Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research
The potential role of mesenchymal stem cells (MSCs) in the treatment of metastatic cancers, including breast cancer, has been investigated for many years leading to encouraging results. The role of fat grafting and the related adipose-derived mesenchymal stem cells (AD-MSCs) has been detailed and de...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/5/1179 |
| _version_ | 1827670132439121920 |
|---|---|
| author | Pietro Gentile |
| author_facet | Pietro Gentile |
| author_sort | Pietro Gentile |
| collection | DOAJ |
| description | The potential role of mesenchymal stem cells (MSCs) in the treatment of metastatic cancers, including breast cancer, has been investigated for many years leading to encouraging results. The role of fat grafting and the related adipose-derived mesenchymal stem cells (AD-MSCs) has been detailed and described for breast reconstruction purposes confirming the safety of AD-MSCs. MSCs have great potential for delivering anticancer agents, suicide genes, and oncolytic viruses to tumors. Currently, many studies have focused on the products of MSCs, including extracellular vesicles (EVs), as a cell-free therapy. This work aimed to review and discuss the current knowledge on MSCs and their EVs in breast cancer therapy. |
| first_indexed | 2024-03-10T03:16:47Z |
| format | Article |
| id | doaj.art-afea0cb078644658bf64accafb80feb3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:16:47Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-afea0cb078644658bf64accafb80feb32023-11-23T10:12:12ZengMDPI AGBiomedicines2227-90592022-05-01105117910.3390/biomedicines10051179Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical ResearchPietro Gentile0Department of Surgical Science, “Tor Vergata” University, 00133 Rome, ItalyThe potential role of mesenchymal stem cells (MSCs) in the treatment of metastatic cancers, including breast cancer, has been investigated for many years leading to encouraging results. The role of fat grafting and the related adipose-derived mesenchymal stem cells (AD-MSCs) has been detailed and described for breast reconstruction purposes confirming the safety of AD-MSCs. MSCs have great potential for delivering anticancer agents, suicide genes, and oncolytic viruses to tumors. Currently, many studies have focused on the products of MSCs, including extracellular vesicles (EVs), as a cell-free therapy. This work aimed to review and discuss the current knowledge on MSCs and their EVs in breast cancer therapy.https://www.mdpi.com/2227-9059/10/5/1179breast cancerbreast cancer and mesenchymal stem cellsbreast cancer therapy and stem cellsregenerative plastic surgeryplastic surgery |
| spellingShingle | Pietro Gentile Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research Biomedicines breast cancer breast cancer and mesenchymal stem cells breast cancer therapy and stem cells regenerative plastic surgery plastic surgery |
| title | Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research |
| title_full | Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research |
| title_fullStr | Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research |
| title_full_unstemmed | Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research |
| title_short | Breast Cancer Therapy: The Potential Role of Mesenchymal Stem Cells in Translational Biomedical Research |
| title_sort | breast cancer therapy the potential role of mesenchymal stem cells in translational biomedical research |
| topic | breast cancer breast cancer and mesenchymal stem cells breast cancer therapy and stem cells regenerative plastic surgery plastic surgery |
| url | https://www.mdpi.com/2227-9059/10/5/1179 |
| work_keys_str_mv | AT pietrogentile breastcancertherapythepotentialroleofmesenchymalstemcellsintranslationalbiomedicalresearch |