Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy
INTRODUCTION: The unpredictability of prostate cancer has become a daily challenge for the urologist, with different strategies being required to manage these cases. In this study, we report on the perspectives for curing prostate cancer in males undergoing radical prostatectomy with Gleason score o...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2005-06-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382005000300005 |
| _version_ | 1818503831491706880 |
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| author | Marcos F. Dall'oglio Alexandre Crippa Alberto A. Antunes Luciano J. Nesrallah Katia R. Leite Miguel Srougi |
| author_facet | Marcos F. Dall'oglio Alexandre Crippa Alberto A. Antunes Luciano J. Nesrallah Katia R. Leite Miguel Srougi |
| author_sort | Marcos F. Dall'oglio |
| collection | DOAJ |
| description | INTRODUCTION: The unpredictability of prostate cancer has become a daily challenge for the urologist, with different strategies being required to manage these cases. In this study, we report on the perspectives for curing prostate cancer in males undergoing radical prostatectomy with Gleason score of 2-6 on prostate biopsy in relation to pre-operative PSA levels. MATERIALS AND METHODS: From 1991 - 2000, we selected 440 individuals whose pathological diagnosis revealed a Gleason score of 2-6 upon prostate biopsy and who subsequently underwent retro-pubic radical prostatectomy due to localized prostate cancer. The clinical stage identified in the group under study was T1c: 206 (46.8%); T2a: 122 (27.7%); T2b: 93 (21.1%); T2c: 17 (3.9%); T3a: 2 (0.5%). Following surgery, we constructed a biochemical recurrence-free survival curve according to pre-operative PSA levels between 0-4; 4.1-10; 10.1-20 and > 20 ng/mL, with a median follow-up of 5 years. RESULTS: Following radical prostatectomy, the pathological stage was confirmed as pT2a: 137 (31.1%); T2b: 118 (26.8%); T2c: 85 (19.3%); T3a: 67 (15.2%); T3b: 6 (1.4%); T3c: 22 (5%). The biochemical recurrence-free survival, according to PSA values between 0-4; 4.1-10; 10.1-20 and > 20 ng/mL, was 86.6%, 62.7%, 39.8% and 24.8% respectively. CONCLUSION: Better chances for curing low-grade prostate cancer occur in individuals with normal PSA for whom a biopsy is not usually recommended. |
| first_indexed | 2024-12-10T21:29:07Z |
| format | Article |
| id | doaj.art-afe859d2956d4a479a78310e5267a77a |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-12-10T21:29:07Z |
| publishDate | 2005-06-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-afe859d2956d4a479a78310e5267a77a2022-12-22T01:32:53ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192005-06-0131322222710.1590/S1677-55382005000300005Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomyMarcos F. Dall'oglioAlexandre CrippaAlberto A. AntunesLuciano J. NesrallahKatia R. LeiteMiguel SrougiINTRODUCTION: The unpredictability of prostate cancer has become a daily challenge for the urologist, with different strategies being required to manage these cases. In this study, we report on the perspectives for curing prostate cancer in males undergoing radical prostatectomy with Gleason score of 2-6 on prostate biopsy in relation to pre-operative PSA levels. MATERIALS AND METHODS: From 1991 - 2000, we selected 440 individuals whose pathological diagnosis revealed a Gleason score of 2-6 upon prostate biopsy and who subsequently underwent retro-pubic radical prostatectomy due to localized prostate cancer. The clinical stage identified in the group under study was T1c: 206 (46.8%); T2a: 122 (27.7%); T2b: 93 (21.1%); T2c: 17 (3.9%); T3a: 2 (0.5%). Following surgery, we constructed a biochemical recurrence-free survival curve according to pre-operative PSA levels between 0-4; 4.1-10; 10.1-20 and > 20 ng/mL, with a median follow-up of 5 years. RESULTS: Following radical prostatectomy, the pathological stage was confirmed as pT2a: 137 (31.1%); T2b: 118 (26.8%); T2c: 85 (19.3%); T3a: 67 (15.2%); T3b: 6 (1.4%); T3c: 22 (5%). The biochemical recurrence-free survival, according to PSA values between 0-4; 4.1-10; 10.1-20 and > 20 ng/mL, was 86.6%, 62.7%, 39.8% and 24.8% respectively. CONCLUSION: Better chances for curing low-grade prostate cancer occur in individuals with normal PSA for whom a biopsy is not usually recommended.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382005000300005prostatic neoplasmsprostate-specific antigendiagnosisbiopsyprostatectomy |
| spellingShingle | Marcos F. Dall'oglio Alexandre Crippa Alberto A. Antunes Luciano J. Nesrallah Katia R. Leite Miguel Srougi Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy International Brazilian Journal of Urology prostatic neoplasms prostate-specific antigen diagnosis biopsy prostatectomy |
| title | Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy |
| title_full | Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy |
| title_fullStr | Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy |
| title_full_unstemmed | Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy |
| title_short | Survival of patients with prostate cancer and normal PSA levels treated by radical prostatectomy |
| title_sort | survival of patients with prostate cancer and normal psa levels treated by radical prostatectomy |
| topic | prostatic neoplasms prostate-specific antigen diagnosis biopsy prostatectomy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382005000300005 |
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