ApoA-I Mimetic Peptide Reduces Vascular and White Matter Damage After Stroke in Type-2 Diabetic Mice

ApoA-I Mimetic Peptide Reduces Vascular and White Matter Damage After Stroke in Type-2 Diabetic Mice

Diabetes leads to an elevated risk of stroke and worse functional outcome compared to the general population. We investigate whether L-4F, an economical ApoA-I mimetic peptide, reduces neurovascular and white-matter damage in db/db type-2 diabetic (T2DM) stroke mice. L-4F (16 mg/kg, subcutaneously a...

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Bibliographic Details
Main Authors: Xiaohui Wang, Rongwen Li, Alex Zacharek, Julie Landschoot-Ward, Michael Chopp, Jieli Chen, Xu Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Neuroscience
Subjects:
diabetes
stroke
blood–brain barrier (BBB)
white matter (WM)
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01127/full

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