Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys
The interactions of anterior temporal structures, and especially the amygdala, with the prefrontal cortex are pivotal to learning, decision-making, and socio-emotional regulation. A clear anatomical description of the organization and dissociation of fiber bundles linking anterior temporal cortex/am...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/47175 |
| _version_ | 1828169034761240576 |
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| author | Davide Folloni Jerome Sallet Alexandre A Khrapitchev Nicola Sibson Lennart Verhagen Rogier B Mars |
| author_facet | Davide Folloni Jerome Sallet Alexandre A Khrapitchev Nicola Sibson Lennart Verhagen Rogier B Mars |
| author_sort | Davide Folloni |
| collection | DOAJ |
| description | The interactions of anterior temporal structures, and especially the amygdala, with the prefrontal cortex are pivotal to learning, decision-making, and socio-emotional regulation. A clear anatomical description of the organization and dissociation of fiber bundles linking anterior temporal cortex/amygdala and prefrontal cortex in humans is still lacking. Using diffusion imaging techniques, we reconstructed fiber bundles between these anatomical regions in human and macaque brains. First, by studying macaques, we assessed which aspects of connectivity known from tracer studies could be identified with diffusion imaging. Second, by comparing diffusion imaging results in humans and macaques, we estimated the patterns of fibers coursing between human amygdala and prefrontal cortex and compared them with those in the monkey. In posterior prefrontal cortex, we observed a prominent and well-preserved bifurcation of bundles into primarily two fiber systems—an amygdalofugal path and an uncinate path—in both species. This dissociation fades away in more rostral prefrontal regions. |
| first_indexed | 2024-04-12T02:44:34Z |
| format | Article |
| id | doaj.art-afeb8a4e65f34f2c8e58e63594a9b6be |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:44:34Z |
| publishDate | 2019-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-afeb8a4e65f34f2c8e58e63594a9b6be2022-12-22T03:51:13ZengeLife Sciences Publications LtdeLife2050-084X2019-11-01810.7554/eLife.47175Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeysDavide Folloni0https://orcid.org/0000-0003-1653-5969Jerome Sallet1https://orcid.org/0000-0002-7878-0209Alexandre A Khrapitchev2https://orcid.org/0000-0002-7616-6635Nicola Sibson3Lennart Verhagen4https://orcid.org/0000-0003-3207-7929Rogier B Mars5https://orcid.org/0000-0001-6302-8631Wellcome Centre for Integrative Neuroimaging (WIN),Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB),Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United KingdomWellcome Centre for Integrative Neuroimaging (WIN),Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB),Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United KingdomDepartment of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United KingdomDepartment of Oncology, Cancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United KingdomWellcome Centre for Integrative Neuroimaging (WIN),Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB),Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, NetherlandsWellcome Centre for Integrative Neuroimaging (WIN), Centre for Functional MRI of the Brain (FMRIB),Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, NetherlandsThe interactions of anterior temporal structures, and especially the amygdala, with the prefrontal cortex are pivotal to learning, decision-making, and socio-emotional regulation. A clear anatomical description of the organization and dissociation of fiber bundles linking anterior temporal cortex/amygdala and prefrontal cortex in humans is still lacking. Using diffusion imaging techniques, we reconstructed fiber bundles between these anatomical regions in human and macaque brains. First, by studying macaques, we assessed which aspects of connectivity known from tracer studies could be identified with diffusion imaging. Second, by comparing diffusion imaging results in humans and macaques, we estimated the patterns of fibers coursing between human amygdala and prefrontal cortex and compared them with those in the monkey. In posterior prefrontal cortex, we observed a prominent and well-preserved bifurcation of bundles into primarily two fiber systems—an amygdalofugal path and an uncinate path—in both species. This dissociation fades away in more rostral prefrontal regions.https://elifesciences.org/articles/47175connectivitydiffusion MRIamygdalaprefrontal cortexdecision-makingemotional behaviour |
| spellingShingle | Davide Folloni Jerome Sallet Alexandre A Khrapitchev Nicola Sibson Lennart Verhagen Rogier B Mars Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys eLife connectivity diffusion MRI amygdala prefrontal cortex decision-making emotional behaviour |
| title | Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys |
| title_full | Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys |
| title_fullStr | Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys |
| title_full_unstemmed | Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys |
| title_short | Dichotomous organization of amygdala/temporal-prefrontal bundles in both humans and monkeys |
| title_sort | dichotomous organization of amygdala temporal prefrontal bundles in both humans and monkeys |
| topic | connectivity diffusion MRI amygdala prefrontal cortex decision-making emotional behaviour |
| url | https://elifesciences.org/articles/47175 |
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