| title_short | Panuveitis induced by donor-derived CD8+ T cells after allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia |
| title_sort | panuveitis induced by donor derived cd8 t cells after allogeneic hematopoietic stem cell transplantation for adult t cell leukemia |
| topic | Adult T cell leukemia Allogeneic hematopoietic stem cell transplantation Human T-cell lymphotropic virus type-1 Donor-derived CD8+ T lymphocytes HTLV-1-Associated uveitis |
| url | http://www.sciencedirect.com/science/article/pii/S2451993622004194 |
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