Mutant HTT does not affect glial development but impairs myelination in the early disease stage

Mutant HTT does not affect glial development but impairs myelination in the early disease stage

IntroductionHuntington’s disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT) and is characterized by late-onset neurodegeneration that primarily affects the striatum. Several studies have shown that mutant HTT can also affect neuronal development, contributing to the late-ons...

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Bibliographic Details
Main Authors: Sitong Yang, Jingjing Ma, Han Zhang, Laiqiang Chen, Yuxuan Li, Mingtian Pan, Hongcheng Zhu, Jun Liang, Dajian He, Shihua Li, Xiao-Jiang Li, Xiangyu Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Neuroscience
Subjects:
Huntington’s disease
glia
development
demyelination
oligodendrocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1238306/full

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