BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata
Marine organisms, in particular nudibranchs (Mollusca: nudibranchia), are known as a rich source of chemically diverse secondary metabolites exhibiting potential as antimalarial, anti-inflammatory, antiviral and anticancer activity. We presented the chemical investigation of an extract of nudibranch...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2016-04-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1065 |
| _version_ | 1818264621703757824 |
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| author | I Wayan Mudianta Ni Wayan Martiningsih I Nyoman Dodik Prasetia Muhammad Nursid |
| author_facet | I Wayan Mudianta Ni Wayan Martiningsih I Nyoman Dodik Prasetia Muhammad Nursid |
| author_sort | I Wayan Mudianta |
| collection | DOAJ |
| description | Marine organisms, in particular nudibranchs (Mollusca: nudibranchia), are known as a rich source of chemically diverse secondary metabolites exhibiting potential as antimalarial, anti-inflammatory, antiviral and anticancer activity. We presented the chemical investigation of an extract of nudibranch Hypselodoris infucata collected from Bali, an unexplored water but rich in nudibranch diversity. The extract contained the known (–)-furodysinin (1), a furanosesquiterpene that for the first time isolated from this species. Metabolite 1 was purified by chromatography and the structure was characterised by comparison of 1H NMR data with that of the reported data. The absolute configuration was determined by comparing the optical rotation values with the known enantiomer. In vitro cytotoxic activity of compound 1 against HeLa cell line displayed an IC50 at 102.7µg/mL. We also report for the first time the development of a method to assay nudibranch extracts for their feeding deterrence activity against local shrimps Penaeus vannamei. The extract show food rejection with highly significant difference in respect to the control (P = 0.0061) at natural concentration of 3.0mg/mL. |
| first_indexed | 2024-12-12T19:37:50Z |
| format | Article |
| id | doaj.art-afe9d5886e3c48ccb15c6ae7b6265d97 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-12T19:37:50Z |
| publishDate | 2016-04-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-afe9d5886e3c48ccb15c6ae7b6265d972022-12-22T00:14:15ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862016-04-01272104110http://dx.doi.org/10.14499/indonesianjpharm27iss2pp104BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucataI Wayan Mudianta0Ni Wayan Martiningsih1I Nyoman Dodik Prasetia2Muhammad Nursid3Dept of Analytical Chemistry, Ganesha Univ. of Education, Jl. Udayana No. 11 Singaraja, Bali 81116Dept of Analytical Chemistry, Ganesha Univ. of Education, Jl. Udayana No. 11 Singaraja, Bali 81116Dept. of Marine Culture, Ganesha Univ. of Education, Jl. Udayana No. 11 Singaraja, Bali 81116Res. and Dev.t Center for Marine and Fisheries Product Processing and Biotechnology, Jl. KS. Tubun Petamburan VI Jakarta, 10260Marine organisms, in particular nudibranchs (Mollusca: nudibranchia), are known as a rich source of chemically diverse secondary metabolites exhibiting potential as antimalarial, anti-inflammatory, antiviral and anticancer activity. We presented the chemical investigation of an extract of nudibranch Hypselodoris infucata collected from Bali, an unexplored water but rich in nudibranch diversity. The extract contained the known (–)-furodysinin (1), a furanosesquiterpene that for the first time isolated from this species. Metabolite 1 was purified by chromatography and the structure was characterised by comparison of 1H NMR data with that of the reported data. The absolute configuration was determined by comparing the optical rotation values with the known enantiomer. In vitro cytotoxic activity of compound 1 against HeLa cell line displayed an IC50 at 102.7µg/mL. We also report for the first time the development of a method to assay nudibranch extracts for their feeding deterrence activity against local shrimps Penaeus vannamei. The extract show food rejection with highly significant difference in respect to the control (P = 0.0061) at natural concentration of 3.0mg/mL.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1065nudibranchnatural productfeeding deterrenceHypselodoris |
| spellingShingle | I Wayan Mudianta Ni Wayan Martiningsih I Nyoman Dodik Prasetia Muhammad Nursid BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata Indonesian Journal of Pharmacy nudibranch natural product feeding deterrence Hypselodoris |
| title | BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata |
| title_full | BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata |
| title_fullStr | BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata |
| title_full_unstemmed | BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata |
| title_short | BIOACTIVE TERPENOID FROM THE BALINESE NUDIBRANCH Hypselodoris infucata |
| title_sort | bioactive terpenoid from the balinese nudibranch hypselodoris infucata |
| topic | nudibranch natural product feeding deterrence Hypselodoris |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1065 |
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