Osteocalcin modulates parathyroid cell function in human parathyroid tumors

Osteocalcin modulates parathyroid cell function in human parathyroid tumors

IntroductionThe bone matrix protein osteocalcin (OC), secreted by osteoblasts, displays endocrine effects. We tested the hypothesis that OC modulates parathyroid tumor cell function.MethodsPrimary cell cultures derived from parathyroid adenomas (PAds) and HEK293 cells transiently transfected with th...

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Bibliographic Details
Main Authors: Chiara Verdelli, Giulia Stefania Tavanti, Irene Forno, Valentina Vaira, Riccardo Maggiore, Leonardo Vicentini, Paolo Dalino Ciaramella, Francesca Perticone, Giovanni Lombardi, Sabrina Corbetta
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
parathyroid tumor
osteocalcin
CASR
GPRC6A
ERK
beta-catenin
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1129930/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1129930/full

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