Diagnostic and Therapeutic Perspectives Associated to Cobalamin-Dependent Metabolism and Transcobalamins’ Synthesis in Solid Cancers
Cobalamin or vitamin B12 (B12) is a cofactor for methionine synthase and methylmalonyl-CoA mutase, two enzymes implicated in key pathways for cell proliferation: methylation, purine synthesis, succinylation and ATP production. Ensuring these functions in cancer cells therefore requires important cob...
Main Authors: | Valentin Lacombe, Guy Lenaers, Geoffrey Urbanski |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-05-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6643/14/10/2058 |
Similar Items
-
Diagnostic reliability of serum active B12 (holo-transcobalamin) in true evaluation of vitamin B12 deficiency: Relevance in current perspective
by: Rinini Dastidar, et al.
Published: (2022-10-01) -
Transcobalamin II Deficiency in Four Cases with Novel Mutations
by: Sule Unal, et al.
Published: (2015-11-01) -
Transcobalamin Deficiency with the Mutation of Tcn2 in Children with the Primary Diagnosis of Methylmalonic Academia
by: Sara Nikpour, et al.
Published: (2023-07-01) -
Biological Activity of Pseudovitamin B<sub>12</sub> on Cobalamin-Dependent Methylmalonyl-CoA Mutase and Methionine Synthase in Mammalian Cultured COS-7 Cells
by: Tomohiro Bito, et al.
Published: (2020-07-01) -
Case report: Novel compound-heterozygous mutations in the TCN2 gene identified in a chinese girl with transcobalamin deficiency
by: Juan Luo, et al.
Published: (2022-08-01)