Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer
Monocytes and their tissue counterpart macrophages (MP) constitute the front line of the immune system. Indeed, they are able to rapidly and efficiently detect both external and internal danger signals, thereby activating the immune system to eradicate the disturbing biological, chemical, or physica...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1496 |
| _version_ | 1797487394632499200 |
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| author | Yannick Degboé Rémy Poupot Mary Poupot |
| author_facet | Yannick Degboé Rémy Poupot Mary Poupot |
| author_sort | Yannick Degboé |
| collection | DOAJ |
| description | Monocytes and their tissue counterpart macrophages (MP) constitute the front line of the immune system. Indeed, they are able to rapidly and efficiently detect both external and internal danger signals, thereby activating the immune system to eradicate the disturbing biological, chemical, or physical agents. They are also in charge of the control of the immune response and account for the repair of the damaged tissues, eventually restoring tissue homeostasis. The balance between these dual activities must be thoroughly controlled in space and time. Any sustained unbalanced response of MP leads to pathological disorders, such as chronic inflammation, or favors cancer development and progression. In this review, we take advantage of our expertise in chronic inflammation, especially in rheumatoid arthritis, and in cancer, to highlight the pivotal role of MP in the physiopathology of these disorders and to emphasize the repolarization of unbalanced MP as a promising therapeutic strategy to control these diseases. |
| first_indexed | 2024-03-09T23:47:01Z |
| format | Article |
| id | doaj.art-afe7af9e4c464ece98b9c01237e91dcb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:47:01Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-afe7af9e4c464ece98b9c01237e91dcb2023-11-23T16:41:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-01233149610.3390/ijms23031496Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and CancerYannick Degboé0Rémy Poupot1Mary Poupot2Infinity, Université Toulouse, CNRS, INSERM, UPS, 31024 Toulouse, FranceInfinity, Université Toulouse, CNRS, INSERM, UPS, 31024 Toulouse, FranceCentre de Recherche en Cancérologie de Toulouse, Université Toulouse, INSERM, UPS, 31037 Toulouse, FranceMonocytes and their tissue counterpart macrophages (MP) constitute the front line of the immune system. Indeed, they are able to rapidly and efficiently detect both external and internal danger signals, thereby activating the immune system to eradicate the disturbing biological, chemical, or physical agents. They are also in charge of the control of the immune response and account for the repair of the damaged tissues, eventually restoring tissue homeostasis. The balance between these dual activities must be thoroughly controlled in space and time. Any sustained unbalanced response of MP leads to pathological disorders, such as chronic inflammation, or favors cancer development and progression. In this review, we take advantage of our expertise in chronic inflammation, especially in rheumatoid arthritis, and in cancer, to highlight the pivotal role of MP in the physiopathology of these disorders and to emphasize the repolarization of unbalanced MP as a promising therapeutic strategy to control these diseases.https://www.mdpi.com/1422-0067/23/3/1496cancerdendrimermacrophagesmonocyteosteoclastpolarization |
| spellingShingle | Yannick Degboé Rémy Poupot Mary Poupot Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer International Journal of Molecular Sciences cancer dendrimer macrophages monocyte osteoclast polarization |
| title | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
| title_full | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
| title_fullStr | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
| title_full_unstemmed | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
| title_short | Repolarization of Unbalanced Macrophages: Unmet Medical Need in Chronic Inflammation and Cancer |
| title_sort | repolarization of unbalanced macrophages unmet medical need in chronic inflammation and cancer |
| topic | cancer dendrimer macrophages monocyte osteoclast polarization |
| url | https://www.mdpi.com/1422-0067/23/3/1496 |
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