The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

<p>Abstract</p> <p>Background</p> <p>Activated microglia are a feature of the host response to neurodegeneration in Parkinson's disease (PD) and are thought to contribute to disease progression. Recent evidence suggests that extracellular α-synuclein (eSNCA) may pl...

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Bibliographic Details
Main Authors: Couch Yvonne, Alvarez-Erviti Lydia, Sibson Nicola R, Wood Matthew JA, Anthony Daniel C
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Journal of Neuroinflammation
Subjects:
brain
inflammation
α-synuclein
SNCA
cytokine
Parkinson's
chemokine
Online Access:http://www.jneuroinflammation.com/content/8/1/166

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