EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity
Immunosuppression is a characteristic feature of chronic leishmaniasis. The dynamicity and the functional cross talks of host immune responses during Leishmania infection are still not clearly understood. Here we explored the functional aspects of accumulation of immune suppressive cellular and cyto...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.00616/full |
| _version_ | 1819035260407513088 |
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| author | Mohammad Asad Abdus Sabur Mohammad Shadab Sonali Das Mohd. Kamran Nicky Didwania Nahid Ali |
| author_facet | Mohammad Asad Abdus Sabur Mohammad Shadab Sonali Das Mohd. Kamran Nicky Didwania Nahid Ali |
| author_sort | Mohammad Asad |
| collection | DOAJ |
| description | Immunosuppression is a characteristic feature of chronic leishmaniasis. The dynamicity and the functional cross talks of host immune responses during Leishmania infection are still not clearly understood. Here we explored the functional aspects of accumulation of immune suppressive cellular and cytokine milieu during the progression of murine visceral leishmaniasis. In addition to IL-10 and TGF-β, investigation on the responses of different subunit chains of IL-12 family revealed a progressive elevation of EBI-3 and p35 chains of IL-35 with Leishmania donovani infection in BALB/c mice. The expansion of CD25 and FoxP3 positive T cells is associated with loss of IFN-γ and TNF-α response in advanced disease. Ex-vivo and in vivo neutralization of TGF-β and EBI-3 suggests a synergism in suppression of host anti-leishmanial immunity. The down-regulation of EBI-3 and TGF-β is crucial for re-activation of JAK-STAT pathway for induction as well as restoration of protective immunity against L. donovani infection. |
| first_indexed | 2024-12-21T07:46:48Z |
| format | Article |
| id | doaj.art-afe80a629bd548e482802948cf0ff4a3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T07:46:48Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-afe80a629bd548e482802948cf0ff4a32022-12-21T19:11:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-04-011010.3389/fimmu.2019.00616415931EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial ImmunityMohammad AsadAbdus SaburMohammad ShadabSonali DasMohd. KamranNicky DidwaniaNahid AliImmunosuppression is a characteristic feature of chronic leishmaniasis. The dynamicity and the functional cross talks of host immune responses during Leishmania infection are still not clearly understood. Here we explored the functional aspects of accumulation of immune suppressive cellular and cytokine milieu during the progression of murine visceral leishmaniasis. In addition to IL-10 and TGF-β, investigation on the responses of different subunit chains of IL-12 family revealed a progressive elevation of EBI-3 and p35 chains of IL-35 with Leishmania donovani infection in BALB/c mice. The expansion of CD25 and FoxP3 positive T cells is associated with loss of IFN-γ and TNF-α response in advanced disease. Ex-vivo and in vivo neutralization of TGF-β and EBI-3 suggests a synergism in suppression of host anti-leishmanial immunity. The down-regulation of EBI-3 and TGF-β is crucial for re-activation of JAK-STAT pathway for induction as well as restoration of protective immunity against L. donovani infection.https://www.frontiersin.org/article/10.3389/fimmu.2019.00616/fullregulatory T cellsLeishmaniaimmune responseinterleukin-35transforming growth factor betaimmune suppression |
| spellingShingle | Mohammad Asad Abdus Sabur Mohammad Shadab Sonali Das Mohd. Kamran Nicky Didwania Nahid Ali EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity Frontiers in Immunology regulatory T cells Leishmania immune response interleukin-35 transforming growth factor beta immune suppression |
| title | EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity |
| title_full | EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity |
| title_fullStr | EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity |
| title_full_unstemmed | EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity |
| title_short | EBI-3 Chain of IL-35 Along With TGF-β Synergistically Regulate Anti-leishmanial Immunity |
| title_sort | ebi 3 chain of il 35 along with tgf β synergistically regulate anti leishmanial immunity |
| topic | regulatory T cells Leishmania immune response interleukin-35 transforming growth factor beta immune suppression |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.00616/full |
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