An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma
Whether albumin and bilirubin levels, platelet counts, ALBI, and ALPlat scores could be useful for the assessment of permanent liver functional deterioration after repeat liver resection was examined, and the deterioration after laparoscopic procedure was evaluated. For 657 patients with liver resec...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/11/2598 |
| _version_ | 1797494000812294144 |
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| author | Zenichi Morise Luca Aldrighetti Giulio Belli Francesca Ratti Tan To Cheung Chung Mau Lo Shogo Tanaka Shoji Kubo Yukiyasu Okamura Katsuhiko Uesaka Kazuteru Monden Hiroshi Sadamori Kazuki Hashida Kazuyuki Kawamoto Naoto Gotohda KuoHsin Chen Akishige Kanazawa Yutaka Takeda Yoshiaki Ohmura Masaki Ueno Toshiro Ogura Kyung Suk Suh Yutaro Kato Atsushi Sugioka Andrea Belli Hiroyuki Nitta Masafumi Yasunaga Daniel Cherqui Nasser Abdul Halim Alexis Laurent Hironori Kaneko Yuichiro Otsuka Ki Hun Kim Hwui-Dong Cho Charles Chung-Wei Lin Yusuke Ome Yasuji Seyama Roberto I. Troisi Giammauro Berardi Fernando Rotellar Gregory C. Wilson David A. Geller Olivier Soubrane Tomoaki Yoh Takashi Kaizu Yusuke Kumamoto Ho-Seong Han Ela Ekmekcigil Ibrahim Dagher David Fuks Brice Gayet Joseph F. Buell Ruben Ciria Javier Briceno Nicholas O’Rourke Joel Lewin Bjorn Edwin Masahiro Shinoda Yuta Abe Mohammed Abu Hilal Mohammad Alzoubi Minoru Tanabe Go Wakabayashi |
| author_facet | Zenichi Morise Luca Aldrighetti Giulio Belli Francesca Ratti Tan To Cheung Chung Mau Lo Shogo Tanaka Shoji Kubo Yukiyasu Okamura Katsuhiko Uesaka Kazuteru Monden Hiroshi Sadamori Kazuki Hashida Kazuyuki Kawamoto Naoto Gotohda KuoHsin Chen Akishige Kanazawa Yutaka Takeda Yoshiaki Ohmura Masaki Ueno Toshiro Ogura Kyung Suk Suh Yutaro Kato Atsushi Sugioka Andrea Belli Hiroyuki Nitta Masafumi Yasunaga Daniel Cherqui Nasser Abdul Halim Alexis Laurent Hironori Kaneko Yuichiro Otsuka Ki Hun Kim Hwui-Dong Cho Charles Chung-Wei Lin Yusuke Ome Yasuji Seyama Roberto I. Troisi Giammauro Berardi Fernando Rotellar Gregory C. Wilson David A. Geller Olivier Soubrane Tomoaki Yoh Takashi Kaizu Yusuke Kumamoto Ho-Seong Han Ela Ekmekcigil Ibrahim Dagher David Fuks Brice Gayet Joseph F. Buell Ruben Ciria Javier Briceno Nicholas O’Rourke Joel Lewin Bjorn Edwin Masahiro Shinoda Yuta Abe Mohammed Abu Hilal Mohammad Alzoubi Minoru Tanabe Go Wakabayashi |
| author_sort | Zenichi Morise |
| collection | DOAJ |
| description | Whether albumin and bilirubin levels, platelet counts, ALBI, and ALPlat scores could be useful for the assessment of permanent liver functional deterioration after repeat liver resection was examined, and the deterioration after laparoscopic procedure was evaluated. For 657 patients with liver resection of segment or less in whom results of plasma albumin and bilirubin levels and platelet counts before and 3 months after surgery could be retrieved, liver functional indicators were compared before and after surgery. There were 268 patients who underwent open repeat after previous open liver resection, and 224 patients who underwent laparoscopic repeat after laparoscopic liver resection. The background factors, liver functional indicators before and after surgery and their changes were compared between both groups. Plasma levels of albumin (<i>p </i>= 0.006) and total bilirubin (<i>p </i>= 0.01) were decreased, and ALBI score (<i>p </i>= 0.001) indicated worse liver function after surgery. Laparoscopic group had poorer preoperative performance status and liver function. Changes of liver functional values before and after surgery and overall survivals were similar between laparoscopic and open groups. Plasma levels of albumin and bilirubin and ALBI score could be the indicators for permanent liver functional deterioration after liver resection. Laparoscopic group with poorer conditions showed the similar deterioration of liver function and overall survivals to open group. |
| first_indexed | 2024-03-10T01:28:01Z |
| format | Article |
| id | doaj.art-aff0445387a9461fb52188911c8f0188 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:28:01Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-aff0445387a9461fb52188911c8f01882023-11-23T13:47:57ZengMDPI AGCancers2072-66942022-05-011411259810.3390/cancers14112598An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular CarcinomaZenichi Morise0Luca Aldrighetti1Giulio Belli2Francesca Ratti3Tan To Cheung4Chung Mau Lo5Shogo Tanaka6Shoji Kubo7Yukiyasu Okamura8Katsuhiko Uesaka9Kazuteru Monden10Hiroshi Sadamori11Kazuki Hashida12Kazuyuki Kawamoto13Naoto Gotohda14KuoHsin Chen15Akishige Kanazawa16Yutaka Takeda17Yoshiaki Ohmura18Masaki Ueno19Toshiro Ogura20Kyung Suk Suh21Yutaro Kato22Atsushi Sugioka23Andrea Belli24Hiroyuki Nitta25Masafumi Yasunaga26Daniel Cherqui27Nasser Abdul Halim28Alexis Laurent29Hironori Kaneko30Yuichiro Otsuka31Ki Hun Kim32Hwui-Dong Cho33Charles Chung-Wei Lin34Yusuke Ome35Yasuji Seyama36Roberto I. Troisi37Giammauro Berardi38Fernando Rotellar39Gregory C. Wilson40David A. Geller41Olivier Soubrane42Tomoaki Yoh43Takashi Kaizu44Yusuke Kumamoto45Ho-Seong Han46Ela Ekmekcigil47Ibrahim Dagher48David Fuks49Brice Gayet50Joseph F. Buell51Ruben Ciria52Javier Briceno53Nicholas O’Rourke54Joel Lewin55Bjorn Edwin56Masahiro Shinoda57Yuta Abe58Mohammed Abu Hilal59Mohammad Alzoubi60Minoru Tanabe61Go Wakabayashi62Department of General Surgery, Fujita Health University School of Medicine Okazaki Medical Center, Okazaki 444-0827, JapanHepatobiliary Division in Department of Surgery, San Raffaele Hospital, 20132 Milano, ItalyDepartment of General and HPB Surgery, Loreto Nuovo Hospital, 80127 Naples, ItalyHepatobiliary Division in Department of Surgery, San Raffaele Hospital, 20132 Milano, ItalyDivision of HBP and Liver Transplant, University of Hong Kong Queen Mary Hospital, Hong Kong, ChinaDivision of HBP and Liver Transplant, University of Hong Kong Queen Mary Hospital, Hong Kong, ChinaDepartment of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8586, JapanDepartment of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, Osaka 545-8586, JapanDivision of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, Sunto, Shizuoka 411-8777, JapanDivision of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, Sunto, Shizuoka 411-8777, JapanDepartments of Surgery, Fukuyama City Hospital, Fukuyama 721-8511, JapanDepartments of Surgery, Fukuyama City Hospital, Fukuyama 721-8511, JapanDepartment of Surgery, Kurashiki Central Hospital, Kurashiki 710-8602, JapanDepartment of Surgery, Kurashiki Central Hospital, Kurashiki 710-8602, JapanDivision of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa 277-8577, JapanDivision of General Surgery, Department of Surgery, Far-Eastern Memorial Hospital, New Taipei City 220, TaiwanDepartment of Hepato-Biliary-Pancreatic Surgery, Osaka City General Hospital, Osaka 534-0021, JapanDepartment of Surgery, Kansai Rosai Hospital, Amagasaki 660-8511, JapanDepartment of Surgery, Kansai Rosai Hospital, Amagasaki 660-8511, JapanSecond Department of Surgery, Wakayama Medical University, Wakayama 641-8509, JapanDepartment of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Hepatobiliary and Pancreatic Surgery, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Gastrointestinal Surgery, Fujita Health University School of Medicine, Toyoake 470-1192, JapanDepartment of Gastrointestinal Surgery, Fujita Health University School of Medicine, Toyoake 470-1192, JapanDepartment of Abdominal Surgical Oncology, Fondazione G. Pascale-IRCCS, National Cancer Institute of Naples, 80131 Napoli, ItalyDepartment of Surgery, Iwate Medical University, Morioka 028-3695, JapanDepartment of Surgery, Kurume University School of Medicine, Kurume 830-0011, JapanPaul Brousse Hospital, 94800 Villejuif, FrancePaul Brousse Hospital, 94800 Villejuif, FranceParis-Sud University, 91190 Gif-sur-Yvette, FranceDivision of General and Gastroenterological Surgery, Department of Surgery, Toho University Faculty of Medicine, Tokyo 143-8540, JapanDivision of General and Gastroenterological Surgery, Department of Surgery, Toho University Faculty of Medicine, Tokyo 143-8540, JapanDivision of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Ulsan University and Asan Medical Center, Seoul 05505, KoreaDivision of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Ulsan University and Asan Medical Center, Seoul 05505, KoreaDepartment of Surgery and Surgical Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 112, TaiwanDepartment of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, JapanDepartment of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, JapanDepartment of Clinical Medicine and Surgery, University of Naples Federico II, 80138 Napoli, ItalyGeneral Hepato-Biliary and Liver Transplantation Surgery, Ghent University Hospital Medical School, 9000 Gent, BelgiumHepato-Bilio-Pancreatic Unit of Clinica Universitaria de Navarra, 31008 Pamplona, SpainDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of HPB Surgery and Liver Transplant, Beaujon Hospital, Clichy 92110, FranceDepartment of HPB Surgery and Liver Transplant, Beaujon Hospital, Clichy 92110, FranceDepartment of Surgery, Kitasato University School of Medicine, Sagamihara 252-0374, JapanDepartment of Surgery, Kitasato University School of Medicine, Sagamihara 252-0374, JapanSeoul National University College of Medicine, Bundang Hospital, Seongnam-si 13620, KoreaSeoul National University College of Medicine, Bundang Hospital, Seongnam-si 13620, KoreaAntoine Beclere Hospital, 92140 Clamart, FranceDepartment of Digestive Diseases, Institute Mutualiste Montsouris, University of Paris Descartes, 75014 Paris, FranceDepartment of Digestive Diseases, Institute Mutualiste Montsouris, University of Paris Descartes, 75014 Paris, FranceTulane Transplant Abdominal Institute, Tulane University, New Orleans, LA 70112, USAUnit of Hepatobiliary Surgery and Liver Transplantation, University Hospital Reina Sofia, 30003 Murcia, SpainUnit of Hepatobiliary Surgery and Liver Transplantation, University Hospital Reina Sofia, 30003 Murcia, SpainDepartment of General Surgery and HPB Surgery, Royal Brisbane Hospital, The University of Queensland, St Lucia, QLD 4072, AustraliaDepartment of General Surgery and HPB Surgery, Royal Brisbane Hospital, The University of Queensland, St Lucia, QLD 4072, AustraliaDepartment of Hepatopancreatobiliary Surgery, Oslo University Hospital-Rikshospitalet, 0372 Oslo, NorwayDepartment of Surgery, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Surgery, Keio University School of Medicine, Tokyo 160-8582, JapanIstituto Ospedaliero—Fondazione Poliambulanza, 25124 Brescia, BS, ItalyUniversity Hospital Southampton, Hampshire SO16 6YD, UKDepartment of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, JapanDepartment of Surgery, Ageo Central General Hospital, Ageo 362-8588, JapanWhether albumin and bilirubin levels, platelet counts, ALBI, and ALPlat scores could be useful for the assessment of permanent liver functional deterioration after repeat liver resection was examined, and the deterioration after laparoscopic procedure was evaluated. For 657 patients with liver resection of segment or less in whom results of plasma albumin and bilirubin levels and platelet counts before and 3 months after surgery could be retrieved, liver functional indicators were compared before and after surgery. There were 268 patients who underwent open repeat after previous open liver resection, and 224 patients who underwent laparoscopic repeat after laparoscopic liver resection. The background factors, liver functional indicators before and after surgery and their changes were compared between both groups. Plasma levels of albumin (<i>p </i>= 0.006) and total bilirubin (<i>p </i>= 0.01) were decreased, and ALBI score (<i>p </i>= 0.001) indicated worse liver function after surgery. Laparoscopic group had poorer preoperative performance status and liver function. Changes of liver functional values before and after surgery and overall survivals were similar between laparoscopic and open groups. Plasma levels of albumin and bilirubin and ALBI score could be the indicators for permanent liver functional deterioration after liver resection. Laparoscopic group with poorer conditions showed the similar deterioration of liver function and overall survivals to open group.https://www.mdpi.com/2072-6694/14/11/2598laparoscopic liver resectionrepeat liver resectionliver functionliver functional deteriorationoverall survival |
| spellingShingle | Zenichi Morise Luca Aldrighetti Giulio Belli Francesca Ratti Tan To Cheung Chung Mau Lo Shogo Tanaka Shoji Kubo Yukiyasu Okamura Katsuhiko Uesaka Kazuteru Monden Hiroshi Sadamori Kazuki Hashida Kazuyuki Kawamoto Naoto Gotohda KuoHsin Chen Akishige Kanazawa Yutaka Takeda Yoshiaki Ohmura Masaki Ueno Toshiro Ogura Kyung Suk Suh Yutaro Kato Atsushi Sugioka Andrea Belli Hiroyuki Nitta Masafumi Yasunaga Daniel Cherqui Nasser Abdul Halim Alexis Laurent Hironori Kaneko Yuichiro Otsuka Ki Hun Kim Hwui-Dong Cho Charles Chung-Wei Lin Yusuke Ome Yasuji Seyama Roberto I. Troisi Giammauro Berardi Fernando Rotellar Gregory C. Wilson David A. Geller Olivier Soubrane Tomoaki Yoh Takashi Kaizu Yusuke Kumamoto Ho-Seong Han Ela Ekmekcigil Ibrahim Dagher David Fuks Brice Gayet Joseph F. Buell Ruben Ciria Javier Briceno Nicholas O’Rourke Joel Lewin Bjorn Edwin Masahiro Shinoda Yuta Abe Mohammed Abu Hilal Mohammad Alzoubi Minoru Tanabe Go Wakabayashi An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma Cancers laparoscopic liver resection repeat liver resection liver function liver functional deterioration overall survival |
| title | An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma |
| title_full | An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma |
| title_fullStr | An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma |
| title_full_unstemmed | An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma |
| title_short | An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma |
| title_sort | international retrospective observational study of liver functional deterioration after repeat liver resection for patients with hepatocellular carcinoma |
| topic | laparoscopic liver resection repeat liver resection liver function liver functional deterioration overall survival |
| url | https://www.mdpi.com/2072-6694/14/11/2598 |
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internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT rubenciria internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT javierbriceno internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT nicholasorourke internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT joellewin internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT bjornedwin internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT masahiroshinoda internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT yutaabe internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT mohammedabuhilal internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT mohammadalzoubi internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT minorutanabe internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma AT gowakabayashi internationalretrospectiveobservationalstudyofliverfunctionaldeteriorationafterrepeatliverresectionforpatientswithhepatocellularcarcinoma |