Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research

The potential role of mesenchymal stem cells (MSCs) in the treatment of metastatic cancers, including breast cancer, has been investigated for many years leading to encouraging results. The role of fat grafting and the related adipose-derived mesenchymal stem cells (AD-MSCs) has been detailed and de...

Mô tả đầy đủ

Chi tiết về thư mục
Tác giả chính: Pietro Gentile
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: MDPI AG 2022-05-01
Loạt:Biomedicines
Những chủ đề:
Truy cập trực tuyến:https://www.mdpi.com/2227-9059/10/5/1179
Miêu tả
Tóm tắt:The potential role of mesenchymal stem cells (MSCs) in the treatment of metastatic cancers, including breast cancer, has been investigated for many years leading to encouraging results. The role of fat grafting and the related adipose-derived mesenchymal stem cells (AD-MSCs) has been detailed and described for breast reconstruction purposes confirming the safety of AD-MSCs. MSCs have great potential for delivering anticancer agents, suicide genes, and oncolytic viruses to tumors. Currently, many studies have focused on the products of MSCs, including extracellular vesicles (EVs), as a cell-free therapy. This work aimed to review and discuss the current knowledge on MSCs and their EVs in breast cancer therapy.
số ISSN:2227-9059