SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease
Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/9/880 |
| _version_ | 1797581049473007616 |
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| author | Feng Gao Fang Li Jianhao Wang Hang Yu Xiang Li Hongyu Chen Jiabei Wang Dongdong Qin Yiyi Li Songyan Liu Xi Zhang Zhi-Hao Wang |
| author_facet | Feng Gao Fang Li Jianhao Wang Hang Yu Xiang Li Hongyu Chen Jiabei Wang Dongdong Qin Yiyi Li Songyan Liu Xi Zhang Zhi-Hao Wang |
| author_sort | Feng Gao |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined. |
| first_indexed | 2024-03-10T22:59:37Z |
| format | Article |
| id | doaj.art-aff1d29852254cb6a442f92d7238a02e |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-10T22:59:37Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-aff1d29852254cb6a442f92d7238a02e2023-11-19T09:47:36ZengMDPI AGBiosensors2079-63742023-09-0113988010.3390/bios13090880SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s DiseaseFeng Gao0Fang Li1Jianhao Wang2Hang Yu3Xiang Li4Hongyu Chen5Jiabei Wang6Dongdong Qin7Yiyi Li8Songyan Liu9Xi Zhang10Zhi-Hao Wang11Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaAlzheimer’s disease (AD) is a leading cause of dementia, impacting millions worldwide. However, its complex neuropathologic features and heterogeneous pathophysiology present significant challenges for diagnosis and treatment. To address the urgent need for early AD diagnosis, this review focuses on surface-enhanced Raman scattering (SERS)-based biosensors, leveraging the excellent optical properties of nanomaterials to enhance detection performance. These highly sensitive and noninvasive biosensors offer opportunities for biomarker-driven clinical diagnostics and precision medicine. The review highlights various types of SERS-based biosensors targeting AD biomarkers, discussing their potential applications and contributions to AD diagnosis. Specific details about nanomaterials and targeted AD biomarkers are provided. Furthermore, the future research directions and challenges for improving AD marker detection using SERS sensors are outlined.https://www.mdpi.com/2079-6374/13/9/880Alzheimer’s diseaseSERSnanoparticlesfluid biomarkersdisease diagnosisbiosensor |
| spellingShingle | Feng Gao Fang Li Jianhao Wang Hang Yu Xiang Li Hongyu Chen Jiabei Wang Dongdong Qin Yiyi Li Songyan Liu Xi Zhang Zhi-Hao Wang SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease Biosensors Alzheimer’s disease SERS nanoparticles fluid biomarkers disease diagnosis biosensor |
| title | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
| title_full | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
| title_fullStr | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
| title_full_unstemmed | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
| title_short | SERS-Based Optical Nanobiosensors for the Detection of Alzheimer’s Disease |
| title_sort | sers based optical nanobiosensors for the detection of alzheimer s disease |
| topic | Alzheimer’s disease SERS nanoparticles fluid biomarkers disease diagnosis biosensor |
| url | https://www.mdpi.com/2079-6374/13/9/880 |
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